OAT-2

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 22:21:11 GMT 2025` Edited by `admin` on `Mon Mar 31 22:21:11 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	5840721PJZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MGC24091

Preferred Name

English

OAT-2

Common Name

English

OAT2

Common Name

English

ORGANIC ANION TRANSPORTER 2

Common Name

English

MGC45202

Common Name

English

SLC22A7

Common Name

English

NLT

Common Name

English

NOVEL LIVER TRANSPORTER

Common Name

English

Classification Tree Code System Code

UCSF-FDA TRANSPORTAL

SLC22A7

Created by admin on Mon Mar 31 22:21:11 GMT 2025 , Edited by admin on Mon Mar 31 22:21:11 GMT 2025

Code System Code Type Description

FDA UNII

5840721PJZ

Created by admin on Mon Mar 31 22:21:11 GMT 2025 , Edited by admin on Mon Mar 31 22:21:11 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_91

Related Record Type Details


					BKJ8M8G5HI

IMATINIB

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METHOTREXATE

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CHLOROTHIAZIDE

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TRICHLORMETHIAZIDE

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INHIBITOR -> TRANSPORTER

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INHIBITOR -> TRANSPORTER

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					2Z2A7OKI0A

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TISSUE EXPRESSION->TRANSPORTER

Comments:

Considerable role along with organic cation transporter 2 (OCT2), in the tubular secretion and thus renal clearance of creatinine.

Amount:


					H2D2X058MU

CYCLIC GMP

SUBSTRATE -> TRANSPORTER

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					0J48LPH2TH

HYDROCHLOROTHIAZIDE

INHIBITOR -> TRANSPORTER

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					4B9XT59T7S

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INHIBITOR -> TRANSPORTER

Comments:

Showed high in vivo inhibition potential due to the high unbound plasma concentrations attained at clinically relevant doses.

Amount:


					359HUE8FJC

PENCICLOVIR

SUBSTRATE -> TRANSPORTER

Amount:


					P9G3CKZ4P5

Ganciclovir

SUBSTRATE -> TRANSPORTER

Amount:


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SUBSTRATE -> TRANSPORTER

Amount:


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CEFAMANDOLE

INHIBITOR -> TRANSPORTER

Amount:


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INHIBITOR -> TRANSPORTER

Amount:


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Amount:


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Amount:


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Amount:


					XXE1CET956

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INHIBITOR -> TRANSPORTER

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Amount:


					P71U09G5BW

CYCLOTHIAZIDE

INHIBITOR -> TRANSPORTER

Amount:


					4T36H88UA7

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INHIBITOR -> TRANSPORTER

Amount:


					144O8QL0L1

DICLOFENAC

INHIBITOR -> TRANSPORTER

Amount:


					LVZ1VC61HB

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INHIBITOR -> TRANSPORTER

Amount:


					76LB1G2X6V

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INHIBITOR -> TRANSPORTER

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Amount:


					7LXU5N7ZO5

FUROSEMIDE

INHIBITOR -> TRANSPORTER

Amount:


					N2GI8B1GK7

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INHIBITOR -> TRANSPORTER

Amount:


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INHIBITOR -> TRANSPORTER

Amount:


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SUBSTRATE -> TRANSPORTER

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INHIBITOR -> TRANSPORTER

Amount:


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SUBSTRATE -> TRANSPORTER

Amount:


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SUBSTRATE -> TRANSPORTER

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL