NOCICEPTIN RECEPTOR

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:29:14 GMT 2025` Edited by `admin` on `Tue Apr 01 18:29:14 GMT 2025`
Protein Type	RECEPTOR
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DVO6VKD7IJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KAPPA-TYPE 3 OPIOID RECEPTOR

Preferred Name

English

NOCICEPTIN RECEPTOR

Common Name

English

ORPHANIN FQ RECEPTOR

Common Name

English

KOR-3

Common Name

English

NOP Receptor

Common Name

English

nociceptin/orphanin FQ receptor

Common Name

English

Code System Code Type Description

FDA UNII

DVO6VKD7IJ

Created by admin on Tue Apr 01 18:29:14 GMT 2025 , Edited by admin on Tue Apr 01 18:29:14 GMT 2025

PRIMARY

UNIPROT

P41146

Created by admin on Tue Apr 01 18:29:14 GMT 2025 , Edited by admin on Tue Apr 01 18:29:14 GMT 2025

PRIMARY

From	To
1_123	1_200

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_21
N	1_28
N	1_39

Related Record Type Details


					40D3SCR4GZ

PARTIAL AGONIST->TARGET

Comments:

[35S]GTP?S Binding, 21.0 +/- 8.4 simulation

Qualification:

EC50

Amount:


					DZ4NDW1LZX

AGONIST -> TARGET

Amount:


					NT43S9BKJ2

AT-076

INHIBITOR -> TARGET

Interaction Type:

ANTAGONIST


					6XLY6FY7EQ

GRT-6010

AGONIST -> TARGET

Amount:


					44707RLQ6U

MK-5757

INHIBITOR -> TARGET

Amount:


					7AYI9N34FF

AGONIST -> TARGET

Comments:

[35S]GTP?S Binding

Qualification:

EC50

Amount:


					8NMK0UG3HV

MCOPPB

AGONIST -> TARGET

Amount:


					4I67US2V8Q

INHIBITOR -> TARGET

Amount:


					I1X86U5474

SUNOBINOP

AGONIST -> TARGET

Amount:


					5I84488N5B

RADIOLIGAND->TARGET


					8SQP8A30GG

INHIBITOR -> TARGET

Comments:

Engineered Botulinum Toxins that cleaves NOCICEPTIN RECEPTOR

Amount:


					7GDW9S3GN3

AGONIST -> TARGET

Amount:


					QQX8S479YV

DIHYDROETORPHINE

WEAK AGONIST->TARGET

Qualification:

Ki

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_363]				DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL