Trifluoroacetic acid

Details

Stereochemistry	ACHIRAL
Molecular Formula	C2HF3O2
Molecular Weight	114.0233
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C(F)(F)F

InChI

InChIKey=DTQVDTLACAAQTR-UHFFFAOYSA-N

InChI=1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

HIDE SMILES / InChI

Molecular Formula	C2HF3O2
Molecular Weight	114.0233
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Enols as potent antibacterial agents.	2001-11-19	11677129
Novel synthesis of 4,5-diarylphenanthrenes via C2-C6 cyclization of benzannulated enyne-allenes.	2001-11-16	11701039
A doubly destabilized antiaromatic cyclopentadienyl cation: solvolysis of a 5-trifluoroacetoxy-5-heptafluoropropyl 1,3-cyclopentadiene.	2001-11-16	11701023
Evaluation of detection methods for the reversed-phase HPLC determination of 3',4',5'-trimethoxyflavone in different phytopharmaceutical products and in human serum.	2001-11-14	11705238
Reductive deprotection of N-tritylaziridines.	2001-11-02	11681978
Trapping of a covalent enzyme intermediate in the reaction of Bacillus macerans cyclomaltodextrin glucanyltransferase with cyclomaltohexaose.	2001-11-01	11675025
Palladium complex catalyzed acylation of allylic esters with acylsilanes.	2001-10-31	11673979
Validation of an analytical method for a potent antitumor agent, TZT-1027, in plasma using liquid chromatography-mass spectrometry.	2001-10-25	11678375
Clean-chemistry synthesis of 2-tetralones in a single-stage acylation-cycloalkylation process.	2001-10-19	11597238
Generating multiply charged protein ions by ultrasonic nebulization/multiple channel-electrospray ionization mass spectrometry.	2001-10-15	11681476
Purification of recombinant brain derived neurotrophic factor using reversed phase displacement chromatography.	2001-10-06	11587582
Novel syntheses of 2,3-dihydro-1,5-benzothiazepin-4(5h)-ones and 2h-1,4-benzothiazin-3(4h)-ones.	2001-10-05	11578236
Separation, identification, and quantification of amino acids in L-lysine fermentation potato juices by gas chromatography-mass spectrometry.	2001-10	11688654
Development of a generic method to the solid-phase extraction of acidic compounds from complex matrices.	2001-10	11599607
Synthesis of boronic acid analogues of alpha-amino acids by introducing side chains as electrophiles.	2001-09-21	11559189
Stereoselective synthesis of [13C]methyl 2-[15N]amino-2-deoxy-beta-D-glucopyranoside derivatives.	2001-09-07	11527528
Electrocyclic rearrangement of pentamethylcyclooctapyrimidine-2,4-diones: reaction pathway into a 9,11-diazapentacyclo-[6.4.0.0(1,3).0(2,5).0(4,8)]dodecane system and a 9,11-diazapentacyclo [6.4.0.0(1,3).0(2,6).0(4,8)]dodecane system.	2001-09	11594050
Solution-phase automated synthesis of tripeptide derivatives.	2001-09	11558600
Evaluation of the trifluoromethanosulfonic acid/trifluoroacetic acid/thioanisole cleavage procedure for application in solid-phase peptide synthesis.	2001-09	11558592
Effect of mobile phase acidic additives on enantioselectivity for phenylalanine analogs.	2001-08-24	11572397
Microencapsulation of a synthetic peptide epitope for HTLV-1 in biodegradable poly(D,L-lactide-co-glycolide) microspheres using a novel encapsulation technique.	2001-08-18	11508771
Trifluoroacetic acid activates ATP-sensitive K(+) channels in rabbit ventricular myocytes.	2001-08-03	11478772
Separation of lidocaine and its metabolites by capillary electrophoresis using volatile aqueous and nonaqueous electrolyte systems.	2001-08	11519953
Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Part II. Total synthesis of human big gastrin-II and its C-terminal glycine-extended peptide (G34-Gly sulfate) by the solid-phase segment condensation approach.	2001-08	11515585
Cross-fostering inhalation toxicity study with HCFC-123 in lactating Sprague-Dawley rats.	2001-08	11498800
beta -Helical polymers from isocyanopeptides.	2001-07-27	11474106
19F NMR of trifluoroacetyl-labeled cysteine mutants of myoglobin: structural probes of nitric oxide bound to the H93G cavity mutant.	2001-07-24	11456499
Thermolysis of fluoropolymers as a potential source of halogenated organic acids in the environment.	2001-07-19	11460160
Direct analysis of urinary trans,trans-muconic acid by coupled column liquid chromatography and spectrophotometric ultraviolet detection: method applicability to human urine.	2001-07-15	11486840
Solid-phase library synthesis of alkoxyprolines.	2001-07-10	11442394
Investigations on the liver toxicity of a blend of HCFC-123 (2,2-dichloro-1,1,1-trifluoroethane) and HCFC-124 (2-chloro-1,1,1,2-tetrafluoroethane) in guinea-pigs.	2001-07	11548120
Metabolism of angiotensin I by guinea pig aqueous humor.	2001-07	11478597
Determination of famotidine in low-volume human plasma by normal-phase liquid chromatography/tandem mass spectrometry.	2001-07	11473396
Structure and stereochemistry of triflavanoids containing both ether and carbon-carbon interflavanyl bonds.	2001-07	11423149
Pi-aromatic and sulfur nucleophilic partners in cationic pi-cyclizations: intramolecular amidoalkylation and thioamidoalkylation cyclization via omega-carbinol lactams(1, 2).	2001-06-29	11421795
Analysis of residual trifluoroacetic acid in a phosphate-buffered saline matrix by ion chromatography with suppressed conductivity detection.	2001-06-22	11452994
High-performance liquid chromatography-electrospray ionization mass spectrometry using monolithic capillary columns for proteomic studies.	2001-06-01	11403277
Evaluation of methods aimed at complete removal of template from molecularly imprinted polymers.	2001-06	11445938
Betainium trifluoroacetate.	2001-06	11408698
Normal-phase high-performance liquid chromatographic separations using ethoxynonafluorobutane as hexane alternative. I. Analytical and chiral applications.	2001-05-25	11407575
Density-labelling of cell wall polysaccharides in cultured rose cells: comparison of incorporation of 2H and 13C from exogenous glucose.	2001-05-18	11434375
Chromatographic purification and characterization of B-phycoerythrin from Porphyridium cruentum. Semipreparative high-performance liquid chromatographic separation and characterization of its subunits.	2001-05-11	11403465
About the stereoelectronics of the intramolecular addition of allylsilanes to aldehydes.	2001-05-04	11405469
Comparison of time-frequency distribution techniques for analysis of spinal somatosensory evoked potential.	2001-05	11465894
Solid-Phase synthesis of a dendritic peptide related to a retinoblastoma protein fragment utilizing a combined boc- and fmoc-chemistry approach.	2001-05	11428547
Major lower limb amputation following failed infrainguinal vascular bypass surgery: a prospective study on amputation levels and stump complications.	2001-04	11411002
Trapping of the putative cationic intermediate in the Morin rearrangement with carbon nucleophiles.	2001-02-09	11430103
Pd-catalyzed asymmetric hydrogenation of alpha-fluorinated iminoesters in fluorinated alcohol: a new and catalytic enantioselective synthesis of fluoro alpha-amino acid derivatives.	2001-02-08	11428002
Stereoselective synthesis of dihydropyrone-containing marine natural products. Total synthesis and structural elucidation of (-)-membrenone-C.	2001-01-11	11429853
Small-scale analysis of exopolysaccharides from Streptococcus thermophilus grown in a semi-defined medium.	2001	11602017

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:56:12 GMT 2025` Edited by `admin` on `Mon Mar 31 17:56:12 GMT 2025`
Record UNII	E5R8Z4G708
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-77366

Preferred Name

English

Trifluoroacetic acid

Systematic Name

English

ACETIC ACID, TRIFLUORO-

Common Name

English

TRIFLUOROACETIC ACID [II]

Common Name

English

TRIFLUOROACETIC ACID [HSDB]

Common Name

English

TFA

Common Name

English

ACETIC ACID, 2,2,2-TRIFLUORO-

Common Name

English

TRIFLUOROACETIC ACID [MI]

Common Name

English

PERFLUOROACETIC ACID

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C802