Mevrometostat

Investigational

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H24Cl2N2O5
Molecular Weight	467.342
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO[C@H](C1COC1)C2=C(Cl)C3=C(CCN(CC4=C(OC)C=C(C)NC4=O)C3=O)C(Cl)=C2

InChI

InChIKey=RXCVUHMIWHRLDF-HXUWFJFHSA-N

InChI=1S/C22H24Cl2N2O5/c1-11-6-17(29-2)15(21(27)25-11)8-26-5-4-13-16(23)7-14(19(24)18(13)22(26)28)20(30-3)12-9-31-10-12/h6-7,12,20H,4-5,8-10H2,1-3H3,(H,25,27)/t20-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H24Cl2N2O5
Molecular Weight	467.342
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histone-lysine N-methyltransferase EZH2 10 Target ID: Q15910\|\|\|Q96FI6 Gene ID: 2146.0 Gene Symbol: EZH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/29211475	Inhibitor 8504

Substance Class	Chemical Created by `admin` on `Tue Apr 01 23:13:33 GMT 2025` Edited by `admin` on `Tue Apr 01 23:13:33 GMT 2025`
Record UNII	S4L4MM20B6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PF-06821497

Preferred Name

English

Mevrometostat

Official Name

English

MEVROMETOSTAT [USAN]

Common Name

English

1(2H)-Isoquinolinone, 5,8-dichloro-2-[(1,2-dihydro-4-methoxy-6-methyl-2-oxo-3-pyridinyl)methyl]-3,4-dihydro-7-[(R)-methoxy-3-oxetanylmethyl]-

Systematic Name

English

5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoqinolin-1(2H)-one

Systematic Name

English

mevrometostat [INN]

Common Name

English

5,8-dichloro-7-[(R)-methoxy(oxetan-3-yl)methyl]-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one

Systematic Name

English

Code System Code Type Description

INN

13206