ATROPINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C17H23NO3
Molecular Weight	289.3694
Optical Activity	( + / - )
Defined Stereocenters	3 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ATROPINE

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)C3=CC=CC=C3

InChI

InChIKey=RKUNBYITZUJHSG-SPUOUPEWSA-N

InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15+,16?

HIDE SMILES / InChI

Molecular Formula	C17H23NO3
Molecular Weight	289.3694
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	3 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:28:01 UTC 2023` Edited by `admin` on `Fri Dec 15 16:28:01 UTC 2023`
Record UNII	7C0697DR9I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATROPINE

Common Name

English

ATROPINE [VANDF]

Common Name

English

ATROPINE [USP MONOGRAPH]

Common Name

English

ATROPINE COMPONENT OF ATNAA

Common Name

English

(±)-HYOSCYAMINE

Common Name

English

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-(3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER

Common Name

English

ATROPEN

Brand Name

English

ATROPINUM [HPUS]

Common Name

English

ATROPINE COMPONENT OF DUODOTE

Common Name

English

ATROPINE [ORANGE BOOK]

Common Name

English

DUODOTE COMPONENT ATROPINE

Common Name

English

ATROPINE ((±)-)

Common Name

English

(3-ENDO)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL TROPATE

Common Name

English

ATROPINE [MI]

Common Name

English

ATROPINE, (±)-

Common Name

English

ATNAA COMPONENT ATROPINE

Common Name

English

ATROPINE [GREEN BOOK]

Common Name

English

ATROPINE [EP MONOGRAPH]

Common Name

English

ATROPINE [EP IMPURITY]

Common Name

English

Atropine [WHO-DD]

Common Name

English

ATROPINE [MART.]

Common Name

English

ATROPINUM

Common Name

English

BENZENEACETIC ACID, .ALPHA.-(HYDROXYMETHYL)-8-METHYL-8-AZABICYCLO(3.2.1)OCT-3-YL ESTER, ENDO-(±)-

Common Name

English

HOMATROPINE HYDROBROMIDE IMPURITY D [EP IMPURITY]

Common Name

English

1.ALPHA.H,5.ALPHA.H-TROPAN-3.ALPHA.-OL (±)-TROPATE (ESTER)

Common Name

English

ATROPINE [USP-RS]

Common Name

English

DL-HYOSCYAMINE

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000175370

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NDF-RT

N0000000125

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ATC

A03CB03

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-VATC

QA03BA01

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

LIVERTOX

74

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NDF-RT

N0000175574

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ATC

S01FA01

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NDF-RT

N0000000125

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NDF-RT

N0000000125

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NCI_THESAURUS

C29704

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ATC

A03BA01

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-VATC

QS01FA01

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

CFR

21 CFR 310.533

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

4.2

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

CFR

21 CFR 520.2520A

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-VATC

QA03CB03

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

21.5

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

1.3

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

WHO-ATC

S01BB01

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

NDF-RT

N0000175700

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

Code System Code Type Description

FDA UNII

7C0697DR9I

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

CHEBI

57858

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

DAILYMED

7C0697DR9I

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

MESH

D001285

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

LACTMED

Atropine

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

CAS

51-55-8

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

WIKIPEDIA

ATROPINE

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

RS_ITEM_NUM

1044990

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

DRUG CENTRAL

260

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

NCI_THESAURUS

C28840

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

EVMPD

SUB00621MIG

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

ChEMBL

CHEMBL517712

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

ECHA (EC/EINECS)

200-104-8

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

CHEBI

78734

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

DRUG BANK

DB00572

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

HSDB

2199

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

MERCK INDEX

m2136

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

Merck Index

RXCUI

1223

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

RxNorm

EPA CompTox

DTXSID4020113

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

SMS_ID

100000085031

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

CHEBI

16684

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

IUPHAR

320

Created by admin on Fri Dec 15 16:28:01 UTC 2023 , Edited by admin on Fri Dec 15 16:28:01 UTC 2023

PRIMARY

Related Record Type Details


					6VKW7R97ZU

ATROPINE HYDROBROMIDE

SALT/SOLVATE -> PARENT

Amount:


					03J5ZE7KA5

ATROPINE SULFATE

SALT/SOLVATE -> PARENT

Amount:


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					W3JX5KZ4V2

MUSCARINIC ACETYLCHOLINE RECEPTOR M3

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					U87RX375T5

MUSCARINIC ACETYLCHOLINE RECEPTOR M2

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					ONY583280Z

OCT-1

TRANSPORTER -> INHIBITOR


					V3203SI72M

HYOSCYAMINE, (+)-

ENANTIOMER -> RACEMATE

Amount:


					9L54745ZWE

ATROPINE TARTRATE

SALT/SOLVATE -> PARENT

Amount:


					KAE4PSB0Z3

ATROPINE SULFATE ANHYDROUS

SALT/SOLVATE -> PARENT

Amount:


					76S2JPL145

ATROPA BELLA-DONNA LEAF

PARENT -> CONSTITUENT ALWAYS PRESENT

Amount:


					8HOL4T03PN

MUSCARINIC ACETYLCHOLINE RECEPTOR M4

TARGET -> INHIBITOR

Amount:


					PX44XO846X

ENANTIOMER -> RACEMATE

Amount:


					EUF58V826B

ATROPINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					QQ0IJ5P4GV

MUSCARINIC ACETYLCHOLINE RECEPTOR M5

TARGET -> INHIBITOR

Amount:


					2KC7KP5BGA

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-4

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					8HOL4T03PN

MUSCARINIC ACETYLCHOLINE RECEPTOR M4

TARGET -> INHIBITOR

Comments:

Atropine is a non-specific antagonist for muscarinic acetylcholine receptor.

Qualification:

IC50

Amount:


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					V23K99CV7G

MUSCARINIC ACETYLCHOLINE RECEPTOR M1

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					3Y03IC177D

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					9RM4U80765

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					SN61DB9OW3

METABOLITE -> PARENT

Qualification:

URINE

Amount:

Related Record Type Details


					BEW7469QZ0

HOMATROPINE HYDROBROMIDE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					7C0697DR9I

ATROPINE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC