ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-BENZOATE 17-BUTANOATE

First approved in 1940

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H34O4
Molecular Weight	446.5779
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-BENZOATE 17-BUTANOATE

Structure Search

SMILES

CCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(OC(=O)C5=CC=CC=C5)=CC=C4[C@H]3CC[C@]12C

InChI

InChIKey=MKYFGNOOEKZNPW-ZRJUGLEFSA-N

InChI=1S/C29H34O4/c1-3-7-27(30)33-26-15-14-25-24-12-10-20-18-21(32-28(31)19-8-5-4-6-9-19)11-13-22(20)23(24)16-17-29(25,26)2/h4-6,8-9,11,13,18,23-26H,3,7,10,12,14-17H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C29H34O4
Molecular Weight	446.5779
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11250930http://www.drugbank.ca/drugs/DB00783https://pubchem.ncbi.nlm.nih.gov/compound/222757
Curator's Comment: description was created based on several sources, including https://books.google.ru/books?id=68n6f1Nw6EEC&pg=PA64&redir_esc=y#v=onepage&q&f=false | https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/ucm116143.pdf | https://www.fda.gov/downloads/AnimalVeterinary/Products/ApprovedAnimalDrugProducts/FOIADrugSummaries/UCM338208.pdf

Estradiol benzoate is the synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. Although estradiol benzoate is not approved by the FDA for use in humans in the United States, it is approved for veterinary use as a subdermal implant both alone (CELERIN®) and in combination with the anabolic steroid trenbolone acetate (SYNOVEX® Plus).

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Steryl-sulfatase 33 Target ID: P08842 Gene ID: 412.0 Gene Symbol: STS Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/11250930	Substrate 661
Estrogen receptor alpha 134 Target ID: CHEMBL206 Sources: http://www.drugbank.ca/drugs/DB00783	Agonist 2752	0.0084 nM [EC50]
Estrogen receptor beta 113 Target ID: CHEMBL242 Sources: http://www.drugbank.ca/drugs/DB00783	Agonist 2752	1.4 nM [EC50]
Androgen Receptor 169 Target ID: CHEMBL1871 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16309907	Antagonist 2849	19.1 nM [IC50]
Estrogen receptor alpha 134 Target ID: CHEMBL206 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/222757	Agonist 2752	0.13 nM [Ki]
Estrogen receptor beta 113 Target ID: CHEMBL242 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/222757	Agonist 2752	0.09 nM [Kd]

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2596
Vaginal atrophy 27 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020375s027lbl.pdf	Primary	Approved 8583	CLIMARA Approved Use Climara is an estrogen indicated for: •Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause •Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause •Treatment of Hypoestrogenism due to Hypogonadism, Castration or Primary Ovarian Failure •Prevention of Postmenopausal Osteoporosis Launch Date 1974
Postmenopausal osteoporosis 59 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020375s027lbl.pdf	Preventing	Approved 8583	CLIMARA Approved Use Climara is an estrogen indicated for: •Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause •Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause •Treatment of Hypoestrogenism due to Hypogonadism, Castration or Primary Ovarian Failure •Prevention of Postmenopausal Osteoporosis Launch Date 1974
Primary ovarian failure 27 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/020375s027lbl.pdf	Primary	Approved 8583	CLIMARA Approved Use Climara is an estrogen indicated for: •Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause •Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause •Treatment of Hypoestrogenism due to Hypogonadism, Castration or Primary Ovarian Failure •Prevention of Postmenopausal Osteoporosis Launch Date 1974
Unknown 2596

C_max

Value	Dose	Co-administered	Analyte	Population
92 pg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020655s020lbl.pdf	0.05 mg 1 times / day multiple, topical dose: 0.05 mg route of administration: Topical experiment type: MULTIPLE co-administered:		ESTRADIOL serum	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN
14.7 pg/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022038s005s006lbl.pdf	0.25 mg 1 times / day steady-state, topical dose: 0.25 mg route of administration: Topical experiment type: STEADY-STATE co-administered:		ESTRADIOL serum	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

AUC

Value	Dose	Co-administered	Analyte	Population
236 pg × h/mL DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022038s005s006lbl.pdf	0.25 mg 1 times / day steady-state, topical dose: 0.25 mg route of administration: Topical experiment type: STEADY-STATE co-administered:		ESTRADIOL serum	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.75 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020655s020lbl.pdf	0.05 mg 1 times / day multiple, topical dose: 0.05 mg route of administration: Topical experiment type: MULTIPLE co-administered:		ESTRADIOL serum	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN
10 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022038s005s006lbl.pdf	0.25 mg 1 times / day steady-state, topical dose: 0.25 mg route of administration: Topical experiment type: STEADY-STATE co-administered:		ESTRADIOL serum	Homo sapiens population: UNKNOWN age: ADULT sex: FEMALE food status: UNKNOWN

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1946	substrate 1193	substrate 1388

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	CYP1B1 104 CYP1A1 389 CYP1A2 1197 CYP3A5 446 CYP3A7 109 CYP2C18 149 CYP2E1 729 CYP2A6 626 CYP2B6 776 CYP2C8 810 CYP2C19 1119 UGT1A1 479 UGT1A3 470 UGT1A4 399 UGT1A5 56 UGT1A6 343 UGT1A7 249 UGT1A8 323 UGT1A9 423 UGT1A10 331 UGT2A2 49 UGT2A3 49 UGT2B4 278 UGT2B7 456 UGT2B10 131 UGT2B17 237 UGT2B28 65	CYP2B6 669

Drug as perpetrator

Target	Modality	Activity	Metabolite	Clinical evidence
CYP2B6 1160	inducer 1966 Sources: https://www.sciencedirect.com/science/article/pii/S0006295212002328 Page: -	yes
P-gp 1932	supressor 160 Sources: https://pubs.acs.org/doi/abs/10.1021/mp900077q Page: -	yes

Drug as victim

Target	Modality	Activity
CYP2A6 626	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2B6 776	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2C19 1119	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2C8 810	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2C9 1193	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2D6 1388	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	minor
CYP2C18 149	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	no
CYP2E1 729	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	no
UGT1A5 56	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT1A6 343	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT1A7 249	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT1A9 423	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT2B10 131	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT2B28 65	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT2B4 278	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	no
UGT1A1 479	substrate 4014 Sources: https://dmd.aspetjournals.org/content/30/11/1266.short Page: -	yes [Km 7 uM]
CYP1A1 389	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	yes
CYP1A2 1197	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	yes
CYP1B1 104	substrate 4014 Sources: https://www.pnas.org/content/93/18/9776.short Page: -	yes
CYP3A4 1946	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	yes
CYP3A5 446	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	yes
CYP3A7 109	substrate 4014 Sources: https://academic.oup.com/endo/article/146/7/2911/2499912 Page: -	yes
UGT1A10 331	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT1A3 470	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT1A4 399	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT1A8 323	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT2A2 49	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT2A3 49	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT2B17 237	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes
UGT2B7 456	substrate 4014 Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234363/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
Aaron Chemicals	AR0035II	http://www.aaronchem.com/50-28-2
AbMole Bioscience	M5625	http://www.abmole.com/products/estradiol.html
Achemtek	0104-010473	http://www.achemtek.com/50-28-2
Acorn PharmaTech	ACN-032013	http://www.acornpharmatech.com/
Acros Organics	AC436320050	https://www.fishersci.com/shop/products/estradiol-98-acros-organics/AC436320050
Acros Organics	AC436320250	https://www.fishersci.com/shop/products/estradiol-98-acros-organics-1/AC436320250
AEchem Scientific Corp., USA	AE046017	http://www.aechemsc.com/info_products/AE046017.php
AHH Chemical co.,ltd	API-1858	http://www.ahhchemical.com/product/API-1858.html
AHH Chemical co.,ltd	NP-1226	http://www.ahhchemical.com/product/NP-1226.html
AK Scientific, Inc. (AKSCI)	H061	http://www.aksci.com/item_detail.php?cat=H061
AK Scientific, Inc. (AKSCI)	J10189	http://www.aksci.com/item_detail.php?cat=J10189
Alfa Aesar	L03801	https://www.alfa.com/en/catalog/L03801/
Alsachim	1651	http://www.alsachim.com/product-C2920-glo.bal-view.html
ApexBio Technology	A8425	http://www.apexbt.com/estradiol-22654.html
Aurora Fine Chemicals LLC	A13.142.520	http://online.aurorafinechemicals.com/info?ID=A13.142.520
Aurum Pharmatech LLC	Z-4415	http://www.Aurumpharmatech.com/Product/ProductDetails/Z_4415
AvaChem Scientific	4548	http://www.avachem.com/productSearch.asp?4548
Avantor Inc	101094-946	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101094-946
BioChemPartner	BCP08579	http://www.biochempartner.com/50-28-2-BCP08579
BioSynth	Q-201503	https://www.biosynth.com/en/products/life-science/other-biochemicals/products/Q-201503.html
Boerchem	BC200811	http://www.boerchem.com/?product_33552.html
Calbiochem	3301	http://www.emdbiosciences.com/product/3301
Chem Scene	CS-1938	http://www.chemscene.com/50-28-2.html
Chemenu	CM110581	http://www.chemenu.com/products/CM110581
ChemFaces	CFN90035	http://www.chemfaces.com/natural/Estradiol-CFN90035.html
ChemMol	1203050	http://www.chemmol.com/chemmol/1203050.html
ChemMol	2101440	http://www.chemmol.com/chemmol/2101440.html
ChemMol	2101445	http://www.chemmol.com/chemmol/2101445.html
ChemMol	30100431	http://www.chemmol.com/chemmol/30100431.html
ChemMol	44000538	http://www.chemmol.com/chemmol/44000538.html
Chemspace	CSSB00000693940	https://chem-space.com/CSSB00000693940
Clearsynth	CS-O-11584	https://www.clearsynth.com/en/CSO11584.html
DC Chemicals	DCAPI1200	http://www.dcchemicals.com//product_show-Estradiol.html
EMD Millipore	3301	http://www.emdbiosciences.com/product/3301
Enamine	Z1847670481	https://www.enaminestore.com/catalog/Z1847670481
eNovation Chemicals	D382843	http://www.enovationchem.com/productDetails.asp?productID=D382843
eNovation Chemicals	D961664	https://www.enovationchem.com/ProductDetails.asp?ProductID=D961664
Glentham Life Sciences	GP9683	http://www.glentham.com/products/product/GP9683/
iChemical	EBD2157872	http://www.ichemical.com/products/50-28-2.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00235694	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00235694
LGC Standards	DRE-C13213100	https://www.lgcstandards.com/US/en/p/DRE-C13213100
LGC Standards	DRE-XA13213100AL	https://www.lgcstandards.com/US/en/p/DRE-XA13213100AL
Matrix Scientific	194601	https://www.matrixscientific.com/194601.html
MedChem Express	HY-B0141	https://www.medchemexpress.com/Estradiol.html
MuseChem	I013886	https://www.musechem.com/product/I013886.html
MuseChem	M131188	https://www.musechem.com/product/M131188.html
OChem	2711	http://www.ocheminc.com/index.php?act=psearch&pid=003E693
Parchem	18436	http://www.parchem.com/chemical-supplier-distributor/Estradiol-complex-008436.aspx
Sigma-Aldrich	1250008_USP	https://www.sigmaaldrich.com/catalog/product/usp/1250008?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	E-060_CERILLIAN	https://www.sigmaaldrich.com/catalog/product/cerillian/e060?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	E1024_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/e1024?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	E1132_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/e1132?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	E125_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/e125?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S772629	https://www.smolecule.com/products/s772629
THE BioTek	bt-267766	https://www.thebiotek.com/product/inhibitors/bt-267766
Tocris	2824	https://www.tocris.com/products/b-estradiol_2824
VladaChem	VL268274-1G	https://www.vladachem.com/product.php?products=50-28-2
Yuhao Chemical	LT1224	http://www.chemyuhao.com/50-28-2.html

PubMed

Title	Date	PubMed
Complex actions of estradiol-3-sulfate in late gestation fetal brain.	2011-07	21273638
Sulfonation of 17beta-estradiol and inhibition of sulfotransferase activity by polychlorobiphenylols and celecoxib in channel catfish, Ictalurus punctatus.	2007-03-10	17239972
Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer.	2001-04-06	11063747
Constitutive expression of the steroid sulfatase gene supports the growth of MCF-7 human breast cancer cells in vitro and in vivo.	2001-04	11250930
Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation.	2001-03-23	11121427
Enhanced multispecificity of arabidopsis vacuolar multidrug resistance-associated protein-type ATP-binding cassette transporter, AtMRP2.	2001-03-23	11115509
Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1.	2001-03-02	11102445
Unique protein determinants of the subtype-selective ligand responses of the estrogen receptors (ERalpha and ERbeta ) at AP-1 sites.	2001-02-09	11060287
Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells.	2001-02-02	11044445
Vitellogenin-induced pathology in male summer flounder (Paralichthys dentatus).	2001-02	11090901
Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results.	2001-02	11087962
Affinity labeling of rat glutathione S-transferase isozyme 1-1 by 17beta -iodoacetoxy-estradiol-3-sulfate.	2001-01-19	11031273
Effects of heterocyclic amines with mammary gland carcinogenic potential on estrogenic response of uterus in ovariectomized rats.	2001-01-10	11121860
Reduction of gamma-aminobutyric acid-ergic neurotransmission as a putative mechanism of radiation induced activation of the gonadotropin releasing-hormone-pulse generator leading to precocious puberty in female rats.	2001-01-05	11114481
Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum.	2001-01-05	11035025
Acquisition of Lubrol insolubility, a common step for growth hormone and prolactin in the secretory pathway of neuroendocrine cells.	2001-01-05	11024038
In vivo regulation of syndecan-3 expression in the rat uterus by 17 beta-estradiol.	2001-01-05	11024013
Effects of follicle-stimulating hormone with and without luteinizing hormone on serum hormone concentrations, follicle growth, and intrafollicular estradiol and aromatase activity in gonadotropin-releasing hormone-immunized heifers.	2001-01	11133695
Female steroid hormones modulate receptors for nerve growth factor in rat dorsal root ganglia.	2001-01	11133691
Regulation and role of vascular endothelial growth factor in the corpus luteum during mid-pregnancy in rats.	2001-01	11133689
Increased expression of a novel heat shock protein transcript in the mouse uterus during decidualization and in response to progesterone.	2001-01	11133685
Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse.	2001-01	11133684
Pregnancy stimulates secretion of adrenocorticotropin and nitric oxide from peripheral bovine lymphocytes.	2001-01	11133680
Follicle selection in cattle: role of luteinizing hormone.	2001-01	11133675
Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats.	2001-01	11133670
Changes in follicle-stimulating hormone and follicle populations during the ovarian cycle of the common marmoset.	2001-01	11133667
Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression.	2001-01	11133498
Comparison of histological compositions and apoptosis in canine spontaneous benign prostatic hyperplasia treated with androgen suppressive agents chlormadinone acetate and finasteride.	2001-01	11125427
Metabolism of estradiol, ethynylestradiol, and moxestrol in rat uterus, vagina, and aorta: influence of sex steroid treatment.	2001-01	11124233
Sex steroid hormones enhance immune function in male and female Siberian hamsters.	2001-01	11124153
Rapid and reversible inhibition of brain aromatase activity.	2001-01	11123516
Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback.	2001-01	11123512
Stimulatory effect of clofibrate and gemfibrozil administration on the formation of fatty acid esters of estradiol by rat liver microsomes.	2001-01	11123380
Influence of gender and sex hormones on nicotine acute pharmacological effects in mice.	2001-01	11123373
Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart.	2001-01	11123263
Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle.	2001-01	11121374
Dose-response relationships and pharmacokinetics of vitellogenin in rainbow trout after intravascular administration of 17alpha-ethynylestradiol.	2001-01	11090892
Evaluation of an EIA method for measuring serum levels of the estrogen metabolite 2-hydroxyestrone in adults.	2001-01	11090660
Estradiol levels in psychotic disorders.	2001-01	11070332
Neuroprotection by estradiol.	2001-01	11040417
Indole-3-carbinol is a negative regulator of estrogen receptor-alpha signaling in human tumor cells.	2000-12	11110848
Estradiol enhances the resistance of LDL to oxidation by stabilizing apoB-100 conformation.	2000-11-14	11076531
Female sex steroids: effects upon microglial cell activation.	2000-11-01	11063824
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene.	2000-11	11075820
Repression of chick multidrug resistance-associated protein 1 (chMRP1) gene expression by estrogen.	2000-10-31	11080590
Relative binding affinity does not predict biological response to xenoestrogens in rat endometrial adenocarcinoma cells.	2000-10	11086226
Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.	2000-10	11014220
NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1.	2000-09	11074351
[The effect of adrenaline and 17beta-estradiol sulfate on transmembrane potentials of guinea pig cardiomyocytes].	1996-12	9280454
Sulfation of estrone and 17 beta-estradiol in human liver. Catalysis by thermostable phenol sulfotransferase and by dehydroepiandrosterone sulfotransferase.	1992-05-01	1355717

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Estradiol-3-sulfate (E2SO4) infused intracerebroventricularly (icv) significantly increased plasma adrenocorticotropic hormone (ACTH) and cortisol concentrations. All minipumps in the treated fetuses were filled with E2SO4 in the vehicle (water) and minipumps in the control fetuses were filled with vehicle only. These minipumps deliver a constant infusion of 5 μL/h; the concentration of E2SO4 in infusates was therefore 8.33 μg/μL. It was concluded, that E2SO4 had complex actions on the fetal brain, which might involve deconjugation by steroid sulfatase. But that the net result of direct E2SO4 icv infusion was more complex than could be accounted for by infusion of E2 alone.

Substance Class	Chemical Created by `admin` on `Wed Apr 02 06:26:27 GMT 2025` Edited by `admin` on `Wed Apr 02 06:26:27 GMT 2025`
Record UNII	ZE4IGI4UMH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BETA-ESTRADIOL 3-BENZOATE 17-N-BUTYRATE

Preferred Name

English

ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-BENZOATE 17-BUTANOATE

Systematic Name

English

ESTRADIOL BENZOATE BUTYRATE

Common Name

English

ESTRADIOL-3-BENZOATE-17-BUTYRATE

Common Name

English

Code System Code Type Description

WIKIPEDIA

Estradiol_benzoate_butyrate