METHYLPREDNISOLONE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H30O5
Molecular Weight	374.4706
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of METHYLPREDNISOLONE

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](C)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=VHRSUDSXCMQTMA-PJHHCJLFSA-N

InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H30O5
Molecular Weight	374.4706
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:06:46 UTC 2023` Edited by `admin` on `Fri Dec 15 15:06:46 UTC 2023`
Record UNII	X4W7ZR7023
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHYLPREDNISOLONE

Official Name

English

METHYLPREDNISOLONE HYDROGEN SUCCINATE IMPURITY A [EP IMPURITY]

Common Name

English

U-67,590A

Code

English

METHYLPREDNISOLONE [USP MONOGRAPH]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 11,17,21-TRIHYDROXY-6-METHYL-, (6.ALPHA.,11.BETA.)-

Systematic Name

English

METHYLPREDNISOLONE [GREEN BOOK]

Common Name

English

METHYLPREDNISOLONE [EP MONOGRAPH]

Common Name

English

NSC-19987

Code

English

METHYLPREDNISOLONE [MI]

Common Name

English

11β,17,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione

Systematic Name

English

METHYLPREDNISOLONE [MART.]

Common Name

English

6-METHYL-PREDNISOLONE

Common Name

English

METHYLPREDNISOLONE COMPONENT OF NEO-MEDROL

Common Name

English

METHYLPREDNISOLONE [USP-RS]

Common Name

English

METHYLPREDNISOLONE [ORANGE BOOK]

Common Name

English

Methylprednisolone [WHO-DD]

Common Name

English

methylprednisolone [INN]

Common Name

English

NEO-MEDROL COMPONENT METHYLPREDNISOLONE

Common Name

English

METHYLPREDNISOLONE ACETATE IMPURITY B [EP IMPURITY]

Common Name

English

J3.872E

Code

English

METHYLPREDNISOLONE [JAN]

Common Name

English

MEDROL

Brand Name

English

6-METHYLPREDNISOLONE

Common Name

English

METHYLPREDNISOLONE [VANDF]

Common Name

English

METHYLPREDNISOLONE [HSDB]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QH02AB04

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

FDA ORPHAN DRUG

531816

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

S01CA08

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

CFR

21 CFR 520.1408

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

D07AA01

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

CFR

21 CFR 520.1409

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-VATC

QD07CA02

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

NCI_THESAURUS

C521

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-VATC

QH02BX01

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

CFR

21 CFR 522.1410

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

NDF-RT

N0000175576

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

H02BX01

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-VATC

QS01CA08

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

D07CA02

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

D07AC14

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-VATC

QD10AA02

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-VATC

QD07AA01

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

8.3

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

H02AB04

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

NDF-RT

N0000175450

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

WHO-ATC

D10AA02

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

LIVERTOX

626

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

Code System Code Type Description

DRUG CENTRAL

1768

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

MESH

D008775

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

NCI_THESAURUS

C647

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

DRUG BANK

DB00959

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

SMS_ID

100000091803

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

HSDB

3127

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

CAS

83-43-2

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

INN

732

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

PUBCHEM

6741

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

IUPHAR

7088

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

EPA CompTox

DTXSID7023300

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

RXCUI

6902

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

RxNorm

NSC

19987

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

EVMPD

SUB08872MIG

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

LACTMED

Methylprednisolone

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

FDA UNII

X4W7ZR7023

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

ECHA (EC/EINECS)

201-476-4

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

CHEBI

6888

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

ChEMBL

CHEMBL650

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

DAILYMED

X4W7ZR7023

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

WIKIPEDIA

METHYLPREDNISOLONE

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

RS_ITEM_NUM

1435003

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

CHEBI

135864

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

MERCK INDEX

m7454

Created by admin on Fri Dec 15 15:06:46 UTC 2023 , Edited by admin on Fri Dec 15 15:06:46 UTC 2023

PRIMARY

Merck Index

Related Record Type Details


					22ES734693

MULTIDRUG RESISTANCE PROTEIN 1

TRANSPORTER -> SUBSTRATE

Related Record Type Details


					S86E58B4X9

20-HYDROXY METHYLPREDNISOLONE, (20R)-

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE


					621XR2W6OP

6.ALPHA.-METHYLPREDNISONE

METABOLITE -> PARENT


					595B86Q648

6,7-DIDEHYDRO-20-HYDROXY-6-METHYLPREDNISOLONE, (20R)-

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE


					2DVV21959V

17-DEOXY-20-HYDROXY METHYLPREDNISOLONE

METABOLITE -> PARENT


					K0VHF4KL3N

20-HYDROXY METHYLPREDNISOLONE, (20S)-

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE


					4IL21793D6

11-DEOXY-20-HYDROXY METHYLPREDNISOLONE

METABOLITE -> PARENT


					7S5HEH87YT

6,7-DIDEHYDRO-11-KETO METHYLPREDNISOLONE

METABOLITE -> PARENT

Qualification:

URINE


					FUK6L134YQ

6,7-DIDEHYDRO-20-HYDROXY-6-METHYLPREDNISOLONE, (20S)-

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE


					DTF921KH1Z

6,7-DIDEHYDRO METHYLPREDNISOLONE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Related Record Type Details


					D6B7O7187C

(6.ALPHA.,11.BETA.,20S)-11,17,20-TRIHYDROXY-6-METHYL-3-OXOPREGNA-1,4-DIEN-21-OIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					UP4NO9901H

11.BETA.-HYDROXY-6.ALPHA.-METHYLANDROSTA-1,4-DIENE-3,17-DIONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					5GMR90S4KN

METHYLPREDNISOLONE HEMISUCCINATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					43502P7F0P

METHYLPREDNISOLONE ACETATE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					621XR2W6OP

6.ALPHA.-METHYLPREDNISONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					7D6KJ7YT6X

11.BETA.,20-DIHYDROXY-6-METHYLPREGNA-1,4,17(20)-TRIENE-3,21-DIONE

IMPURITY -> PARENT

Amount:


					9PHQ9Y1OLM

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					43502P7F0P

METHYLPREDNISOLONE ACETATE

PARENT -> IMPURITY

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					I3082IBD9A

11.BETA.-HYDROXY-6.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIENE-17.BETA.-CARBOXYLIC ACID

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					31G2E0J8OF

17,21-DIHYDROXY-6.ALPHA.-METHYLPREGNA-1,4,9(11)-TRIENE-3,20-DIONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					7XQ6AER9QE

6.ALPHA.-METHYLHYDROCORTISONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					VLK4VG0YDQ

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:


					2RLH33V7DG

11.BETA.,17,21-TRIHYDROXY-6.BETA.-METHYLPREGNA-1,4-DIENE-3,20-DIONE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

EP

Amount:

Related Record Type Details


					X4W7ZR7023

METHYLPREDNISOLONE

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC