TRASTUZUMAB DUOCARMAZINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:28:58 GMT 2025` Edited by `admin` on `Wed Apr 02 08:28:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	XCR2BZ80N7
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

TRASTUZUMAB DUOCARMAZINE

Official Name

English

SYD-985

Preferred Name

English

TRASTUZUMAB DUOCARMAZINE [USAN]

Common Name

English

trastuzumab duocarmazine [INN]

Common Name

English

SYD985

Code

English

Trastuzumab duocarmazine [WHO-DD]

Common Name

English

IMMUNOGLOBULIN G1, ANTI-(HUMAN NEU (RECEPTOR)) (HUMAN-MUS MUSCULUS MONOCLONAL SYD977 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL SYD977 LIGHT CHAIN, DIMER, THIOETHER WITH N-((2-(2-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDINYL)ETHOXY)ETHOXY)CARBO

Systematic Name

English

IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS ERBB2 (EPIDERMAL GROWTH FACTOR RECEPTOR 2, RECEPTOR TYROSINEPROTEIN KINASE ERBB-2, EGFR2, HER2, HER-2, P185CERBB2, NEU, CD340)), HUMANIZED MONOCLONAL ANTIBODY CONJUGATED TO THE PRO-DRUG SECO-DUOCARMYCINHYDROXYB

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C129823

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

NCI_THESAURUS

C1512

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

Code System Code Type Description

USAN

FG-131

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

INN

10273

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

SMS_ID

100000174461

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

NCI_THESAURUS

C118674

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

FDA UNII

XCR2BZ80N7

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

CAS

1642152-40-6

Created by admin on Wed Apr 02 08:28:58 GMT 2025 , Edited by admin on Wed Apr 02 08:28:58 GMT 2025

PRIMARY

From	To
1_22	1_96
1_147	1_203
1_264	1_324
1_370	1_428
2_22	2_96
2_147	2_203
2_264	2_324
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
2_223	4_214
1_229	2_229
1_232	2_232

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					XCR2BZ80N7

TRASTUZUMAB DUOCARMAZINE

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6
AMINO ACID SUBSTITUTION	[1_223] [1_229] [1_232] [2_223] [2_229] [2_232] [3_214] [4_214]			Amount:	SECO-DUBA-LINKER-CYS	UWX7VBI64S

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL