SULINDAC

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H17FO3S
Molecular Weight	356.411
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of SULINDAC

Structure Search

SMILES

C[S+]([O-])C1=CC=C(\C=C2\C(C)=C(CC(O)=O)C3=C2C=CC(F)=C3)C=C1

InChI

InChIKey=MLKXDPUZXIRXEP-MFOYZWKCSA-N

InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

HIDE SMILES / InChI

Molecular Formula	C20H17FO3S
Molecular Weight	356.411
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 19:14:02 UTC 2023` Edited by `admin` on `Fri Dec 15 19:14:02 UTC 2023`
Record UNII	184SNS8VUH
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SULINDAC

Official Name

English

SULINDAC [ORANGE BOOK]

Common Name

English

ARTRIBID

Brand Name

English

CLINORIL

Brand Name

English

sulindac [INN]

Common Name

English

SULINDAC [JAN]

Common Name

English

SULINDAC [USAN]

Common Name

English

1H-INDENE-3-ACETIC ACID, 5-FLUORO-2-METHYL-1-((4-(METHYLSULFINYL)PHENYL)METHYLENE)-, (1Z)-

Common Name

English

ARTHROCINE

Brand Name

English

SULINDAC [USP-RS]

Common Name

English

SULINDAC [INCI]

Common Name

English

NSC-757344

Code

English

Sulindac [WHO-DD]

Common Name

English

SULINDAC [MART.]

Common Name

English

1H-INDENE-3-ACETIC ACID, 5-FLUORO-2-METHYL-1-((4-(METHYLSULFINYL)PHENYL)METHYLENE)-, (Z)-

Common Name

English

SULINDAC [USP MONOGRAPH]

Common Name

English

SULINDAC [EP MONOGRAPH]

Common Name

English

SULINDAC [MI]

Common Name

English

CIS-5-FLUORO-2-METHYL-1-((P-METHYLSULFINYL)BENZYLIDENE)INDENE-3-ACETIC ACID

Common Name

English

MK-231

Code

English

SULINDAC [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1323

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

WHO-ATC

M01AB02

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

NDF-RT

N0000175722

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

FDA ORPHAN DRUG

619917

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

LIVERTOX

NBK548315

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

FDA ORPHAN DRUG

387012

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

FDA ORPHAN DRUG

818421

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

WHO-VATC

QM01AB02

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

NDF-RT

N0000175721

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

NDF-RT

N0000000160

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

EU-Orphan Drug

EU/3/12/1086

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

FDA ORPHAN DRUG

752620

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

Code System Code Type Description

CHEBI

9352

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

NSC

757344

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

FDA UNII

184SNS8VUH

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

EVMPD

SUB10744MIG

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

EPA CompTox

DTXSID4023624

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

WIKIPEDIA

SULINDAC

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

IUPHAR

5425

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

PUBCHEM

1548887

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

SMS_ID

100000092515

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

INN

3791

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

DRUG CENTRAL

2534

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

CAS

38194-50-2

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

MERCK INDEX

m10382

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

Merck Index

NCI_THESAURUS

C850

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

LACTMED

Sulindac

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

DAILYMED

184SNS8VUH

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

RXCUI

10237

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

RxNorm

ChEMBL

CHEMBL15770

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

DRUG BANK

DB00605

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

RS_ITEM_NUM

1642008

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

ECHA (EC/EINECS)

253-819-2

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

MESH

D013467

Created by admin on Fri Dec 15 19:14:03 UTC 2023 , Edited by admin on Fri Dec 15 19:14:03 UTC 2023

PRIMARY

Related Record Type Details


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					ZWJ2Y6JZWY

OAT-3

TRANSPORTER -> INHIBITOR


					184SNS8VUH

SULINDAC

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

EP

Amount:


					BQG94QJ69I

ABCC-4

TRANSPORTER -> INHIBITOR


					I81U7H57XI

OAT-1

TRANSPORTER -> INHIBITOR


					4HZ67LW8L7

OAT-4

TRANSPORTER -> INHIBITOR


					5840721PJZ

OAT-2

TRANSPORTER -> INHIBITOR


					VK4SQL11C0

CYTOCHROME P450 1A2

METABOLIC ENZYME -> SUBSTRATE


					E6HDG0QI46

COX-1

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					184SNS8VUH

SULINDAC

BASIS OF STRENGTH->SUBSTANCE

Interaction Type:

ASSAY (TITRATION)

Qualification:

USP

Amount:

Related Record Type Details


					F52NEM6XFR

SULINDAC-SULFONE-GLUCURONIDE

METABOLITE -> PARENT


					V2VX8U6BY6

SULINDAC-GLUCURONIDE

METABOLITE -> PARENT


					6UVA8S2DEY

SULINDAC SULFIDE

METABOLITE ACTIVE -> PRODRUG

Comments:

Available evidence indicates that the biological activity resides with the sulfide metabolite.


					2JQ8X61QDQ

2-((3E)-6-FLUORO-2-(HYDROXYMETHYL)-3-((4-METHYLSULFINYLPHENYL)METHYLENE)INDEN-1-YL)ACETIC ACID

METABOLITE -> PARENT


					K619IIG2R9

EXISULIND

METABOLITE -> PARENT

Related Record Type Details


					6UVA8S2DEY

SULINDAC SULFIDE

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Ph.Eur.; USP

Amount:


					5NVO8803F9

SULINDAC, TRANS-

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Ph.Eur.; USP

Amount:


					K619IIG2R9

EXISULIND

IMPURITY -> PARENT

Interaction Type:

CHROMATOGRAPHIC PURITY (HPLC/UV)

Qualification:

Ph.Eur.; USP

Amount:

Related Record Type Details


					184SNS8VUH

SULINDAC

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

CSF/PLASMA RATIO	PHARMACOKINETIC