FLORBENAZINE F-18

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H32FNO3
Molecular Weight	364.4846
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(OCCC[18F])C=C2CCN3C[C@@H](CC(C)C)[C@H](O)C[C@@H]3C2=C1

InChI

InChIKey=GNKGXQHHUUEYQV-WTHAECTESA-N

InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1/i22-1

HIDE SMILES / InChI

Molecular Formula	C21H32FNO3
Molecular Weight	364.4846
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67549477 | https://www.ncbi.nlm.nih.gov/pubmed/27157484 | https://clinicaltrials.gov/ct2/show/NCT01550484

FLORBENAZINE F-18 is a fluorinated vesicular monoamine transporter type 2 (VMAT-2) ligand for positron-emission tomography. It has completed Phase II/III as a commercial radiopharmaceutical for the early detection and monitoring of neurodegenerative diseases including Parkinson's disease, Alzheimer's disease, and dementia with Lewy bodies.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
Diagnostic accuracy of imaging brain vesicular monoamine transporter type 2 (VMAT2) in clinically uncertain parkinsonian syndrome (CUPS): a 3-year follow-up study in community patients.	2018-11-15	30446576
Management Impact of Imaging Brain Vesicular Monoamine Transporter Type 2 in Clinically Uncertain Parkinsonian Syndrome with 18F-AV133 and PET.	2017-11	28490469
(18)F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons.	2010-01	27157484

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:31:36 GMT 2025` Edited by `admin` on `Mon Mar 31 19:31:36 GMT 2025`
Record UNII	KM31LBX59H
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

FLORBENAZINE (18F)

Preferred Name

English

FLORBENAZINE F-18

Common Name

English

(18F)-FP-(+)-DTBZ

Common Name

English

(2R,3R,11BR)-9-(3-((SUP 18)F)FLUOROPROPOXY)-10-METHOXY-3-(2-METHYLPROPYL)-1,3,4,6,7,11B- HEXAHYDRO-2H-BENZO(A)QUINOLIZIN-2-OL

Common Name

English

DTBZ F-18

Common Name

English

2H-BENZO(A)QUINOLIZIN-2-OL, 9-(3-(FLUORO-(SUP 18)F)PROPOXY)-1,3,4,6,7,11B-HEXAHYDRO-10- METHOXY-3-(2-METHYLPROPYL)-, (2R,3R,11BR)-

Common Name

English

FLORBENAZINE F 18

Official Name

English

(18F)AV 133

Code

English

florbenazine (¹?F) [INN]

Common Name

English

AV-133 F-18

Code

English

Florbenazine (18f) [WHO-DD]

Common Name

English

FLORBENAZINE, F-18

Common Name

English

FLORBENAZINE F 18 [USAN]

Common Name

English

18F-DTBZ

Common Name

English

(18F)AV-133

Code

English

18F-AV-133

Code

English

Code System Code Type Description

NCI_THESAURUS

C171883