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Details

Stereochemistry ACHIRAL
Molecular Formula C25H25F3N4O4
Molecular Weight 502.4856
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Naporafenib

SMILES

CC1=C(C=C(NC(=O)C2=CC(=NC=C2)C(F)(F)F)C=C1)C3=CC(=NC(OCCO)=C3)N4CCOCC4

InChI

InChIKey=UEPXBTCUIIGYCY-UHFFFAOYSA-N
InChI=1S/C25H25F3N4O4/c1-16-2-3-19(30-24(34)17-4-5-29-21(12-17)25(26,27)28)15-20(16)18-13-22(32-6-9-35-10-7-32)31-23(14-18)36-11-8-33/h2-5,12-15,33H,6-11H2,1H3,(H,30,34)

HIDE SMILES / InChI
Molecular Formula C25H25F3N4O4
Molecular Weight 502.4856
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
149124
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:23:02 GMT 2025
Edited
by admin
on Mon Mar 31 23:23:02 GMT 2025
Record UNII
15JL80DG6H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Naporafenib
INN   USAN  
Official Name English
ERAS-254
Preferred Name English
LXH-254
Code English
PAN-RAF INHIBITOR LXH254
Code English
LXH254
Code English
N-{3-[2-(2-hydroxethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide
Systematic Name English
naporafenib [INN]
Common Name English
NAPORAFENIB [USAN]
Common Name English
4-Pyridinecarboxamide, N-[3-[2-(2-hydroxyethoxy)-6-(4-morpholinyl)-4-pyridinyl]-4-methylphenyl]-2-(trifluoromethyl)-
Systematic Name English
Naporafenib [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C129825
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
NCI_THESAURUS C2336
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
Code System Code Type Description
NCI_THESAURUS
C125003
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
FDA UNII
15JL80DG6H
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
SMS_ID
300000027517
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
CAS
1800398-38-2
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
USAN
LM-238
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
PUBCHEM
90456533
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
INN
11398
Created by admin on Mon Mar 31 23:23:02 GMT 2025 , Edited by admin on Mon Mar 31 23:23:02 GMT 2025
PRIMARY
Related Record Type Details
SERINE/THREONINE-PROTEIN KINASE B-RAF V600E
TARGET -> INHIBITOR
Hill slope = -0.96
Ki
RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
TARGET -> INHIBITOR
IC50
SERINE/THREONINE-PROTEIN KINASE B-RAF V600E
TARGET -> INHIBITOR
IC50
SERINE/THREONINE-PROTEIN KINASE B-RAF
TARGET -> INHIBITOR
IC50
SERINE/THREONINE-PROTEIN KINASE B-RAF
TARGET -> INHIBITOR
Hill slope = -2.73
Ki
Related Record Type Details
Structure of Naporafenib
ACTIVE MOIETY
NIH
NCATS
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