C-X-C CHEMOKINE RECEPTOR TYPE 4

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:15:47 GMT 2025` Edited by `admin` on `Tue Apr 01 19:15:47 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type	CYTOKINE RECEPTOR
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	B5GGG91KI4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

C-X-C CHEMOKINE RECEPTOR TYPE 4

Common Name

English

CD_ANTIGEN: CD184

Preferred Name

English

LIPOPOLYSACCHARIDE-ASSOCIATED PROTEIN 3

Common Name

English

CXCR4

Common Name

English

FB22

Common Name

English

LPS-ASSOCIATED PROTEIN 3

Common Name

English

SDF-1 RECEPTOR

Common Name

English

FUSIN

Common Name

English

HM89

Common Name

English

CXC-R4

Common Name

English

STROMAL CELL-DERIVED FACTOR 1 RECEPTOR

Common Name

English

LCR1

Common Name

English

NPYRL

Common Name

English

CXCR-4

Common Name

English

LEUKOCYTE-DERIVED SEVEN TRANSMEMBRANE DOMAIN RECEPTOR

Common Name

English

LESTR

Common Name

English

Code System Code Type Description

PHAROS

P61073

Created by admin on Tue Apr 01 19:15:47 GMT 2025 , Edited by admin on Tue Apr 01 19:15:47 GMT 2025

PRIMARY

UNIPROT

P61073

Created by admin on Tue Apr 01 19:15:47 GMT 2025 , Edited by admin on Tue Apr 01 19:15:47 GMT 2025

PRIMARY

FDA UNII

B5GGG91KI4

Created by admin on Tue Apr 01 19:15:47 GMT 2025 , Edited by admin on Tue Apr 01 19:15:47 GMT 2025

PRIMARY

WIKIPEDIA

CXCR4

Created by admin on Tue Apr 01 19:15:47 GMT 2025 , Edited by admin on Tue Apr 01 19:15:47 GMT 2025

PRIMARY

From	To
1_28	1_274
1_109	1_186

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_11
N	1_176
O	1_18

Related Record Type Details


					S915P5499N

PLERIXAFOR

INHIBITOR -> TARGET


					7TS9C20ZWA

PF-06747143

INHIBITOR -> TARGET

Comments:

Binds to CXCR4, thereby preventing the binding of stromal cell-derived factor-1 (SDF-1 or CXCL12) to CXCR4 and inhibiting CXCR4 activation. This results in decreased proliferation and migration of CXCR4-expressing tumor cells. In addition, PF-06747143 promotes cell death through the induction of both complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC).


					FBZ2DKU32N

EMILIMOGENE SIGULACTIBAC

AGONIST -> TARGET

Comments:

Dimeric form acts as a partial agonist of CXCR4.

Amount:


					DA9G065962

MOTIXAFORTIDE

INHIBITOR -> TARGET


					Y92N1ZLI87

GALLIUM (68GA) BOCLATIXAFORTIDE

RADIOLIGAND->TARGET

Amount:


					TWM9C4NTQ6

AD-114

INHIBITOR -> TARGET

Amount:


					NF0BX95A31

CTCE-9908

INHIBITOR -> TARGET


					9T04Q997SD

LY-2624587

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					UA96NQU2PH

AD-214

INHIBITOR -> TARGET

Amount:


					IMD9Z48ZTT

AMD-8664

INHIBITOR -> TARGET

Amount:


					0G9LGB5O2W

Mavorixafor

INHIBITOR -> TARGET

Amount:


					PRC974M49B

BALIXAFORTIDE

INHIBITOR -> TARGET


					2G17Y0Q20G

BURIXAFOR

INHIBITOR -> TARGET

Amount:


					TOZ93UY3AX

BOCLATIXAFORTIDE

LIGAND->TARGET

Amount:


					2BTG5MX2Q2

USL-311

INHIBITOR -> TARGET


					7KNP87L4X4

ULOCUPLUMAB

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_7] [1_12] [1_21]	SITE_SPECIFIC			TYROSINE O-SULFATE	29166358BF
AMINO_ACID_SUBSTITUTION	[1_330] [1_339]	SITE_SPECIFIC			DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL
Molecular Formula	CHEMICAL