DIHYDROETORPHINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC[C@@](C)(O)[C@H]1C[C@@]23CC[C@]1(OC)[C@@H]4OC5=C(O)C=CC6=C5[C@]24CCN(C)[C@@H]3C6

InChI

InChIKey=BRTSNYPDACNMIP-FAWZKKEFSA-N

InChI=1S/C25H35NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,17-18,21,27-28H,5,8-14H2,1-4H3/t17-,18-,21-,22-,23-,24+,25-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C25H35NO4
Molecular Weight	413.5497
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Paradoxical relationship between RAVE (relative activity versus endocytosis) values of several opioid receptor agonists and their liability to cause dependence.	2010-04	20228826
Tramadol and dihydroetorphine produce synergistic analgesic effect and postpones acute opiate tolerance in rats.	2005-12-25	16344893
The orvinols and related opioids--high affinity ligands with diverse efficacy profiles.	2004	15032698
Synthesis and biological evaluation of 14-alkoxymorphinans. 20. 14-phenylpropoxymetopon: an extremely powerful analgesic.	2003-09-11	12954070
Binding affinity to and dependence on some opioids in Sf9 insect cells expressing human mu-opioid receptor.	2003-09	12956932
Discriminative stimulus and antinociceptive effects of dihydroetorphine in rhesus monkeys.	2003-04	12601499
Cell death-inducing activity of opiates in human oral tumor cell lines.	2002-05-23	12017290
Biochemical characterisation of newly developed beta-etorphine and beta-dihydroetorphine derivatives.	2002-05-03	12020678
Dihydroetorphine: a potent analgesic: pharmacology, toxicology, pharmacokinetics, and clinical effects.	2002	12481194
Tolerance to analgesia and dependence liability by topical application of dihydroetorphine to hairless rats.	2001-07-06	11448480
Pharmacokinetic and pharmacodynamic evaluations of a potent analgesic, dihydroetorphine, in hairless rat.	2001-02	11160640
A protective effect against undesirable increase of dihydroetorphine permeation through damaged skin by using pressure-sensitive adhesive tape with an ethylene-vinyl acetate co-polymer membrane.	2001-01	11201250

Substance Class	Chemical Created by `admin` on `Mon Mar 31 23:18:10 GMT 2025` Edited by `admin` on `Mon Mar 31 23:18:10 GMT 2025`
Record UNII	QQX8S479YV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IDS-ND-025

Preferred Name

English

DIHYDROETORPHINE

Common Name

English

TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHANOORIPAVINE

Common Name

English

Dihydroetorphine [WHO-DD]

Common Name

English

6,14-ETHENOMORPHINAN-7-METHANOL, 4,5-EPOXY-18,19-DIHYDRO-3-HYDROXY-6-METHOXY-.ALPHA.,17-DIMETHYL-.ALPHA.-PROPYL-, (.ALPHA.R,5.ALPHA.,7.ALPHA.)

Common Name

English

7,8-DIHYDRO-7.ALPHA.-(1-(R)-HYDROXY-1-METHYLBUTYL)-6,14-ENDOETHANOTETRAHYDROORIPAVINE

Systematic Name

English

R-dihydroetorphine

Common Name

English

Classification Tree Code System Code

DEA NO.

9334