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Details

Stereochemistry ACHIRAL
Molecular Formula C19H16N8O
Molecular Weight 372.3833
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PF-04217903

SMILES

OCCN1C=C(C=N1)C2=CN=C3N=NN(CC4=CC=C5N=CC=CC5=C4)C3=N2

InChI

InChIKey=PDMUGYOXRHVNMO-UHFFFAOYSA-N
InChI=1S/C19H16N8O/c28-7-6-26-12-15(9-22-26)17-10-21-18-19(23-17)27(25-24-18)11-13-3-4-16-14(8-13)2-1-5-20-16/h1-5,8-10,12,28H,6-7,11H2

HIDE SMILES / InChI
Molecular Formula C19H16N8O
Molecular Weight 372.3833
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:37:56 UTC 2023
Edited
by admin
on Sat Dec 16 01:37:56 UTC 2023
Record UNII
CYJ9ATV1IJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PF-04217903
Common Name English
PF-4217903
Code English
2-(4-(1-(QUINOLIN-6-YLMETHYL)-1H-(1,2,3)TRIAZOLO(4,5-B)PYRAZIN-6-YL)-1H-PYRAZOL-1-YL)ETHANOL
Systematic Name English
1H-PYRAZOLE-1-ETHANOL, 4-(1-(6-QUINOLINYLMETHYL)-1H-1,2,3-TRIAZOLO(4,5-B)PYRAZIN-6-YL)
Systematic Name English
MET TYROSINE KINASE INHIBITOR PF-04217903
Code English
Classification Tree Code System Code
NCI_THESAURUS C143099
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
Code System Code Type Description
CAS
956905-27-4
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
PUBCHEM
17754438
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
DRUG BANK
DB12848
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
FDA UNII
CYJ9ATV1IJ
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
EPA CompTox
DTXSID401026097
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
SMS_ID
300000041325
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
ChEMBL
CHEMBL2001019
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
NCI_THESAURUS
C78483
Created by admin on Sat Dec 16 01:37:56 UTC 2023 , Edited by admin on Sat Dec 16 01:37:56 UTC 2023
PRIMARY
Related Record Type Details
Structure of PF-04217903 MESYLATE
SALT/SOLVATE -> PARENT
Structure of PF-04217903 MONOPHOSPHATE
SALT/SOLVATE -> PARENT
CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A
OFF TARGET->WEAK INHIBITOR
IC50
Structure of PF-04217903 HYDROCHLORIDE
SALT/SOLVATE -> PARENT
CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B
OFF TARGET->WEAK INHIBITOR
No cardiac toxicity seen in clinical trials
IC50
PHOSPHODIESTERASE 5A, HUMAN
OFF TARGET->WEAK INHIBITOR
IC50
HEPATOCYTE GROWTH FACTOR RECEPTOR
TARGET -> INHIBITOR
Ki
Related Record Type Details
Structure of PF-04217903
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