U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 23:06:22 GMT 2025
Edited
by admin
on Tue Apr 01 23:06:22 GMT 2025
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
B2KH16FA7H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Anvatabart Opadotin
INN   USAN  
Official Name English
ARX-788
Preferred Name English
ARX 788 [WHO-DD]
Common Name English
gamma1 heavy chain humanized (1-449) [VH humanized (Homo sapiens IGHV3-66*01 (81.6%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*01, G1m17,1 (CH1 A1.4>F (pAF) (121), K120 (217) (121- 218), hinge 1-15 (219
Common Name English
ARX788
Code English
ARX-788 (ANTI-HER2 MAB PAF- MMAF TOXIN OXIME CONJUGATE)
Common Name English
ANVATABART OPAFIDOTIN [USAN]
Common Name English
anvatabart opadotin [INN]
Common Name English
Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine-protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody; conjugated at two engineered sites via a stable
Common Name English
Immunoglobulin G1 [121-(4-acetylphenylalanine),de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal Amab788 ?1-chain), disulfide with human-Mus musculus monoclonal Amab788 ?-chain, dimer, 121,121?-dioxime with
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 794820
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
Code System Code Type Description
FDA UNII
B2KH16FA7H
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
USAN
KL-238
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
INN
12272
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
SMS_ID
300000034918
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
NCI_THESAURUS
C123917
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
CAS
2636710-07-9
Created by admin on Tue Apr 01 23:06:22 GMT 2025 , Edited by admin on Tue Apr 01 23:06:22 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_147 2_203
2_223 4_214
2_264 2_324
1_147 1_203
2_370 2_428
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_223 3_214
1_229 2_229
1_232 2_232
1_264 1_324
1_370 1_428
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_300
N 2_300
Related Record Type Details
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
TARGET->CONJUGATED TOXIN
Structure of Opadotin
TOXIN -> CONJUGATE
Related Record Type Details
Anvatabart Opadotin
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_121] [2_121] SITE_SPECIFIC UNSPECIFIED SUBSTANCE
94f851be
(not in database)
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966