U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 20:51:02 GMT 2025
Edited
by admin
on Tue Apr 01 20:51:02 GMT 2025
Protein Type RECEPTOR
Protein Sub Type REUPTAKE RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
CJZ26L1EGI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM-DEPENDENT SEROTONIN TRANSPORTER
Common Name English
5HT TRANSPORTER
Preferred Name English
5HTT
Common Name English
SERT
Common Name English
SOLUTE CARRIER FAMILY 6 MEMBER 4
Common Name English
SLC6A4
Common Name English
HTT
Common Name English
SEROTONIN REUPTAKE TRANSPORTER
Common Name English
Code System Code Type Description
FDA UNII
CJZ26L1EGI
Created by admin on Tue Apr 01 20:51:03 GMT 2025 , Edited by admin on Tue Apr 01 20:51:03 GMT 2025
PRIMARY
From To
1_200 1_209
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_208
N 1_217
Related Record Type Details
Structure of Dextromethorphan
INHIBITOR -> TARGET
Rat
Ki
Structure of PAROXETINE
INHIBITOR -> TARGET
Structure of BUTYLONE
INHIBITOR -> TARGET
Structure of ZIMELDINE
INHIBITOR -> TARGET
BINDING
IC50
Structure of JZ-IV-10
INHIBITOR -> TRANSPORTER
Structure of PRC200-SS
INHIBITOR -> TRANSPORTER
Structure of FLUOXETINE
INHIBITOR -> TARGET
Structure of RO-15-8081 FREE BASE
INHIBITOR -> TARGET
Structure of WF-23
INHIBITOR -> TARGET
Structure of PSEUDOEPHEDRINE
INHIBITOR -> TARGET
Structure of RTI-120
INHIBITOR -> TRANSPORTER
Structure of EXP-561
INHIBITOR -> TARGET
Structure of 2'-HYDROXYCOCAINE
LIGAND->TRANSPORTER
Structure of NIRAPARIB
INHIBITOR -> TARGET
IN-VITRO
IC50
Structure of Lumateperone
ANTAGONIST->TARGET
Ki
Structure of CTP-347
INHIBITOR -> TARGET
Structure of Amitriptyline
INHIBITOR -> TARGET
Structure of VENLAFAXINE
INHIBITOR -> TARGET
IC50
Structure of BUTYLONE
SUBSTRATE -> TARGET
INDUCES SEROTONIN RELEASE; NOT A DAT SUBSTRATE
EC50
Structure of 6-FLUORO-DMT
LIGAND->TRANSPORTER
Structure of TH-PVP
INHIBITOR -> TARGET
nhibition of [3H]neurotransmitter uptake IC50 ± sem (??).
IC50
Structure of TRAMADOL, (+)-
INHIBITOR -> TARGET
Structure of 403U76 FREE BASE
INHIBITOR -> TARGET
Structure of MDMC
INHIBITOR -> TARGET
Structure of TRAMADOL
INHIBITOR -> TARGET
(+)-Tramadol inhibits serotonin reuptake
Structure of LY-367265
INHIBITOR -> TARGET
Ki
Structure of RTI-177
LIGAND->TRANSPORTER
Structure of FENFLURAMINE
SUBSTRATE -> TRANSPORTER
STIMULATES SEROTONIN RELEASE.
Structure of 2C-B-AMINOREX
SUBSTRATE -> TRANSPORTER
Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard.
Structure of CYANODOTHIEPIN
INHIBITOR -> TRANSPORTER
Structure of Duloxetine
INHIBITOR -> TARGET
Structure of SERTRALINE
INHIBITOR -> TARGET
Structure of Pudafensine
INHIBITOR -> TARGET
IC50
Structure of 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine
INHIBITOR -> TRANSPORTER
Structure of Siponimod
LIGAND->OFF TARGET
IC50
Structure of INDOPAN
INHIBITOR -> TARGET
From Rat Membrane Studies
Structure of CITALOPRAM
INHIBITOR -> TARGET
BINDING
IC50
Structure of LITOXETINE
INHIBITOR -> TARGET
Structure of 6-APB
WEAK INHIBITOR->TARGET
IC50
Structure of PSN-602
INHIBITOR -> TARGET
Structure of PPPA
INHIBITOR -> TRANSPORTER
Structure of ESCITALOPRAM
INHIBITOR -> TARGET
Structure of 3-METHYL-PCPY
INHIBITOR -> TRANSPORTER
Structure of Vortioxetine
INHIBITOR -> TARGET
BINDING
Ki
Structure of 4-HYDROXY-N-METHYL-N-ETHYLTRYPTAMINE
INHIBITOR->OFF-TARGET
Structure of IMIPRAMINE
INHIBITOR -> TARGET
Structure of Serotonin
SUBSTRATE -> TARGET
BINDING
IC50
Structure of N-METHYL-PPPA
INHIBITOR -> TRANSPORTER
Structure of FLUVOXAMINE
INHIBITOR -> TARGET
Kd
Structure of Ro-035939 free base
INHIBITOR -> TARGET
Based on impramine
Structure of DA-8031
INHIBITOR -> TARGET
Structure of RTI-353
INHIBITOR -> TARGET
Structure of DESVENLAFAXINE
INHIBITOR -> TARGET
IC50
Structure of IP-2018
INHIBITOR -> TARGET
Structure of MIDOMAFETAMINE, (R)-
INHIBITOR -> TARGET
IC50
Structure of DASB
LIGAND->BINDER
Structure of Stacofylline
INHIBITOR -> TARGET
Structure of MIDOMAFETAMINE
INHIBITOR -> TARGET
Inhibition of [3H]Neurotransmitter Uptake. May reverse flow of serotonin leading to release.
IC50
Structure of PAROXETINE
INHIBITOR -> TARGET
Structure of UK-390957
INHIBITOR -> TARGET
Structure of 5-METHOXY-N,N-DIETHYLTRYPTAMINE
INHIBITOR -> TARGET
Structure of DESVENLAFAXINE, (-)-
INHIBITOR -> TARGET
Structure of 5-APB
INHIBITOR -> TARGET
Ki
Structure of Imipramine H-3
RADIOLIGAND->TARGET
Kd
Structure of DASB C-11
TARGET->RADIOLIGAND
Structure of RTI-112
INHIBITOR -> TRANSPORTER
IN-VITRO
Structure of 6-METHYL-MDA
INHIBITOR -> TRANSPORTER
IN RAT
Structure of BGC-20-1259
INHIBITOR -> TARGET
IC50
Structure of AFM C-11
RADIOLIGAND->TARGET

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_611] SITE_SPECIFIC DEXFOSFOSERINE VI4F0K069V
AMINO_ACID_SUBSTITUTION [1_47] [1_142] SITE_SPECIFIC TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO_ACID_SUBSTITUTION [1_613] [1_616] SITE_SPECIFIC THREONINE PHOSPHATE 3L4WX7B1EI
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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