U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

2024
711
Substance Class Protein
Created
by admin
on Tue Apr 01 20:55:30 GMT 2025
Edited
by admin
on Tue Apr 01 20:55:30 GMT 2025
Protein Type BISPECIFIC ANTIBODY
Protein Sub Type IGG1
Sequence Origin HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
Z20OC92TDI
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
Zanidatamab
USAN   INN  
Official Name English
ZW-25
Preferred Name English
Immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (epidermal growth factor receptor 2, receptor tyrosine protein kinase erbB-2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, biparatopic (targeting two different non-overlap
Systematic Name English
Zanidatamab [WHO-DD]
Common Name English
ANTI-HER2 BI-SPECIFIC MONOCLONAL ANTIBODY ZW25
Common Name English
ZANIDATAMAB [USAN]
Common Name English
zanidatamab [INN]
Common Name English
Immunoglobulin G1, anti-(human tyrosine kinase receptor HER2) (human-Mus musculus biparatopic monoclonal ZW25 light chain variable region fragment) fusion protein with peptide (synthetic 20-amino acid linker) fusion protein with human-Mus musculus bipara
Systematic Name English
ZW25
Code English
JZP598
Code English
Classification Tree Code System Code
NCI_THESAURUS C155711
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
NCI_THESAURUS C28227
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
FDA ORPHAN DRUG 715119
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
FDA ORPHAN DRUG 554716
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
FDA ORPHAN DRUG 519516
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
Code System Code Type Description
USAN
MN-268
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
FDA UNII
Z20OC92TDI
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
DRUG BANK
DB15471
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
NCI_THESAURUS
C130010
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
SMS_ID
300000009722
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
INN
10997
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
CAS
2169946-15-8
Created by admin on Tue Apr 01 20:55:30 GMT 2025 , Edited by admin on Tue Apr 01 20:55:30 GMT 2025
PRIMARY
From To
1_24 1_89
1_150 1_224
1_261 2_229
1_264 2_232
1_296 1_356
1_402 1_460
2_23 2_97
2_147 2_203
2_223 3_215
2_264 2_324
2_370 2_428
3_24 3_89
3_135 3_195
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_332
N 2_300
Related Record Type Details
Zanidatamab-HRII
SUB_CONCEPT->SUBSTANCE
ZANIDATAMAB ZOVODOTIN
CONJUGATE -> PARENT
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2
TARGET -> INHIBITOR
BINDING
Related Record Type Details
Zanidatamab
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
NCATS
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DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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