U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C20H23N.ClH
Molecular Weight 313.864
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMITRIPTYLINE HYDROCHLORIDE

SMILES

Cl.CN(C)CCC=C1C2=C(CCC3=C1C=CC=C3)C=CC=C2

InChI

InChIKey=KFYRPLNVJVHZGT-UHFFFAOYSA-N
InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C20H23N
Molecular Weight 277.4033
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:39:04 UTC 2023
Edited
by admin
on Fri Dec 15 15:39:04 UTC 2023
Record UNII
26LUD4JO9K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMITRIPTYLINE HYDROCHLORIDE
EP   HSDB   MART.   MI   ORANGE BOOK   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [MI]
Common Name English
LIMBITROL DS COMPONENT AMITRIPTYLINE HYDROCHLORIDE
Common Name English
AMITRIPTYLINE HYDROCHLORIDE COMPONENT OF LIMBITROL DS
Common Name English
LIMBITROL COMPONENT AMITRIPTYLINE HYDROCHLORIDE
Common Name English
NSC-104210
Code English
AMITRIPTYLINE HYDROCHLORIDE [MART.]
Common Name English
AMITRIPTYLINI HYDROCHLORIDUM [WHO-IP LATIN]
Common Name English
SYNEUDON
Common Name English
Amitriptyline hydrochloride [WHO-DD]
Common Name English
ENDEP
Brand Name English
AMITID
Brand Name English
AMITRIPTYLINE HYDROCHLORIDE COMPONENT OF LIMBITROL
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [WHO-IP]
Common Name English
NOVOPROTECT
Common Name English
ELAVIL
Brand Name English
ETRAVIL
Brand Name English
AMITRIPTYLINE HYDROCHLORIDE [USP IMPURITY]
Common Name English
AMITRIL
Brand Name English
AMITRIPTYLINE HYDROCHLORIDE [EP IMPURITY]
Common Name English
ETRAFON-A COMPONENT AMITRIPTYLINE HYDROCHLORIDE
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [VANDF]
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [EP MONOGRAPH]
Common Name English
AMITRIPTYLINE HYDROCHLORIDE COMPONENT OF ETRAFON-A
Common Name English
NIH 10794
Code English
AMITRIPTYLINE HYDROCHLORIDE [USP MONOGRAPH]
Common Name English
AMITRIPTYLINE HCL
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [JAN]
Common Name English
AMITRIPTYLINE HYDROCHLORIDE [USP-RS]
Common Name English
1-PROPANAMINE, 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYL-, HYDROCHLORIDE
Systematic Name English
AMITRIPTYLINE HYDROCHLORIDE [HSDB]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C94727
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
Code System Code Type Description
RS_ITEM_NUM
1029002
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
CAS
549-18-8
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
DAILYMED
26LUD4JO9K
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
AMITRIPTYLINE HYDROCHLORIDE
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY Description: Colourless crystals or a white or almost white powder; odourless or almost odourless. Solubility: Soluble in 1 part of water and in 1.5 parts of ethanol (~750 g/l) TS; practically insoluble in ether R. Category: Antidepressant. Storage: Amitriptyline hydrochloride should be kept in a tightly closed container, protected from light. Additional information: Amitriptyline hydrochloride has a bitter and burning taste that is followed by a sensation of numbness. Even in the absence of light, Amitriptyline hydrochloride is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Definition: Amitriptyline hydrochloride contains not less than 99.0% and not more than 101.5% of C20H23N,HCl, calculated with reference to the dried substance.
SMS_ID
100000090311
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
ECHA (EC/EINECS)
208-964-6
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
PUBCHEM
11065
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
FDA UNII
26LUD4JO9K
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
DRUG BANK
DBSALT000009
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
MERCK INDEX
m1753
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY Merck Index
NSC
104210
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
ChEMBL
CHEMBL629
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
EVMPD
SUB00474MIG
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
NCI_THESAURUS
C28819
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
RXCUI
203168
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY RxNorm
EPA CompTox
DTXSID9033187
Created by admin on Fri Dec 15 15:39:04 UTC 2023 , Edited by admin on Fri Dec 15 15:39:04 UTC 2023
PRIMARY
Related Record Type Details
Structure of AMITRIPTYLINE HYDROCHLORIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
Structure of AMITRIPTYLINE
PARENT -> SALT/SOLVATE
Structure of AMITRIPTYLINE HYDROCHLORIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (HPLC)
USP
Related Record Type Details
Structure of NORTRIPTYLINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DIBENZOSUBEROL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of CYCLOBENZAPRINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of NORTRIPTYLINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of DIBENZOSUBERONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of AMITRIPTYNOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Structure of DIBENZOSUBERONE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of AMITRIPTYNOL
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of CYCLOBENZAPRINE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
Related Record Type Details
Structure of AMITRIPTYLINE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966