Lonpovameran

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:41:40 GMT 2025` Edited by `admin` on `Wed Apr 02 20:41:40 GMT 2025`
Nucleic Acid Type	mRNA VACCINE
Sequence Type	COMPLETE
Record UNII	UY3ACU236M
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Lonpovameran

Official Name

English

mRNA-2319

Preferred Name

English

lonpovameran [INN]

Common Name

English

RNA (recombinant 5?-(m7G-(5??5?)-ppp-Am)-capped Venezuelan equine encephalitis virus nonstructural proteins nsP1, nsP2 [739-leucine], nsP3 [endo-551a-arginine] and nsP4 (RNA-dependent RNA polymerase) codon-optimized transgene plus severe acute respirator

Common Name

English

self-amplifying messenger RNA (mRNA), 5'-capped, encoding codon-optimised Venezuelan equine encephalitis virus (VEEV) RNA-dependent RNA polymerase (VEEV proteins nsP1, nsP2, nsP3 and nsP4) and a full-length codon-optimised pre-fusion stabilised conformat

Common Name

English

Code System Code Type Description

CAS

2972476-18-7

Created by admin on Wed Apr 02 20:41:40 GMT 2025 , Edited by admin on Wed Apr 02 20:41:40 GMT 2025

PRIMARY

NCI_THESAURUS

C211813

Created by admin on Wed Apr 02 20:41:40 GMT 2025 , Edited by admin on Wed Apr 02 20:41:40 GMT 2025

PRIMARY

INN

13556

Created by admin on Wed Apr 02 20:41:40 GMT 2025 , Edited by admin on Wed Apr 02 20:41:40 GMT 2025

PRIMARY

FDA UNII

UY3ACU236M

Created by admin on Wed Apr 02 20:41:40 GMT 2025 , Edited by admin on Wed Apr 02 20:41:40 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_11821	11821 / 11821

Linkage	Site Range	Site Count
Phosphate	1_2-1_11821	11820 / 11820

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TARGET ORGANISM->VACCINE ANTIGEN

Amount:


					CRW4LMD2G5

Lonpovameran expressed preprotein antigen

EXPRESSED PROTEIN->VECTOR

Amount:

Related Record Type Details


					UY3ACU236M

Lonpovameran

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS	A		7M-G-PPP-2'M-A-P MRNA CAP	P7W5ZN6FY2