U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 01:22:07 GMT 2025
Edited
by admin
on Wed Apr 02 01:22:07 GMT 2025
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
D9SCP0G3HF
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
G-PROTEIN COUPLED RECEPTOR 97
Preferred Name English
HISTAMINE H3 RECEPTOR
Common Name English
GPCR97
Common Name English
H3R
Common Name English
HH3R
Common Name English
Code System Code Type Description
WIKIPEDIA
Histamine H3 receptor
Created by admin on Wed Apr 02 01:22:07 GMT 2025 , Edited by admin on Wed Apr 02 01:22:07 GMT 2025
PRIMARY
PHAROS
Q9Y5N1
Created by admin on Wed Apr 02 01:22:07 GMT 2025 , Edited by admin on Wed Apr 02 01:22:07 GMT 2025
PRIMARY
UNIPROT
Q9Y5N1
Created by admin on Wed Apr 02 01:22:07 GMT 2025 , Edited by admin on Wed Apr 02 01:22:07 GMT 2025
PRIMARY
FDA UNII
D9SCP0G3HF
Created by admin on Wed Apr 02 01:22:07 GMT 2025 , Edited by admin on Wed Apr 02 01:22:07 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_11
Related Record Type Details
Structure of 2-(Cyclohexylmethyl)-1,2,3,4-tetrahydro-N-[2-[(2S)-1-methyl-2-pyrrolidinyl]ethyl]-7-isoquinolinesulfonamide
INHIBITOR -> TARGET
Structure of MK-8278 C-11
INVERSE AGONIST->TARGET
Structure of IRDABISANT
INHIBITOR -> TARGET
Structure of GSK-189254
INHIBITOR -> TARGET
INHIBITOR
Ki
Structure of BAVISANT
INHIBITOR -> TARGET
Structure of S-38093
INVERSE AGONIST->TARGET
Ki
Structure of CIPROXIFAN
INHIBITOR -> TARGET
Structure of ENERISANT
INHIBITOR -> TARGET
Structure of CIPRALISANT
LIGAND->TARGET
Structure of GSK-1004723
INHIBITOR -> TARGET
Long acting slowly dissociates.
Ki
Structure of VUF-5681
INHIBITOR -> TARGET
Could have partial agonist activity. 3H-cAMP accumulation
IC50
Structure of MITAPIVAT
INHIBITOR->OFF-TARGET
BINDING ASSAY
IC50
Structure of LML-134
INVERSE AGONIST->TARGET
cAMP functional assay
Ki
Structure of PF-03654746
INHIBITOR -> TARGET
Structure of PITOLISANT
INVERSE AGONIST->TARGET
Structure of SAMELISANT
INVERSE AGONIST->TARGET
Structure of MITAPIVAT
INVERSE AGONIST->TARGET
IC50
Structure of NERATINIB
INHIBITOR->OFF-TARGET
Structure of APD-916
INVERSE AGONIST->TARGET
Structure of A-349821
INHIBITOR -> TARGET
Structure of THIOPERAMIDE
INHIBITOR -> TARGET
Structure of ABT-239
INVERSE AGONIST->TARGET
Structure of 4-(4-(3-((3S)-3-METHYL-1-PIPERIDYL)PROPOXY)PHENYL)PYRIDINE 1-OXIDE
AGONIST -> TARGET
Structure of CLOBENPROPIT
INHIBITOR -> TARGET
Structure of CONESSINE
INHIBITOR -> TARGET
Structure of IMMETHRIDINE
AGONIST -> TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID SUBSTITUTION [1_439] SITE_SPECIFIC DEXFOSFOSERINE VI4F0K069V
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
NIH
NCATS
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