Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C16H17N3S |
| Molecular Weight | 283.391 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(C)CC1=CC=CC=C1SC2=CC=C(C=C2N)C#N
InChI
InChIKey=UVWLEPXXYOYDGR-UHFFFAOYSA-N
InChI=1S/C16H17N3S/c1-19(2)11-13-5-3-4-6-15(13)20-16-8-7-12(10-17)9-14(16)18/h3-9H,11,18H2,1-2H3
| Molecular Formula | C16H17N3S |
| Molecular Weight | 283.391 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Depressive symptoms in PD correlate with higher 5-HTT binding in raphe and limbic structures. | 2010-11-23 |
|
| Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. | 2010-11 |
|
| Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study. | 2010-10 |
|
| Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [11C] DASB binding in the living human brain. | 2010-08-01 |
|
| Cerebral serotonin transporter binding is inversely related to body mass index. | 2010-08-01 |
|
| Mapping of serotonin transporters by positron emission tomography with [11C]DASB in conscious common marmosets: comparison with rhesus monkeys. | 2010-08 |
|
| Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. | 2010-07 |
|
| Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging study. | 2010-06 |
|
| Cognitive impact of genetic variation of the serotonin transporter in primates is associated with differences in brain morphology rather than serotonin neurotransmission. | 2010-05 |
|
| A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. | 2010-03-03 |
|
| Imaging serotonergic transmission with [11C]DASB-PET in depressed and non-depressed patients infected with HIV. | 2010-02-01 |
|
| Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. | 2010-02 |
|
| Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study. | 2010-01-01 |
|
| Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. | 2009-10-01 |
|
| Simple and rapid preparation of [11C]DASB with high quality and reliability for routine applications. | 2009-09 |
|
| Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter. | 2009-09 |
|
| Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. | 2009-08-12 |
|
| Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease. | 2009-08 |
|
| A probabilistic approach to delineating functional brain regions. | 2009-06 |
|
| High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. | 2009-06 |
|
| Behavioral and neurobiological characteristics influencing social hierarchy formation in female cynomolgus monkeys. | 2009-02-18 |
|
| Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB. | 2008-09-15 |
|
| Seasonal variation in human brain serotonin transporter binding. | 2008-09 |
|
| Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls. | 2008-08 |
|
| Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study. | 2008-06 |
|
| Metabolism and autoradiographic evaluation of [(18)F]FE@CIT: a Comparison with [(123)I]beta-CIT and [(123)I]FP-CIT. | 2008-05 |
|
| Evaluation of non-uniform weighting in non-linear regression for pharmacokinetic neuroreceptor modelling. | 2008-02 |
|
| 5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB. | 2007-12 |
|
| Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. | 2007-10-15 |
|
| Relationship between neuroticism personality trait and serotonin transporter binding. | 2007-09-15 |
|
| Effects of increased endogenous serotonin on the in vivo binding of [11C]DASB to serotonin transporters in conscious monkey brain. | 2007-09 |
|
| Human 5-HT transporter availability predicts amygdala reactivity in vivo. | 2007-08-22 |
|
| 3-Amino-4-(2-((4-[18F]fluorobenzyl)methylamino)methylphenylsulfanyl)benzonitrile, an F-18 fluorobenzyl analogue of DASB: synthesis, in vitro binding, and in vivo biodistribution studies. | 2007-08-21 |
|
| Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [(11)C] DASB positron emission tomography study. | 2007-08-15 |
|
| A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Göttingen minipig brain. | 2007-07 |
|
| Misunderstandings about how to choose a reference region. | 2007-06-01 |
|
| Effect on [11C]DASB binding after tranylcypromine-induced increase in serotonin concentration: positron emission tomography studies in monkeys and rats. | 2007-06 |
|
| Brain serotonin transporter binding in non-depressed patients with Parkinson's disease. | 2007-05 |
|
| PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. | 2007-01 |
|
| In vivo quantification of serotonin transporters using [(11)C]DASB and positron emission tomography in humans: modeling considerations. | 2007-01 |
|
| Reduced availability of serotonin transporters in obsessive-compulsive disorder correlates with symptom severity - a [11C]DASB PET study. | 2007 |
|
| Midbrain serotonin transporter binding potential measured with [11C]DASB is affected by serotonin transporter genotype. | 2007 |
|
| Metabolite considerations in the in vivo quantification of serotonin transporters using 11C-DASB and PET in humans. | 2006-11 |
|
| Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. | 2006-08-01 |
|
| Acute occupancy of brain serotonin transporter by sertraline as measured by [11C]DASB and positron emission tomography. | 2006-05-01 |
|
| The serotonin transporter in rhesus monkey brain: comparison of DASB and citalopram binding sites. | 2006-05 |
|
| Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. | 2006-05 |
|
| Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys. | 2006-04-26 |
|
| Time course of in vivo 5-HTT transporter occupancy by fluvoxamine. | 2006-04 |
|
| PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. | 2006-02 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:30:48 GMT 2025
by
admin
on
Mon Mar 31 23:30:48 GMT 2025
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| Record UNII |
PP549Z0645
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| Record Status |
Validated (UNII)
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| Record Version |
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PP549Z0645
Created by
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627490-01-1
Created by
admin on Mon Mar 31 23:30:48 GMT 2025 , Edited by admin on Mon Mar 31 23:30:48 GMT 2025
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10446567
Created by
admin on Mon Mar 31 23:30:48 GMT 2025 , Edited by admin on Mon Mar 31 23:30:48 GMT 2025
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DASB
Created by
admin on Mon Mar 31 23:30:48 GMT 2025 , Edited by admin on Mon Mar 31 23:30:48 GMT 2025
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DTXSID001027386
Created by
admin on Mon Mar 31 23:30:48 GMT 2025 , Edited by admin on Mon Mar 31 23:30:48 GMT 2025
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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BINDER->LIGAND | |||
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SALT/SOLVATE -> PARENT |
