MELPHALAN FLUFENAMIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H30Cl2FN3O3
Molecular Weight	498.418
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MELPHALAN FLUFENAMIDE

Structure Search

SMILES

CCOC(=O)[C@H](CC1=CC=C(F)C=C1)NC(=O)[C@@H](N)CC2=CC=C(C=C2)N(CCCl)CCCl

InChI

InChIKey=YQZNKYXGZSVEHI-VXKWHMMOSA-N

InChI=1S/C24H30Cl2FN3O3/c1-2-33-24(32)22(16-18-3-7-19(27)8-4-18)29-23(31)21(28)15-17-5-9-20(10-6-17)30(13-11-25)14-12-26/h3-10,21-22H,2,11-16,28H2,1H3,(H,29,31)/t21-,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C24H30Cl2FN3O3
Molecular Weight	498.418
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 20:15:37 UTC 2023` Edited by `admin` on `Fri Dec 15 20:15:37 UTC 2023`
Record UNII	F70C5K4786
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MELPHALAN FLUFENAMIDE

Official Name

English

L-PHENYLALANINE, 4-(BIS(2-CHLOROETHYL)AMINO)-L-PHENYLALANYL-4-FLUORO-, ETHYL ESTER

Systematic Name

English

PRODRUG J1

Code

English

J-1

Code

English

Melphalan flufenamide [WHO-DD]

Common Name

English

J1

Code

English

MFF

Common Name

English

melphalan flufenamide [INN]

Common Name

English

J1 (PRODRUG)

Code

English

J-1 (PRODRUG)

Code

English

MELPHALAN FLUFENAMIDE [USAN]

Common Name

English

ETHYL (2S)-2-((2S)-2-AMINO-3-(4-(BIS(2-CHLOROETHYL)AMINO)PHENYL)PROPANAMIDO)-3-(4-FLUOROPHENYL)PROPANOATE

Systematic Name

English

PRODRUG J-1

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C697

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

NCI_THESAURUS

C1742

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

EU-Orphan Drug

EU/3/15/1463

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

Code System Code Type Description

EPA CompTox

DTXSID40191461

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

PUBCHEM

9935639

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

RXCUI

2531369

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

WIKIPEDIA

Melphalan flufenamide

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

SMS_ID

100000177159

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

USAN

GH-114

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

FDA UNII

F70C5K4786

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

NCI_THESAURUS

C107680

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

CAS

380449-51-4

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

INN

9493

Created by admin on Fri Dec 15 20:15:37 UTC 2023 , Edited by admin on Fri Dec 15 20:15:37 UTC 2023

PRIMARY

Related Record Type Details


					3412470A0V

MELPHALAN FLUFENAMIDE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					S9Q98LTJ9E

DESETHYL-MELPHALAN FLUFENAMIDE

METABOLITE -> PARENT

Amount:


					Q41OR9510P

MELPHALAN

METABOLITE ACTIVE -> PRODRUG

Amount:

Related Record Type Details


					Q41OR9510P

MELPHALAN

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC		`F70C5K4786` MELPHALAN FLUFENAMIDE

Biological Half-life	PHARMACOKINETIC		`F70C5K4786` MELPHALAN FLUFENAMIDE

Tmax	PHARMACOKINETIC		`F70C5K4786` MELPHALAN FLUFENAMIDE		Melphalan flufenamide peak plasma concentrations were reached during the 30-minute infusion. PHARMACOKINETIC