DENINTUZUMAB MAFODOTIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:40:24 GMT 2025` Edited by `admin` on `Mon Mar 31 22:40:24 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	H5324S1M7H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DENINTUZUMAB MAFODOTIN

Official Name

English

denintuzumab mafodotin [INN]

Preferred Name

English

IMMUNOGLOBULIN G1-KAPPA AURISTATIN F CONJUGATE, ANTI-(HOMOSAPIENS CD19 (B LYMPHOCYTE SURFACE ANTIGEN B4, LEU-12)), HUMANIZED MONOCLONAL ANTIBODY

Common Name

English

SGN-19A

Code

English

DENINTUZUMAB MAFODOTIN [USAN]

Common Name

English

SGN-CD19A

Code

English

Denintuzumab mafodotin [WHO-DD]

Common Name

English

SGNCD19A

Code

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN CD19 ANTIGEN) (HUMAN-MUS MUSCULUS MONOCLONAL HBU12 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL HBU12 .KAPPA.-CHAIN, DIMER, TETRAKIS(THIOETHER) WITH N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL)-1-OXOHEXYL)-N-MET

Common Name

English

Code System Code Type Description

INN

9886

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

PRIMARY

USAN

CD-82

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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WIKIPEDIA

Denintuzumab mafodotin

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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SMS_ID

100000174940

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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ChEMBL

CHEMBL3545371

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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CAS

1399672-02-6

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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FDA UNII

H5324S1M7H

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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NCI_THESAURUS

C105150

Created by admin on Mon Mar 31 22:40:24 GMT 2025 , Edited by admin on Mon Mar 31 22:40:24 GMT 2025

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From	To
1_22	1_97
1_147	1_203
1_264	1_324
1_370	1_428
2_22	2_97
2_147	2_203
2_264	2_324
2_370	2_428
3_23	3_87
3_133	3_193
4_23	4_87
4_133	4_193
1_223	3_213
2_223	4_213
1_229	2_229
1_232	2_232

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					O19V2N6W9T

MAFODOTIN

CONJUGATE COMPONENT->CONJUGATE

Amount:


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET->CONJUGATED TOXIN

Amount:


					0LPG0J327L

CONJUGATE COMPONENT->CONJUGATE

Amount:

Related Record Type Details


					H5324S1M7H

DENINTUZUMAB MAFODOTIN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC		Amount:	CYSTEINYL-MAFODOTIN	B4S8ET206U

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL