COLTUXIMAB RAVTANSINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 23:26:37 GMT 2025` Edited by `admin` on `Mon Mar 31 23:26:37 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	MRS84YT9L2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COLTUXIMAB RAVTANSINE

Official Name

English

coltuximab ravtansine [INN]

Preferred Name

English

Coltuximab ravtansine [WHO-DD]

Common Name

English

ANTI-CD19 HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO DM4

Common Name

English

IMMUNOGLOBULIN G1 (HUMAN-MOUSE MONOCLONAL HUB4 HEAVY CHAIN), DISULFIDE WITH HUMAN-MOUSE MONOCLONAL HUB4 LIGHT CHAIN, DIMER, TETRAAMIDE WITH N2'-(4-((3-CARBOXYPROPYL)DITHIO)-4-METHYL-1-OXOPENTYL)-N2'-DEACETYLMAYTANSINE

Common Name

English

SAR-3419

Common Name

English

SAR3419

Code

English

Code System Code Type Description

INN

9558

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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NCI_THESAURUS

C71009

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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DRUG BANK

DB06342

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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CAS

1269764-99-9

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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FDA UNII

MRS84YT9L2

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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ChEMBL

CHEMBL2109286

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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SMS_ID

300000025299

Created by admin on Mon Mar 31 23:26:37 GMT 2025 , Edited by admin on Mon Mar 31 23:26:37 GMT 2025

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From	To
1_22	1_96
1_147	1_203
1_264	1_324
1_370	1_428
2_22	2_96
2_147	2_203
2_264	2_324
2_370	2_428
3_23	3_87
3_131	3_191
4_23	4_87
4_131	4_191
1_223	3_211
2_223	4_211
1_229	2_229
1_232	2_232

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					IYZ9TI08W3

B-LYMPHOCYTE ANTIGEN CD19

TARGET -> INHIBITOR

Related Record Type Details


					MRS84YT9L2

COLTUXIMAB RAVTANSINE

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	K	Amount:	DM4-SPDB-L-LYSINE	6MDF4WB915

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:ESTIMATE	CHEMICAL