Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H20ClN5O3 |
| Molecular Weight | 461.9 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(CNC(=O)C2=CC(=CN=C2C3=NC=CC=C3)C4=CN=CC(Cl)=C4)N=C1OC
InChI
InChIKey=CKTWQGHVNRYNCM-UHFFFAOYSA-N
InChI=1S/C24H20ClN5O3/c1-32-21-7-6-18(30-24(21)33-2)14-29-23(31)19-10-16(15-9-17(25)13-26-11-15)12-28-22(19)20-5-3-4-8-27-20/h3-13H,14H2,1-2H3,(H,29,31)
| Molecular Formula | C24H20ClN5O3 |
| Molecular Weight | 461.9 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:40:34 UTC 2023
by
admin
on
Sat Dec 16 11:40:34 UTC 2023
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| Record UNII |
O812716S9E
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| Record Status |
Validated (UNII)
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| Record Version |
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300000041499
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DB15028
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1207253-08-4
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O812716S9E
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44633765
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admin on Sat Dec 16 11:40:34 UTC 2023 , Edited by admin on Sat Dec 16 11:40:34 UTC 2023
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
Originator: Merck Sharp & Dohme; Class: Amide, Pyridine, Sleep disorder therapy, Small molecule
Mechanism of Action: Orexin receptor type 2 antagonist; Orphan Drug Status: No; On Fast track: No; New Molecular Entity: Yes; Highest Development Phase: No development reported for Insomnia;
Most Recent Event: No Data Available
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ACTIVE MOIETY |
This article highlights structural modifications the team utilized to drive compound design, as well as in vivo characterization of our 2-SORA clinical candidate, 5-chloro-N-((5,6-dimethoxypyridin-2-yl)methyl)-2,2:5,3-terpyridine-3-carboxamide (MK-1064), in mouse, rat, dog, and rhesus sleep models.
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