U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 20:44:24 GMT 2025
Edited
by admin
on Wed Apr 02 20:44:24 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
PCX6SM5JNT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HRP-02606
Preferred Name English
Tizetatug
INN  
Official Name English
tizetatug [INN]
Common Name English
H-gamma1 heavy chain humanized (1-451) [VH (Homo sapiens IGHV1-69*02 (88.8%) -(IGHD) -IGHJ4*01 (93.3%), CDR-IMGT [8.8.14] (26-35.51-58.97-110)) (1-121) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (218) (122-219), hinge 1-15 (22
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens TACSTD2 (tumor-associated calcium signal transducer 2, membrane component chromosome 1 surface marker 1, M1S1, gastrointestinal tumor-associated antigen GA7331, pancreatic carcinoma marker protein GA733-1, epit
Common Name English
HRP02606
Code English
Immunoglobulin G1, anti-(human tumor-associated calcium signal transducer 2) (human-Mus musculus monoclonal HRP02606 ?1-chain), human-Mus musculus monoclonal HRP02606 ?-chain, dimer
Common Name English
Code System Code Type Description
CAS
2938864-87-8
Created by admin on Wed Apr 02 20:44:25 GMT 2025 , Edited by admin on Wed Apr 02 20:44:25 GMT 2025
PRIMARY
SMS_ID
300000056833
Created by admin on Wed Apr 02 20:44:25 GMT 2025 , Edited by admin on Wed Apr 02 20:44:25 GMT 2025
PRIMARY
FDA UNII
PCX6SM5JNT
Created by admin on Wed Apr 02 20:44:25 GMT 2025 , Edited by admin on Wed Apr 02 20:44:25 GMT 2025
PRIMARY
INN
13306
Created by admin on Wed Apr 02 20:44:25 GMT 2025 , Edited by admin on Wed Apr 02 20:44:25 GMT 2025
PRIMARY
NCI_THESAURUS
C211703
Created by admin on Wed Apr 02 20:44:25 GMT 2025 , Edited by admin on Wed Apr 02 20:44:25 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_148 2_204
2_224 4_214
2_265 2_325
1_148 1_204
2_371 2_429
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
1_224 3_214
1_230 2_230
1_233 2_233
1_265 1_325
1_371 1_429
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_301
N 2_301
Related Record Type Details
Tizetatug Rezetecan
CONJUGATE -> PARENT
TUMOR-ASSOCIATED CALCIUM SIGNAL TRANSDUCER 2
TARGET->LIGAND

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q Amount: PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_451] [2_451] C-TERMINUS K Amount: LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966