TILIDINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H23NO2
Molecular Weight	273.37
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TILIDINE

Structure Search

SMILES

CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2

InChI

InChIKey=WDEFBBTXULIOBB-WBVHZDCISA-N

InChI=1S/C17H23NO2/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3/h5-8,10-12,15H,4,9,13H2,1-3H3/t15-,17+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H23NO2
Molecular Weight	273.37
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:59:30 UTC 2023` Edited by `admin` on `Fri Dec 15 14:59:30 UTC 2023`
Record UNII	GY33N31E9Y
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TILIDINE

Official Name

English

3-CYCLOHEXENE-1-CARBOXYLIC ACID, 2-(DIMETHYLAMINO)-1-PHENYL-, ETHYL ESTER, (TRANS)-(±)-

Common Name

English

TILIDATE

Common Name

English

TILIDINE [MI]

Common Name

English

TRANS-TILIDINE

Common Name

English

DL-TRANS-TILIDINE

Common Name

English

3-CYCLOHEXENE-1-CARBOXYLIC ACID, 2-(DIMETHYLAMINO)-1-PHENYL-, ETHYL ESTER, (1R,2S)-REL-

Systematic Name

English

tilidine [INN]

Common Name

English

IDS-NT-003

Code

English

Tilidine [WHO-DD]

Common Name

English

(±)-ETHYL TRANS-2-(DIMETHYLAMINO)-1-PHENYL-3-CYCLOHEXENE-1-CARBOXYLATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C67413

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

WHO-VATC

QN02AX01

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

NCI_THESAURUS

C241

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

DEA NO.

9750

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

WHO-ATC

N02AX01

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

Code System Code Type Description

DRUG CENTRAL

2663

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

DRUG BANK

DB13787

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

MESH

D013993

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

ECHA (EC/EINECS)

243-774-7

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

ALTERNATIVE

RXCUI

10597

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

RxNorm

FDA UNII

GY33N31E9Y

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

MERCK INDEX

m10864

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

Merck Index

ECHA (EC/EINECS)

257-522-9

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

SMS_ID

100000082696

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

WIKIPEDIA

TILIDINE

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

CAS

20380-58-9

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

SUPERSEDED

CAS

51931-66-9

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

NCI_THESAURUS

C152628

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

EVMPD

SUB11051MIG

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

INN

2510

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

CHEBI

77823

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

ChEMBL

CHEMBL2220384

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

PUBCHEM

30131

Created by admin on Fri Dec 15 14:59:30 UTC 2023 , Edited by admin on Fri Dec 15 14:59:30 UTC 2023

PRIMARY

Related Record Type Details


					DXT828600R

TILIDINE FUMARATE

SALT/SOLVATE -> PARENT

Amount:


					4YI72J28N9

TILIDINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					PUO0521HZV

CYTOCHROME P450 3A4

METABOLIC ENZYME -> SUBSTRATE

Amount:


					PJ7Z0WL915

TILIDINE PHOSPHATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET->WEAK AGONIST

Comments:

Inhibition of forskolin-induced cAMP accumulation

Qualification:

IC50

Amount:


					2728MV084C

ACTIVE ENANTIOMER->RACEMATE

Amount:


					Y757T3419R

TILIDINE HYDROCHLORIDE HEMIHYDRATE

SALT/SOLVATE -> PARENT

Comments:

APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)

Amount:


					081I12ZA58

CYTOCHROME P450 2C19

METABOLIC ENZYME -> SUBSTRATE

Amount:


					0UY97CSG1T

CYTOCHROME P450 2B6

METABOLIC ENZYME -> SUBSTRATE

Amount:

Related Record Type Details


					58NDD17NUF

METABOLITE ACTIVE -> PRODRUG

Amount:


					7145G6817J

METABOLITE ACTIVE -> PRODRUG

Comments:

After oral intake tilidine is completely absorbed and rapidly metabolised to nortilidine, bisnortilidine. 100 fold more active than Tilidine.

Amount:

Related Record Type Details


					GY33N31E9Y

TILIDINE

ACTIVE MOIETY

Amount: