NIDUFEXOR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H22ClN3O4
Molecular Weight	487.934
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1N=C(C(=O)N(CC2=CC=CC=C2)CC3=CC=C(C=C3)C(O)=O)C4=C1C5=CC(Cl)=CC=C5OC4

InChI

InChIKey=JYTIXGYXBIBOMN-UHFFFAOYSA-N

InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34)

HIDE SMILES / InChI

Molecular Formula	C27H22ClN3O4
Molecular Weight	487.934
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

C_max

Value	Dose	Co-administered	Analyte	Population
1090 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT03804879	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:		NIDUFEXOR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: food status: UNKNOWN
1300 ng/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT03804879	50 mg 1 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered:		NIDUFEXOR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
3710 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT03804879	50 mg single, oral dose: 50 mg route of administration: Oral experiment type: SINGLE co-administered:		NIDUFEXOR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: food status: UNKNOWN
4850 ng × h/mL CLINICAL TRIAL clinicaltrials.gov/ct2/show/results/NCT03804879	50 mg 1 times / day multiple, oral dose: 50 mg route of administration: Oral experiment type: MULTIPLE co-administered:		NIDUFEXOR plasma	Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Substance Class	Chemical Created by `admin` on `Tue Apr 01 16:23:35 GMT 2025` Edited by `admin` on `Tue Apr 01 16:23:35 GMT 2025`
Record UNII	CJ1PL0TE6J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NIDUFEXOR

Official Name

English

LMB763

Preferred Name

English

BENZOIC ACID, 4-((((8-CHLORO-1,4-DIHYDRO-1-METHYL(1)BENZOPYRANO(4,3-C)PYRAZOL-3-YL)CARBONYL)(PHENYLMETHYL)AMINO)METHYL)-

Systematic Name

English

Nidufexor [WHO-DD]

Common Name

English

nidufexor [INN]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C174657