RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 19:07:48 GMT 2025` Edited by `admin` on `Tue Apr 01 19:07:48 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	LAO6446UOL
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

RAC-GAMMA SERINE/THREONINE-PROTEIN KINASE

Common Name

English

AKT3

Preferred Name

English

STK-2

Common Name

English

PROTEIN KINASE B GAMMA

Common Name

English

PROTEIN KINASE AKT-3

Common Name

English

AKT-3

Code

English

PKB GAMMA

Common Name

English

PKBG

Common Name

English

RAC-PK-GAMMA

Common Name

English

Code System Code Type Description

UNIPROT

Q9Y243

Created by admin on Tue Apr 01 19:07:48 GMT 2025 , Edited by admin on Tue Apr 01 19:07:48 GMT 2025

PRIMARY

PHAROS

Q9Y243

Created by admin on Tue Apr 01 19:07:48 GMT 2025 , Edited by admin on Tue Apr 01 19:07:48 GMT 2025

PRIMARY

FDA UNII

LAO6446UOL

Created by admin on Tue Apr 01 19:07:48 GMT 2025 , Edited by admin on Tue Apr 01 19:07:48 GMT 2025

PRIMARY

WIKIPEDIA

AKT3

Created by admin on Tue Apr 01 19:07:48 GMT 2025 , Edited by admin on Tue Apr 01 19:07:48 GMT 2025

PRIMARY

From	To
1_58	1_75
1_292	1_306

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
O	1_301
O	1_308

Related Record Type Details


					QI52W1ZIIB

Pifusertib

INHIBITOR -> TARGET

Amount:


					V6SX910Y31

VEVORISERTIB

INHIBITOR -> TARGET

Interaction Type:

ALLOSTERIC INHIBITOR

Qualification:

IC50

Amount:


					2GWV496552

PERIFOSINE

INHIBITOR -> TARGET

Comments:

Inhibits phosphorylation of AKT presumably prevents IP3 binding.

Amount:


					Q4UG565ZYH

Rizavasertib

INHIBITOR -> TARGET

Comments:

serine/threonine kinase inhibitor

Amount:


					0DXG50I4WD

Rupitasertib

INHIBITOR -> TARGET

Amount:


					GWH480321B

GSK-690693

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					51HZG6MP1K

MK-2206 FREE BASE

INHIBITOR -> TARGET

Interaction Type:

ALLOSTERIC

Qualification:

IC50

Amount:


					ZXM835LQ5E

UPROSERTIB

INHIBITOR -> TARGET

Amount:


					WFR23M21IE

CAPIVASERTIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_471]	S	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_304] [1_446]	T	THREONINE PHOSPHATE	3L4WX7B1EI
AMINO ACID SUBSTITUTION	[1_1]	S	N-ACETYLSERINE	W98518XGZ3

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL