Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Wed Apr 02 19:50:54 GMT 2025
by
admin
on
Wed Apr 02 19:50:54 GMT 2025
|
| Source Materials Class | ORGANISM |
| Source Materials Type | AUTOLOGOUS HUMAN |
| Source Materials State | LIVE GENETICALLY MODIFIED |
| Source Materials Parent | |
| Part | blood |
| Fraction Name | cd4/cd8 entriched t cells |
| Record UNII |
DS272D3LHY
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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| Name | Type | Language | ||
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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DS272D3LHY
Created by
admin on Wed Apr 02 19:50:54 GMT 2025 , Edited by admin on Wed Apr 02 19:50:54 GMT 2025
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PRIMARY | |||
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C211706
Created by
admin on Wed Apr 02 19:50:54 GMT 2025 , Edited by admin on Wed Apr 02 19:50:54 GMT 2025
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PRIMARY | |||
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13279
Created by
admin on Wed Apr 02 19:50:54 GMT 2025 , Edited by admin on Wed Apr 02 19:50:54 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET->CYTOTOXIC T-CELL |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
The cell suspension consists of T lymphocytes (?80%) with greater than 10% of the T lymphocytes expressing the CAR transgene, other cell types (expressing CD16, CD14 and CD19) are present at ?20%, and memory T lymphocyte subsets are phenotypically determined.
The cells exhibit cytotoxicity towards CD19 expressing B lymphocytes upon co-culture
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Agent Modifications
| Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
|---|---|---|---|---|---|
| CULTURED | EXPANSION | BIOLOGICAL |
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HUMAN INTERLEUKIN-2 | FNO32LO217 |
| CULTURE | ACTIVATOR | BIOLOGICAL |
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T CELL TRANSACT, HUMAN | YG578HEY4V |
| LENTIVIRAL TRANSFECTION | TRANSFECTION | GENE MODIFICATION | Resecabtagene autoleucel Lentiviral vector | H8G8TB7VGZ |
Structural Modifications
| Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
|---|---|---|---|---|---|---|
| VECTOR EXPRESSED PROTEIN | Resecabtagene autoleucel expressed anti-CD19 chimeric antigen receptor (CAR) | DE6W42Y7UY | ||||
| INSERTED GENE EXPRESSION VECTOR | Resecabtagene autoleucel transgene insert | 32QJS39Y9P |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| ANTIGEN LOW EXPRESSION | BIOLOGICAL |
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| ANTIGEN LOW EXPRESSION | BIOLOGICAL |
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