MUSCARINIC ACETYLCHOLINE RECEPTOR M5

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:59:26 GMT 2025` Edited by `admin` on `Tue Apr 01 16:59:26 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	QQ0IJ5P4GV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MUSCARINIC ACETYLCHOLINE RECEPTOR M5

Common Name

English

CHRM5

Preferred Name

English

M5

Common Name

English

Code System Code Type Description

UNIPROT

P08912

Created by admin on Tue Apr 01 16:59:26 GMT 2025 , Edited by admin on Tue Apr 01 16:59:26 GMT 2025

PRIMARY

PHAROS

P08912

Created by admin on Tue Apr 01 16:59:26 GMT 2025 , Edited by admin on Tue Apr 01 16:59:26 GMT 2025

PRIMARY

FDA UNII

QQ0IJ5P4GV

Created by admin on Tue Apr 01 16:59:26 GMT 2025 , Edited by admin on Tue Apr 01 16:59:26 GMT 2025

PRIMARY

From	To
1_103	1_183

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_8

Related Record Type Details


					WV3E0S3IQB

VELUFENACIN

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					98IW5HAV1N

VEDACLIDINE

INHIBITOR -> TARGET

Amount:


					K17VY42F6C

ACLIDINIUM

INHIBITOR -> TARGET

Qualification:

Ki

Amount:


					G2AE2VE07O

REVEFENACIN

INHIBITOR -> TARGET

Interaction Type:

BINDING

Qualification:

Kd

Amount:


					838F01T721

PALIPERIDONE

NON-INHIBITOR->OFF TARGET

Interaction Type:

NON-INHIBITOR

Qualification:

Ki

Amount:


					NVJ76B897D

METHOCTRAMINE FREE BASE

INHIBITOR -> TARGET

Comments:

Membranes from transfected CHO cells

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					7C0697DR9I

ATROPINE

INHIBITOR -> TARGET

Amount:


					A6X64T4LZ4

THRX-195518

INHIBITOR -> TARGET

Comments:

THRX-195518 possesses activity at target muscarinic receptors that was slightly lower (approximately one-third to one-tenth) than revefenacin.

Interaction Type:

BINDING

Qualification:

Ki

Amount:


					WHE7A56U7K

TOLTERODINE

INHIBITOR -> TARGET

Amount:


					5ASJ6HUZ7D

DOXEPIN

INHIBITOR -> TARGET

Amount:


					L6UH7ZF8HC

RISPERIDONE

NON-INHIBITOR->OFF TARGET

Amount:


					R9X77R42FN

MILAMELINE

AGONIST -> TARGET

Amount:


					ZH1ZWF5Q3P

VU-0238429

ACTIVATOR -> TARGET

Comments:

selective positive allosteric modulator

Interaction Type:

ALLOSTERIC ACTIVATOR

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_501] [1_505]				THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL