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Details

Stereochemistry ABSOLUTE
Molecular Formula C18H24O2
Molecular Weight 272.382
Optical Activity ( + )
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESTRADIOL

SMILES

[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]3([H])C4=C(CC[C@@]23[H])C=C(O)C=C4

InChI

InChIKey=VOXZDWNPVJITMN-ZBRFXRBCSA-N
InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

HIDE SMILES / InChI
Molecular Formula C18H24O2
Molecular Weight 272.382
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:14:36 UTC 2023
Edited
by admin
on Fri Dec 15 15:14:36 UTC 2023
Record UNII
4TI98Z838E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ESTRADIOL
GREEN BOOK   HSDB   INCI   INN   JAN   MI   ORANGE BOOK   USP   VANDF   WHO-DD  
INN   INCI  
Official Name English
VAGIFEM
Brand Name English
ESTRADIOL IMPURITY A [IP]
Common Name English
WC3011
Code English
ESTRADIOL [VANDF]
Common Name English
INNOFEM
Brand Name English
ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-
Common Name English
17-.BETA.-OESTRADIOL
Common Name English
ETHINYLESTRADIOL IMPURITY D [EP IMPURITY]
Common Name English
DIVIGEL
Brand Name English
ESTRADIOL [ORANGE BOOK]
Common Name English
17BETA-ESTRADIOL
Common Name English
ESTRADIOL COMPONENT OF COMBIPATCH
Common Name English
FEMPATCH
Brand Name English
ESTRADIOL COMPONENT OF CLIMARA PRO
Common Name English
ESTRADIOL [USP MONOGRAPH]
Common Name English
ESTRADIOL [GREEN BOOK]
Common Name English
OESTRADIOL
Common Name English
IMVEXXY
Brand Name English
ESTRADIOL [JAN]
Common Name English
ELESTRIM
Brand Name English
CLIMARA
Brand Name English
NSC-20293
Code English
ALORA
Brand Name English
ORIAHNN COMPONENT ESTRADIOL
Brand Name English
13.BETA.-METHYL-1,3,5(10)-GONATRIENE-3,17.BETA.-OL
Systematic Name English
ESTRADIOL COMPONENT OF BIJUVA
Common Name English
E2
Common Name English
estradiol [INN]
Common Name English
ESCLIM
Brand Name English
ESTRING
Brand Name English
EVAMIST
Brand Name English
ESTRACE
Brand Name English
PREFEST COMPONENT ESTRADIOL
Common Name English
COMBIPATCH COMPONENT ESTRADIOL
Common Name English
ESTRADIOL COMPONENT OF ANGELIQ
Common Name English
ESTRADIOL VALERATE IMPURITY A [EP IMPURITY]
Common Name English
BIJUVA COMPONENT ESTRADIOL
Common Name English
ESTROGEL
Brand Name English
NSC-9895
Code English
WC-3011
Code English
ESTRADIOL [HSDB]
Common Name English
ESTRADIOL VALERATE METABOLITE E2
Common Name English
MENOSTAR
Brand Name English
ESTRADIOL COMPONENT OF ACTIVELLA
Common Name English
ESTRADIOL ANHYDROUS
Common Name English
17.BETA.-ESTRADIOL
Common Name English
ESTRADERM
Brand Name English
3,17.BETA.-DIHYDROXYESTRA-1,3,5(10)-TRIENE
Systematic Name English
GYNODIOL
Brand Name English
ESTRADIOL 17-BETA
VANDF  
Common Name English
ESTRADIOL 17-BETA [VANDF]
Common Name English
ESTRADIOL [MI]
Common Name English
ESTRADIOL [INCI]
Common Name English
CLIMARA PRO COMPONENT ESTRADIOL
Common Name English
(+)-3,17.BETA.-ESTRADIOL
Systematic Name English
Estra-1,3,5(10)-triene-3,17β-diol
Systematic Name English
ESTRADIOL BENZOATE IMPURITY A [EP IMPURITY]
Common Name English
VIVELLE
Brand Name English
Estradiol [WHO-DD]
Common Name English
ESTRADIOL COMPONENT OF ORIAHNN
Brand Name English
17-BETA-OESTRADIOL
Common Name English
ANGELIQ COMPONENT ESTRADIOL
Common Name English
ESTRADIOL [USP-RS]
Common Name English
ACTIVELLA COMPONENT ESTRADIOL
Common Name English
ESTRADIOL COMPONENT OF PREFEST
Common Name English
Classification Tree Code System Code
LOINC 35384-7
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 34290-7
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 34286-5
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LOINC 12595-5
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LOINC 2239-2
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-ATC G03CA03
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-VATC QG03CA03
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 522.840
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 83097-6
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LOINC 2240-0
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LOINC 14715-7
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LOINC 15062-3
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LOINC 12214-3
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LOINC 34288-1
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
FDA ORPHAN DRUG 231706
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-VATC QG03CA53
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 25401-1
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 310.527
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-VATC QG03AB08
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
NDF-RT N0000011402
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-ATC G03AA14
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 13883-4
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LOINC 2246-7
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WHO-VATC QG03AA14
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 556.240
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 72873-3
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LOINC 34287-3
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LOINC 55857-7
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LOINC 35207-0
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 21263-9
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LIVERTOX 372
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 2243-4
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LOINC 2245-9
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LOINC 2238-4
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LOINC 31176-1
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-ATC G03CA53
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
WHO-ATC G03AB08
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 14960-9
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 2241-8
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
EMA ASSESSMENT REPORTS IOA (WITHDRAWN: CONTRACEPTION)
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
NDF-RT N0000000100
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 12213-5
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 34291-5
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 522.2477
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
NDF-RT N0000175825
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 44730-0
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 34289-9
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 862.1430
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
CFR 21 CFR 862.1260
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
NCI_THESAURUS C2293
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 13736-4
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 55858-5
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LOINC 83096-8
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 2242-6
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
LOINC 2244-2
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Code System Code Type Description
IUPHAR
1013
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-023-8
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
WIKIPEDIA
ESTRADIOL
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
LACTMED
Estradiol
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
DRUG BANK
DB00783
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
EVMPD
SUB96040
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
CHEBI
23965
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
MERCK INDEX
m5028
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY Merck Index
WIKIPEDIA
Estradiol (medication)
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
MESH
D004958
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
NSC
20293
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
EPA CompTox
DTXSID0020573
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
INN
406
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
NCI_THESAURUS
C478
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
ChEMBL
CHEMBL135
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
DRUG CENTRAL
1057
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
CAS
50-28-2
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
SMS_ID
100000091739
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
NSC
9895
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
DAILYMED
4TI98Z838E
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
CHEBI
16469
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
RS_ITEM_NUM
1250008
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
EVMPD
SUB07242MIG
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
FDA UNII
4TI98Z838E
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
RXCUI
4083
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY RxNorm
EVMPD
SUB21195
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
HSDB
3589
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
PUBCHEM
5757
Created by admin on Fri Dec 15 15:14:37 UTC 2023 , Edited by admin on Fri Dec 15 15:14:37 UTC 2023
PRIMARY
Related Record Type Details
Structure of SODIUM ESTRADIOL
SALT/SOLVATE -> PARENT
ALBUMIN HUMAN
BINDER->LIGAND
BINDING
Structure of ESTRADIOL HEMIHYDRATE
SALT/SOLVATE -> PARENT
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A3
METABOLIC ENZYME -> SUBSTRATE
GLUCOCORTICOID RECEPTOR
TARGET -> INHIBITOR
BINDING
IC50
Structure of ESTRADIOL HEMIHYDRATE
SOLVATE->ANHYDROUS
ALDEHYDE OXIDASE
METABOLIC ENZYME -> INHIBITOR
IC50
Structure of ESTRADIOL
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
OATP1B1
TRANSPORTER -> INHIBITOR
ANDROGEN RECEPTOR
TARGET -> AGONIST
BINDING
IC50
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A1
METABOLIC ENZYME -> SUBSTRATE
Structure of ESTRADIOL HEMIHYDRATE
SUBSTANCE->BASIS OF STRENGTH
SEX HORMONE-BINDING GLOBULIN
BINDER->LIGAND
BINDING
ESTROGEN RECEPTOR
TARGET -> AGONIST
Binding Assay
IC50
Related Record Type Details
Structure of ESTRA-1,3,5(10)-TRIENE-3,17-DIOL (17.BETA.)-, 3-BENZOATE 17-BUTANOATE
PRODRUG -> METABOLITE ACTIVE
Structure of ESTRONE SULFATE
METABOLITE -> PARENT
E2 is then extensively metabolized to estrone (E1) (15%), estrone sulfate (E1S) (65%), and other compounds.
Structure of 17.BETA.-ESTRADIOL SULFATE
METABOLITE -> PARENT
Structure of Estradiol distearate
PRODRUG -> METABOLITE ACTIVE
Structure of ESTRADIOL VALERATE
PRODRUG -> METABOLITE ACTIVE
Structure of 2-HYDROXYESTRADIOL
METABOLITE -> PARENT
Structure of ESTRONE
METABOLITE -> PARENT
E2 is then extensively metabolized to estrone (E1) (15%), estrone sulfate (E1S) (65%), and other compounds.
Structure of .DELTA.6,7-ESTRADIOL
METABOLITE LESS ACTIVE -> PARENT
IN-VITRO
Structure of EC-508
PRODRUG -> METABOLITE ACTIVE
Structure of ESTRADIOL PARAQUINOL
PRODRUG -> METABOLITE ACTIVE
Structure of 16.ALPHA.-HYDROXYESTRONE
METABOLITE -> PARENT
IN-VIVO
URINE
Structure of ESTRAMUSTINE
PARENT -> METABOLITE
Metabolite produced by hydrolysis. Estramustine,s primary mechanism of antineoplastic action is inhibition of mitosis.
PLASMA
Structure of 2-HYDROXYESTRONE
METABOLITE -> PARENT
MAJOR
Structure of TESTOSTERONE
PARENT -> METABOLITE ACTIVE
Structure of 4-HYDROXYESTRADIOL
METABOLITE -> PARENT
Structure of 3,4-ESTRONE QUINONE
METABOLITE -> PARENT
IN-VITRO
Scientific Literature
Structure of ESTRAMUSTINE PHOSPHATE
PRODRUG -> METABOLITE ACTIVE
Related Record Type Details
Structure of ETHINYL ESTRADIOL
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of ESTRADIOL BENZOATE
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (TLC)
USP
Structure of 6.BETA.-HYDROXYESTRADIOL
IMPURITY -> PARENT
Structure of 6.ALPHA.-HYDROXYESTRADIOL
IMPURITY -> PARENT
Structure of ESTRADIOL CYPIONATE
PARENT -> IMPURITY
Structure of 6-KETOESTRADIOL
IMPURITY -> PARENT
Related Record Type Details
Structure of ESTRADIOL
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ESTRADIOL VALERATE

Single Dose

Volume of Distribution PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC ESTRADIOL VALERATE

Single Dose

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