Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H31F6N7O2 |
| Molecular Weight | 635.6033 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC(F)(F)C1=CC(=CC(=C1)C(=O)N2CCN(CC3=NNN=C3CN4CCOCC4)C[C@H]2CC5=CNC6=C5C=CC=C6)C(F)(F)F
InChI
InChIKey=SXASYKWUZQHLET-HSZRJFAPSA-N
InChI=1S/C30H31F6N7O2/c31-29(32,33)21-11-19(12-22(14-21)30(34,35)36)28(44)43-6-5-42(16-23(43)13-20-15-37-25-4-2-1-3-24(20)25)18-27-26(38-40-39-27)17-41-7-9-45-10-8-41/h1-4,11-12,14-15,23,37H,5-10,13,16-18H2,(H,38,39,40)/t23-/m1/s1
| Molecular Formula | C30H31F6N7O2 |
| Molecular Weight | 635.6033 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Severe embryopathy and exposure to methimazole in early pregnancy. | 2002-02 |
|
| Cell necrosis and apoptosis are differentially regulated during goitre development and iodine-induced involution. | 2002-02 |
|
| Influence of hypothyroidism on circulating concentrations and liver expression of IGF-binding proteins mRNA from neonatal and adult rats. | 2002-02 |
|
| Clinical features and outcomes in children with antineutrophil cytoplasmic autoantibody-positive glomerulonephritis associated with propylthiouracil treatment. | 2002-02 |
|
| Streptozotocin diabetes protects against arrhythmias in rat isolated hearts: role of hypothyroidism. | 2002-01-25 |
|
| Polarization IR spectra of model crystals containing cyclic N-H...S bonded dimers: 2-mercaptothiazoline and 2-mercapto-1-methylimidazole. | 2002-01-15 |
|
| Subclinical hyperthyroidism. | 2002-01-03 |
|
| Depigmentation of brown Guinea pig skin by topical application of methimazole. | 2002-01 |
|
| Severe and mild neonatal hypothyroidism mediate opposite effects on Leydig cells of rats. | 2002-01 |
|
| Teratogen update: antithyroid drugs-methimazole, carbimazole, and propylthiouracil. | 2002-01 |
|
| Methimazole-induced asthma? | 2002-01 |
|
| Identification of active flavin-containing monooxygenase isoform 2 in human lung and characterization of expressed protein. | 2002-01 |
|
| Impact of hyperthyroidism and its correction on vascular reactivity in humans. | 2001-12-18 |
|
| Protracted expression of serotonin transporter and altered thalamocortical projections in the barrelfield of hypothyroid rats. | 2001-12 |
|
| Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver. | 2001-12 |
|
| Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus. | 2001-11-26 |
|
| Apoptosis, necrosis, and cell proliferation induced by S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cells. | 2001-11-15 |
|
| [Graves-Basedow disease associated with unusual variation of thyroid papillary carcinoma: a clinical case]. | 2001-11-02 |
|
| Methimazole-induced pulmonary hemorrhage associated with antimyeloperoxidase-antineutrophil cytoplasmic antibody: a case report. | 2001-11 |
|
| Hyperemesis gravidarum associated with thyrotoxicosis and a past history of an eating disorder. | 2001-11 |
|
| Influence of nicotinamide on the radiosensitivity of normal and goitrous thyroid in the rat. | 2001-11 |
|
| Adverse effects of prenatal methimazole exposure. | 2001-11 |
|
| Effect of eicosapentaenoic acid ethyl ester on hypothyroid function. | 2001-11 |
|
| Methimazole as an antioxidant and immunomodulator in thyroid cells: mechanisms involving interferon-gamma signaling and H(2)O(2) scavenging. | 2001-11 |
|
| Radioiodine and Graves' ophthalmopathy reconsidered. | 2001-11 |
|
| Different role of insulin in GLUT-1 and -4 regulation in heart and skeletal muscle during perinatal hypothyroidism. | 2001-11 |
|
| The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats. | 2001-10-27 |
|
| Thyroid hormones modify susceptibility to lidocaine-kindling in rats. | 2001-10-19 |
|
| Selective effect of hypothyroidism on expression of myelin markers during development. | 2001-10-15 |
|
| Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to Graves' disease. | 2001-10-11 |
|
| Dermatomyositis and Graves' disease. | 2001-10-03 |
|
| Severe myocardial ischemia following hormone replacement in two cases of hypothyroidism with normal coronary arteriogram. | 2001-10 |
|
| Risk of torsades de pointes from oral erythromycin with concomitant carbimazole (methimazole) administration. | 2001-10 |
|
| Suppression of serum TSH by Graves' Ig: evidence for a functional pituitary TSH receptor. | 2001-10 |
|
| Use of oral cholecystographic agents in the treatment of amiodarone-induced hyperthyroidism. | 2001-10 |
|
| Antithyroid drugs as a factor influencing the outcome of radioiodine therapy in Graves' disease and toxic nodular goitre? | 2001-09 |
|
| Effect of losartan on sodium appetite of hypothyroid rats subjected to water and sodium depletion and water, sodium and food deprivation. | 2001-09 |
|
| Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats. | 2001-09 |
|
| Ca(2+)/nicotinamide adenine dinucleotide phosphate-dependent H(2)O(2) generation is inhibited by iodide in human thyroids. | 2001-09 |
|
| Clinical practice. Subclinical hyperthyroidism. | 2001-08-16 |
|
| [Long-term results of ultrasound-guided ethanol injections in patients with autonomous thyroid nodules and hyperthyroidism]. | 2001-08-15 |
|
| Estimation of antithyroid drug dose in Graves' disease: value of quantification of thyroid blood flow with color duplex sonography. | 2001-08 |
|
| A case of thyrotoxicosis with pancytopenia. | 2001-06 |
|
| [Effect of thyroxine upon prevention of recurrence of Graves' disease treated with antithyroid drugs]. | 2001-03-10 |
|
| Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. | 2001 |
|
| Body, heart, thyroid gland and skeletal muscle weight changes in rats with altered thyroid status. | 2001 |
|
| Drug-induced congenital defects: strategies to reduce the incidence. | 2001 |
|
| Role of thyroid hormones in the maturation and organisation of rat barrel cortex. | 2001 |
|
| [Ablative therapy for immune hyperthyroidism in patients with ophthalmopathy]. | 2001 |
|
| The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:36:18 GMT 2025
by
admin
on
Mon Mar 31 23:36:18 GMT 2025
|
| Record UNII |
WPL66843QN
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
Download
| Name | Type | Language | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-((2R)-2-(1H-INDOL-3-YLMETHYL)-4-((5-(MORPHOLINOMETHYL)-2H-TRIAZOL-4-YL)METHYL)PIPERAZIN-1-YL)METHANONE
Created by
admin on Mon Mar 31 23:36:18 GMT 2025 , Edited by admin on Mon Mar 31 23:36:18 GMT 2025
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11635932
Created by
admin on Mon Mar 31 23:36:18 GMT 2025 , Edited by admin on Mon Mar 31 23:36:18 GMT 2025
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PRIMARY | |||
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WPL66843QN
Created by
admin on Mon Mar 31 23:36:18 GMT 2025 , Edited by admin on Mon Mar 31 23:36:18 GMT 2025
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393101-98-9
Created by
admin on Mon Mar 31 23:36:18 GMT 2025 , Edited by admin on Mon Mar 31 23:36:18 GMT 2025
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INHIBITOR
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
