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Details

Stereochemistry ACHIRAL
Molecular Formula C14H13N3O4S2
Molecular Weight 351.401
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MELOXICAM

SMILES

CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C3=C(C=CC=C3)S1(=O)=O

InChI

InChIKey=ZRVUJXDFFKFLMG-UHFFFAOYSA-N
InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19)

HIDE SMILES / InChI
Molecular Formula C14H13N3O4S2
Molecular Weight 351.401
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:40 UTC 2023
Edited
by admin
on Fri Dec 15 15:52:40 UTC 2023
Record UNII
VG2QF83CGL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MELOXICAM
EP   GREEN BOOK   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD  
INN   USAN  
Official Name English
RECOCAM
Brand Name English
MELOXIDOLOR
Common Name English
Meloxicam [WHO-DD]
Common Name English
COXICAM
Brand Name English
MELOXIVET
Brand Name English
UH-AC-62 XX
Code English
MELOXICAM [HSDB]
Common Name English
VIVLODEX
Brand Name English
meloxicam [INN]
Common Name English
MELOXICAM [ORANGE BOOK]
Common Name English
MELOXORAL
Brand Name English
REVITACAM
Brand Name English
N1539
Code English
FLEXICAM
Brand Name English
MOVATEC
Brand Name English
MELOXICAM [GREEN BOOK]
Common Name English
ZELERIS COMPONENT MELOXICAM
Brand Name English
4-HYDROXY-2-METHYL-N-(5-METHYL-2-THIAZOLYL)-2H-1,2-BENZOTHIAZINE-3-CARBOXAMIDE-1,1-DIOXIDE
Systematic Name English
MELFAX
Brand Name English
UH-AC 62XX
Code English
QMIIZ ODT
Brand Name English
MELOXICAM [MI]
Common Name English
MELOXICAM [MART.]
Common Name English
ANJESO
Brand Name English
N-1539
Code English
MELOXICAM [JAN]
Common Name English
MELOXICAM [EMA EPAR VETERINARY]
Common Name English
ZYNRELEF COMPONENT MELOXICAM
Brand Name English
INFLACAM
Brand Name English
MELOVEM
Brand Name English
METACAM
Brand Name English
MELOXICAM [VANDF]
Common Name English
MELOXICAM [USP-RS]
Common Name English
RHEUMOCAM
Brand Name English
MELOXIDYL
Brand Name English
MELOXICAM COMPONENT OF ZYNRELEF
Brand Name English
MELOXICAM [USAN]
Common Name English
MELOXICAM [USP MONOGRAPH]
Common Name English
MOBIC
Brand Name English
LOXICOM
Common Name English
MELOXICAM [EP MONOGRAPH]
Common Name English
CONTACERA
Brand Name English
MELOXICAM COMPONENT OF ZELERIS
Brand Name English
ACTICAM
Brand Name English
EMDOCAM
Brand Name English
MELOSUS
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C1323
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RECOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDYL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXORAL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RECOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
FDA ORPHAN DRUG 160602
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS INFLACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS METACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS METACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
CFR 21 CFR 520.1367
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS EMDOCAM (AUTHORISED)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDOLOR [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDYL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
WHO-VATC QM01AC56
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
LIVERTOX NBK548278
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDYL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOSUS[AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RHEUMOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOVEM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
NDF-RT N0000175721
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDYL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RHEUMOCAM [AUTHORIZED]
EMA VETERINARY ASSESSMENT REPORTS CONTACERA (AUTHORISED)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS LOXICOM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDOLOR [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXORAL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS METACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS METACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS REVITACAM [WITHDRAWN]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOVEM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS METACAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS FLEXICAM WITHDRAWN)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RECOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
WHO-ATC M01AC06
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
NDF-RT N0000000160
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS LOXICOM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS ZELERIS [AUTHORISED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
WHO-ATC M01AC56
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDOLOR [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS FLEXICAM WITHDRAWN)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS LOXICOM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS LOXICOM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS CONTACERA (AUTHORISED)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
CFR 21 CFR 522.1367
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA ASSESSMENT REPORTS MELOXIDOLOR [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RHEUMOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDYL [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS CONTACERA (AUTHORISED)
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RHEUMOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIVET [WITHDRAWM]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
NDF-RT N0000175722
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS RHEUMOCAM [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA ASSESSMENT REPORTS ACTICAM [AUTHORISED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
WHO-VATC QM01AC06
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
EMA VETERINARY ASSESSMENT REPORTS MELOXIDOLOR [AUTHORIZED]
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
Code System Code Type Description
RXCUI
41493
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID1020803
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
HSDB
7741
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
FDA UNII
VG2QF83CGL
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
DRUG CENTRAL
1676
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
NCI_THESAURUS
C61439
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
MERCK INDEX
m7164
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY Merck Index
MESH
C065757
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
CHEBI
6741
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
CAS
71125-38-7
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
USAN
JJ-71
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
WIKIPEDIA
MELOXICAM
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
LACTMED
Meloxicam
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
INN
5615
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
DAILYMED
VG2QF83CGL
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
PUBCHEM
54677470
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
ChEMBL
CHEMBL599
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
DRUG BANK
DB00814
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
SMS_ID
100000092098
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
IUPHAR
7220
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
RS_ITEM_NUM
1379401
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
EVMPD
SUB08726MIG
Created by admin on Fri Dec 15 15:52:40 UTC 2023 , Edited by admin on Fri Dec 15 15:52:40 UTC 2023
PRIMARY
Related Record Type Details
Structure of MELOXICAM MEGLUMINE MONOHYDRATE
SALT/SOLVATE -> PARENT
Structure of MELOXICAM
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Structure of MELOXICAM
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Related Record Type Details
Structure of 5-HYDROXYMETHYL MELOXICAM
METABOLITE INACTIVE -> PARENT
Structure of 5-CARBOXYMELOXICAM
METABOLITE INACTIVE -> PARENT
Structure of 5-HYDROXYMETHYL MELOXICAM
METABOLITE INACTIVE -> PARENT
Structure of 5-CARBOXYMELOXICAM
METABOLITE INACTIVE -> PARENT
In vitro studies indicate that CYP2C9 plays an important role in this metabolic pathway with a minor contribution of the CYP3A4 isozyme.
IN-VITRO
Related Record Type Details
Structure of 2-AMINO-5-METHYL-THIAZOLE
IMPURITY -> PARENT
Procedure 1 and 2; at 260 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID ETHYLESTER 1,1-DIOXIDE
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.0
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of N-ETHYL MELOXICAM, (Z)-
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of ISOPROPYL-4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
IMPURITY -> PARENT
UNSPECIFIED
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID ETHYLESTER 1,1-DIOXIDE
IMPURITY -> PARENT
Procedure 1; at 350 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of N-ETHYL MELOXICAM, (Z)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of 2-AMINO-5-METHYL-THIAZOLE
IMPURITY -> PARENT
at 260 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of METHYL 4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE 1,1-DIOXIDE
IMPURITY -> PARENT
UNSPECIFIED
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of ISOPROPYL-4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLATE-1,1-DIOXIDE
IMPURITY -> PARENT
Procedure 2; at 350 nm
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of MELOXICAM
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Volume of Distribution PHARMACOKINETIC
ORAL BIOAVAILABILITY PHARMACOKINETIC
Route of Elimination PHARMACOKINETIC RENAL

MAXIMUM TOLERATED DOSE TOXICITY SUSPENSION, TABLET: 15 mg/day

BIOAVAILABILITY PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC RENAL FAILURE: 18 HOURS

HEPATIC INSUFFICIENCY: 16 HOURS

Tmax PHARMACOKINETIC EFFECT OF FOOD: INCREASED BY 3 HOURS (ORAL SOLUMATRIX CAPSULE)

ELDERLY WOMEN: 6 HOURS (15 mg TABLET)

4-8 HOURS (15 mg TABLET)

ELDERLY MEN: 5 HOURS (15 mg TABLET)

RENAL IMPAIRMENT: 2.5-4 HOURS (15 mg TABLET)

8-11 HOURS (30 mg TABLET)

2 HOURS (5 AND 10 mg SOLUMATRIX CAPSULE)

HEPATIC IMPAIRMENT: 10 HOURS (15 mg TABLET)

PROTEIN BINDING PHARMACOKINETIC
NIH
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