PIDOLIC ACID

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C5H7NO3
Molecular Weight	129.114
Optical Activity	( - )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)[C@@H]1CCC(=O)N1

InChI

InChIKey=ODHCTXKNWHHXJC-VKHMYHEASA-N

InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/t3-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C5H7NO3
Molecular Weight	129.114
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.currentscience.ac.in/Volumes/102/02/0288.pdfhttps://www.drugs.com/otc/121041/cleansing-foaming-gel-acne-pro-skin.html | https://www.ncbi.nlm.nih.gov/pubmed/25727335 | https://www.ncbi.nlm.nih.gov/pubmed/21834944 | https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean | http://www.scalp-health.com/zinc-pca.htm
Curator's Comment: description was created based on several sources, including http://www.cir-safety.org/sites/default/files/pca.pdf

Zinc Pidolate (Zinc PCA) is a topical skin product with purifying, astingent, anti-inflammatory, antiseptic activity. It has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. Zinc Pidolate has also being shown to be effective against halitosis. Zinc PCA prevents the UV-induced MMP-1 production in vitro by suppressing the activation of AP-1. Zinc PCA was also able to enhance type I collagen synthesis in NHDFs, by increasing the expression of the mRNA encoding the ascorbic acid transporter SVCT2 in non-UV irradiated NHDFs, which suggests its promising effect against not only photoaged skin but also for the simple atrophic change of intrinsic skin ageing. Zinc PCA is able to suppress sebum secretion by inhibiting 5-α reductase in hyperseborrhea, to suppress body odor by forming zinc salts with short-chain fatty acids, to suppress wrinkles by inhibiting AP-1 to and inhibit bacterial growth including acne related Propionibacterium acnes.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium-dependent vitamin C transporter 2 5 Target ID: CHEMBL3271 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1447
Collagen alpha-1(I) chain 11 Target ID: P02452\|\|\|Q15176\|\|\|Q9UML6 Gene ID: 1277.0 Gene Symbol: COL1A1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1447
Transcription factor AP1 6 Target ID: CHEMBL2111421 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21834944	Activator 1447
Propionibacterium acnes 6 Target ID: CHEMBL612639 Sources: http://www.in-cosmetics.com/__novadocuments/4317 \| https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean	Inhibitor 8504
Steroid 5-alpha-reductase 15 Target ID: CHEMBL2363075 Sources: https://www.ulprospector.com/en/na/PersonalCare/Detail/6637/223524/EcoCare-Zinclean \| www.google.com/patents/US20090203628 \| http://www.in-cosmetics.com/__novadocuments/4317	Inhibitor 8504

Conditions

Condition	Modality	Highest Phase	Product
Acne 100 Sources: https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=cab1d71c-e017-4ff3-853b-b0e47dc1ee79&type=display http://www.solabia.com/Produto_7,1/Cosmetics/Zincidone.html http://www.scalp-health.com/zinc-pca.htm	Preventing	Approved 8583	CLEANSING FOAMING GEL ACNE PRO SKIN- zinc pidolate gel Approved Use Lange Gel will turn into foam, during application. It will cleanse skin thoroughly without any dryness effect, in order to avoid hyperseboohea phenomenon, a main cause of acne. Launch Date 2012
Halitosis 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25727335	Primary	Phase I 438	Unknown Approved Use Unknown
Seborrhea 11 Sources: http://www.in-cosmetics.com/__novadocuments/4317 http://www.scalp-health.com/zinc-pca.htm http://www.solabia.com/Produto_7,1/Cosmetics/Zincidone.html http://cosmetics.specialchem.com/product/i-ecochem-ecocare-zinclean	Primary	Approved 8583	EcoCare™ Zinclean Approved Use Use in anti-dandruff shampoos
Dry skin 6 Sources: http://www.cir-safety.org/sites/default/files/pca.pdf	Primary	Approved 8583	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
CFSUM1 and CFSUM2 in urine from patients with chronic fatigue syndrome are methodological artefacts.	2006-02	16095585
Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques.	2005-11-04	16091362
Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.).	2005-09-25	16140598
Synthesis of 1,3-dioxo-hexahydropyrido[1,2-c][1,3]diazepine carboxylates, a new bicyclic skeleton formed by ring expansion-RCM methodology.	2005-09-21	16136256
Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme.	2005-09	16084398
Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.	2005-08-07	16032366
Nanoparticles on the basis of highly functionalized dextrans.	2005-08-03	16045324
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.	2005-08-02	16004974
Emerging roles of apelin in biology and medicine.	2005-08	15907343
CLPM: a cross-linked peptide mapping algorithm for mass spectrometric analysis.	2005-07-15	16026606
Total synthesis of pinnamine and anatoxin-a via a common intermediate. A caveat on the anatoxin-a endgame.	2005-07-08	15989354
The removal of pyroglutamic acid from monoclonal antibodies without denaturation of the protein chains.	2005-07-01	15958188
Acetaminophen-induced anion gap metabolic acidosis and 5-oxoprolinuria (pyroglutamic aciduria) acquired in hospital.	2005-07	15983968
Recurrent high anion gap metabolic acidosis secondary to 5-oxoproline (pyroglutamic acid).	2005-07	15983950
Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom.	2005-07	15876444
Biomarker metabolites capturing the metabolite variance present in a rice plant developmental period.	2005-05-31	15927065
Bromophenols coupled with derivatives of amino acids and nucleosides from the red alga Rhodomela confervoides.	2005-05	15921411
Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.	2005-04	15615696
Preparation and reactivity of aminoacyl pyroglutamates. Facile synthesis of 10-membered-ring cyclic dipeptides derived from 1,4-diaminobutyric and glutamic acids.	2005-03	15635648
Physiological and pathological aspects of GSH metabolism.	2005-02	15981742
A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition.	2005	15714601
The computer modelling of human TRH receptor, TRH and TRH-like peptides.	2005	15544424
Alpha-tocopherol pro-vitamins: synthesis, hydrolysis and accumulation in rabbit ear skin.	2004-10-19	15451598
Discrepin, a new peptide of the sub-family alpha-ktx15, isolated from the scorpion Tityus discrepans irreversibly blocks K+ -channels (IA currents) of cerebellum granular cells.	2004-10-15	15369825
Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells.	2004-09-28	15379548
The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography-micro-electrospray ionization-tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent.	2004-09-21	15351054
Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions.	2004-09	15471563
Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).	2004-09	15183349
Glutamine in commercial liquid nutritional products.	2004-08-11	15291459
Integrative annotation of 21,037 human genes validated by full-length cDNA clones.	2004-06	15103394
Mass spectrometric analysis of posttranslational modifications of a carrot extracellular glycoprotein.	2004-05-25	15147212
Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.	2004-05-12	15134346
Synthesis of (2S,3R)-[3',3',3'-2H3]-valine and (2S,3S)-4-fluorovaline.	2004-05-07	15105921
Origin of diastereoselection in the hydrosilylation of chiral N-acyliminium intermediates derived from pyroglutamic acid.	2004-04-26	15114576
Preventing the spontaneous modification of an HLA-A2-restricted peptide at an N-terminal glutamine or an internal cysteine residue enhances peptide antigenicity.	2004-04-13	15076134
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.	2004-04-09	15063747
Synthesis of (2S,3S)-3'-fluoroisoleucine.	2004-03-07	14985821
Chemical characterization of a lambda I amyloid protein isolated from formalin-fixed and paraffin-embedded tissue sections.	2004-03	15185499
Unexplained metabolic acidosis in critically ill patients: the role of pyroglutamic acid.	2004-03	14685659
Identification of endogenous phosphorylation sites of bovine medium and low molecular weight neurofilament proteins by tandem mass spectrometry.	2004-02-24	14967049
Human glutaminyl cyclase and bacterial zinc aminopeptidase share a common fold and active site.	2004-02-10	15028118
Toward the synthesis of pyroglutamate lauroyl ester: biocatalysis versus chemical catalysis.	2004-02	15049361
Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation-implications for immunological studies.	2004-02	14725790
Expression, purification, and characterization of avian Thy-1 from Lec1 mammalian and Tn5 insect cells.	2004-02	14711516
[Characteristics of pyrrolidone pharmacokinetics in rats].	2004-01-28	14743713
N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.	2004-01	14709619
Pressure/temperature combined treatments of precursors yield hormone-like peptides with pyroglutamate at the N terminus.	2003-12-31	14690402
Determination of the post-translational modifications of salivary acidic proline-rich proteins.	2003-04	15621862
Characterizing degradation products of peptides containing N-terminal Cys residues by (off-line high-performance liquid chromatography)/matrix-assisted laser desorption/ionization quadrupole time-of-flight measurements.	2003	14608624
Human seminal relaxin is a product of the same gene as human luteal relaxin.	1992-05	1572287

Patents

Sample Use Guides

In Vivo Use Guide

Topical, as a compontent of lotions, creams and other cosmetic products.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 07:52:53 GMT 2025` Edited by `admin` on `Wed Apr 02 07:52:53 GMT 2025`
Record UNII	SZB83O1W42
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PCA	Locators: INCI Naming Organization: INCI Sources:

Preferred Name

English

PIDOLIC ACID

Official Name

English

GLP

Common Name

English

L-PYROGLUTAMIC ACID

Common Name

English

PYROGLUTAMIC ACID

Common Name

English

5-OXO-L-PROLINE

Systematic Name

English

AJIDEW A-100

Brand Name

English

Pidolic acid [WHO-DD]

Common Name

English

PYROGLUTAMIC ACID, L-

Common Name

English

L-PYRROLIDONE CARBOXYLIC ACID

Common Name

English

5-L-OXOPROLINE

Common Name

English

5-OXOPROLINE

Common Name

English

L-PCA

Common Name

English

PYROGLUTAMATE

Common Name

English

PYROGLU

Common Name

English

pidolic acid [INN]

Common Name

English

PIDOLIDONE

Brand Name

English

L-PYROGLUTAMIC ACID [MI]

Common Name

English

5-OXO-2-PYRROLIDINECARBOXYLIC ACID

Systematic Name

English

(-)-2-PYRROLIDONE-5-CARBOXYLIC ACID

Systematic Name

English

PYROGLUTAMIC ACID [USP-RS]

Common Name

English

GLUTIMIC ACID

Common Name

English

NSC-143034

Code

English

NSC-760414

Code

English

Classification Tree Code System Code

LOINC

75089-3