Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H33NO2 |
| Molecular Weight | 391.5457 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC=C4C5=CC=CN=C5)[C@@H]3CC=C2C1
InChI
InChIKey=UVIQSJCZCSLXRZ-UBUQANBQSA-N
InChI=1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
| Molecular Formula | C26H33NO2 |
| Molecular Weight | 391.5457 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002321/WC500112860.pdf
Curator's Comment: description was created based on several sources, including
http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002321/WC500112860.pdf
Abiraterone acetate (trade name Zytiga) is a prodrug to the abiraterone, steroidal compound with antiandrogen activity and a 17 α-hydroxylase/C17,20-lyase (CYP17) inhibitor. It is indicated in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer. Abiraterone acetate is converted in vivo to abiraterone which inhibits CYP17, enzyme expressed in testicular, adrenal, and prostatic tumor tissues and required for androgen biosynthesis. Administration of this agent may suppress testosterone production by both the testes and the adrenals to castrate-range levels. Androgen sensitive prostatic carcinoma responds to treatment that decreases androgen levels. Androgen deprivation therapies, such as treatment with GnRH agonists or orchiectomy, decrease androgen production in the testes but do not affect androgen production by the adrenals or in the tumor.
CNS Activity
Sources: http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002321/WC500112860.pdf
Curator's Comment: Abiraterone was able to cross the blood brain barrier since 14C-abiraterone had been measured in the cerebellum, cerebrum, medulla and spinal cord.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL3522 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20645691 |
110.0 nM [IC50] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ZYTIGA Approved UseIndicated in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer. Launch Date2011 |
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
71.9 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
297 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
85.7 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
12.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
125 mg single, oral dose: 125 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
64.5 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
2000 mg single, oral dose: 2000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
50.2 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
60.6 ng/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
226 ng/mL |
1000 mg 1 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
226 ng/mL |
1000 mg 1 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
365 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
1562 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
330 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
177 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
125 mg single, oral dose: 125 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
461 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
2000 mg single, oral dose: 2000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
315 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
315 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
1173 ng × h/mL |
1000 mg 1 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
993 ng × h/mL |
1000 mg 1 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
17.7 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
18.6 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
13.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
18.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
125 mg single, oral dose: 125 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
15.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
2000 mg single, oral dose: 2000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
|
18.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
18.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/24374856/ |
1000 mg single, oral dose: 1000 mg route of administration: Oral experiment type: SINGLE co-administered: |
ABIRATERONE plasma | Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
|
12 h |
1000 mg 1 times / day steady-state, oral dose: 1000 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
ABIRATERONE plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
Other AEs: Fatigue, Fatigue... Other AEs: Fatigue (grade 1-2, 39%) Sources: Fatigue (grade 3-4, 2.2%) Edema peripheral (grade 1-2, 25%) Pitting edema (grade 1-2, 25%) Generalized edema (grade 1-2, 25%) Pyrexia (grade 1-2, 8.7%) Pyrexia (grade 3-4, 0.6%) Arthritis (grade 1-2, 30%) Arthralgia (grade 1-2, 30%) Joint swelling (grade 1-2, 30%) Joint stiffness (grade 1-2, 30%) Groin pain (grade 1-2, 6.6%) Constipation (grade 1-2, 23%) Diarrhea (grade 1-2, 22%) Dyspepsia (grade 1-2, 11%) Hot flush (grade 1-2, 22%) Hot flush (grade 3-4, 0.2%) Hypertension (grade 1-2, 22%) Hypertension (grade 3-4, 3.9%) Cough (grade 1-2, 17%) Dyspnea (grade 1-2, 12%) Dyspnea (grade 3-4, 2.4%) Insomnia (grade 1-2, 14%) Insomnia (grade 3-4, 0.2%) Contusion (grade 1-2, 13%) Fall (grade 1-2, 5.9%) Upper respiratory tract infection (grade 1-2, 13%) Nasopharyngitis (grade 1-2, 8%) Hematuria (grade 1-2, 10%) Hematuria (grade 3-4, 1.3%) Rash (grade 1-2, 8.1%) |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
Disc. AE: Cardiac failure, AST high... Other AEs: Lymphopenia, Lymphopenia... AEs leading to discontinuation/dose reduction: Cardiac failure (5 patients) Other AEs:AST high (1%) ALT high (1%) Lymphopenia (grade 1-2, 29.3%) Sources: Lymphopenia (grade 3-4, 8.7%) Hyperglycemia (grade 1-2, 50.5%) Hyperglycemia (grade 3-4, 6.5%) ALT high (grade 1-2, 35.9%) ALT high (grade 3-4, 6.1%) AST high (grade 1-2, 33.9%) AST high (grade 3-4, 3.1%) Hypernatremia (grade 1-2, 32.6%) Hypernatremia (grade 3-4, 0.4%) Hypokalemia (grade 1-2, 14.2%) Hypokalemia (grade 3-4, 2.8%) Cardiac failure (grade 3-4, 1.6%) Cardiac failure (grade 5, 2 patients) |
2000 mg 1 times / day multiple, oral Highest studied dose Dose: 2000 mg, 1 times / day Route: oral Route: multiple Dose: 2000 mg, 1 times / day Sources: |
unhealthy Health Status: unhealthy Sex: M Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Hematuria | grade 1-2, 10% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Dyspepsia | grade 1-2, 11% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Dyspnea | grade 1-2, 12% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Contusion | grade 1-2, 13% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Upper respiratory tract infection | grade 1-2, 13% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Insomnia | grade 1-2, 14% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Cough | grade 1-2, 17% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Diarrhea | grade 1-2, 22% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hot flush | grade 1-2, 22% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypertension | grade 1-2, 22% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Constipation | grade 1-2, 23% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Edema peripheral | grade 1-2, 25% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Generalized edema | grade 1-2, 25% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Pitting edema | grade 1-2, 25% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Arthralgia | grade 1-2, 30% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Arthritis | grade 1-2, 30% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Joint stiffness | grade 1-2, 30% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Joint swelling | grade 1-2, 30% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Fatigue | grade 1-2, 39% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Fall | grade 1-2, 5.9% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Groin pain | grade 1-2, 6.6% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Nasopharyngitis | grade 1-2, 8% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Rash | grade 1-2, 8.1% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Pyrexia | grade 1-2, 8.7% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hot flush | grade 3-4, 0.2% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Insomnia | grade 3-4, 0.2% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Pyrexia | grade 3-4, 0.6% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hematuria | grade 3-4, 1.3% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Fatigue | grade 3-4, 2.2% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Dyspnea | grade 3-4, 2.4% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypertension | grade 3-4, 3.9% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| ALT high | 1% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| AST high | 1% Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Cardiac failure | 5 patients Disc. AE |
500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypokalemia | grade 1-2, 14.2% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Lymphopenia | grade 1-2, 29.3% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypernatremia | grade 1-2, 32.6% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| AST high | grade 1-2, 33.9% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| ALT high | grade 1-2, 35.9% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hyperglycemia | grade 1-2, 50.5% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypernatremia | grade 3-4, 0.4% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Cardiac failure | grade 3-4, 1.6% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hypokalemia | grade 3-4, 2.8% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| AST high | grade 3-4, 3.1% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| ALT high | grade 3-4, 6.1% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Hyperglycemia | grade 3-4, 6.5% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Lymphopenia | grade 3-4, 8.7% | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
| Cardiac failure | grade 5, 2 patients | 500 mg 1 times / day steady, oral Recommended Dose: 500 mg, 1 times / day Route: oral Route: steady Dose: 500 mg, 1 times / day Sources: |
unhealthy, 70 years Health Status: unhealthy Age Group: 70 years Sex: M Sources: |
Overview
| CYP3A4 | CYP2C9 | CYP2D6 | hERG |
|---|---|---|---|
OverviewOther
| Other Inhibitor | Other Substrate | Other Inducer |
|---|---|---|
Drug as perpetrator
Drug as victim
| Target | Modality | Activity | Metabolite | Clinical evidence |
|---|---|---|---|---|
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202379Orig1s000ClinPharmR.pdf#page=26 Page: 26.0 |
major | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202379Orig1s000ClinPharmR.pdf#page=26 Page: 26.0 |
minor | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202379Orig1s000ClinPharmR.pdf#page=23 Page: 23.0 |
no | |||
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/nda/2011/202379Orig1s000ClinPharmR.pdf#page=23 Page: 23.0 |
no | |||
| yes | ||||
| yes |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay. | 2014-03 |
|
| Open-label, phase I, pharmacokinetic studies of abiraterone acetate in healthy men. | 2012-06 |
|
| [Abiraterone acetate: a novel therapeutic option in hormone-refractory prostate cancer]. | 2012-02 |
|
| Abiraterone acetate. | 2011-08-01 |
|
| Efficacy of abiraterone acetate in post-docetaxel castration-resistant prostate cancer. | 2010-07 |
Sample Use Guides
1,000 mg (four 250 mg tablets) administered orally once daily in combination with prednisone 5 mg administered orally twice daily. Zytiga must be taken on an empty stomach. No food should be consumed for at least two hours before the dose of Zytiga is taken and for at least one hour after the dose of Zytiga is taken. For patients with baseline moderate hepatic impairment (Child-Pugh Class
B), reduce the Zytiga starting dose to 250 mg once daily. For patients who develop hepatotoxicity during treatment, hold Zytiga until recovery. Retreatment may be initiated at a reduced dose. Zytiga should be discontinued if patients develop severe hepatotoxicity.
Route of Administration:
Oral
Abiraterone acetate (CB 7630) inhibits CYP17 with an IC50 of 110 nM in human testicular microsomes. In Caco-2 cell monolayers abiraterone acetate had a low apparent permeability and was not substrate of P-glycoprotein (P-gp). Abiraterone acetate inhibited P-gp significantly at high concentrations with a 50 % inhibitory concentration (IC50) of 10.8 uM however as abiraterone acetate is rapidly converted to abiraterone, no systemic inhibition of P-gp is expected.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:06:04 GMT 2025
by
admin
on
Mon Mar 31 18:06:04 GMT 2025
|
| Record UNII |
EM5OCB9YJ6
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Preferred Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
EMA ASSESSMENT REPORTS |
ZYTIGA (AUTHORIZED: PROSTATIC NEOPLASMS)
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
||
|
NCI_THESAURUS |
C147923
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DBSALT001173
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
1000818
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
68639
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
4176
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
DTXSID3049043
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
100000124155
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
748121
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
WW-52
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
C68845
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
1100071
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | RxNorm | ||
|
Abiraterone acetate
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
SUB31647
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
9821849
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
CHEMBL271227
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
m1279
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | Merck Index | ||
|
154229-18-2
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
749227
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
EM5OCB9YJ6
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY | |||
|
EM5OCB9YJ6
Created by
admin on Mon Mar 31 18:06:04 GMT 2025 , Edited by admin on Mon Mar 31 18:06:04 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
METABOLIC ENZYME -> NON-SUBSTRATE |
|
||
|
TRANSPORTER -> INHIBITOR |
Abiraterone acetate inhibits Pgp significantly, with an IC50 of 10.8 ?M in vitro.
IC50
|
||
|
TARGET -> INHIBITOR |
NEEDS TO BE ACTIVATE TO ABIRATERONE
|
||
|
EXCRETED UNCHANGED |
FECAL
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
METABOLITE ACTIVE -> PRODRUG |
|
||
|
METABOLITE ACTIVE -> PRODRUG |
|
||
|
|
METABOLITE ACTIVE -> PRODRUG |
|
||
|
METABOLITE ACTIVE -> PRODRUG |
MAJOR
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
||
|
IMPURITY -> PARENT |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| Tmax | PHARMACOKINETIC |
|
|
|||