MINERALOCORTICOID RECEPTOR

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 16:49:27 GMT 2025` Edited by `admin` on `Tue Apr 01 16:49:27 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	33M0S99YTT
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MINERALOCORTICOID RECEPTOR

Common Name

English

ALDOSTERONE RECEPTOR

Preferred Name

English

NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 2,

Systematic Name

English

Code System Code Type Description

FDA UNII

33M0S99YTT

Created by admin on Tue Apr 01 16:49:27 GMT 2025 , Edited by admin on Tue Apr 01 16:49:27 GMT 2025

PRIMARY

WIKIPEDIA

MINERALOCORTICOID RECEPTOR

Created by admin on Tue Apr 01 16:49:27 GMT 2025 , Edited by admin on Tue Apr 01 16:49:27 GMT 2025

PRIMARY

Linkage Type	Residue Index
COORDINATION COMPOUND	1_639	1_645	1_655	1_658
COORDINATION COMPOUND	1_603	1_606	1_620

Related Record Type Details


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Comments:

Is a prodrug that Inhibits through active metabolites.

Amount:


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APARARENONE

INHIBITOR -> TARGET


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FINERENONE

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Interaction Type:

INHIBITOR

Qualification:

IC50

Amount:


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BALCINRENONE

PARTIAL ANTAGONIST->TARGET

Comments:

AZD9977 is a partial MR antagonist due to its unique interaction pattern with MR, which results in a distinct recruitment of co-factor peptides when compared to eplerenone. AZD9977 dose dependently reduced albuminuria and improved kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats. In acute testing, AZD9977 did not affect urinary Na+/K+ ratio

Amount:


					FO4V44A3G3

11-DEHYDROCORTICOSTERONE

AGONIST -> TARGET


					6FHZ595FNM

LY-2623091

INHIBITOR -> TARGET


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21-Desacetyldeflazacort

AGONIST -> TARGET

Interaction Type:

AGONIST

Qualification:

EC50

Amount:


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ESAXERENONE

INHIBITOR -> TARGET


					4964P6T9RB

ALDOSTERONE

AGONIST -> TARGET


					8XP29XMB43

Vamorolone

INHIBITOR -> TARGET

Amount:


					6995V82D0B

EPLERENONE

INHIBITOR -> TARGET

Amount:


					311Y5GV21M

MIRICORILANT

INHIBITOR -> TARGET


					L46509378R

OCEDURENONE

INHIBITOR -> TARGET

Amount:


					S4YT68R2XR

18-DEOXYALDOSTERONE

INHIBITOR -> TARGET

Interaction Type:

ANTAGONIST


					WI4X0X7BPJ

Hydrocortisone

AGONIST -> TARGET

Structural Modifications

Modification Type	Location Site	Location Type	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_603] [1_606] [1_620] [1_623]	SITE_SPECIFIC	C4-TYPE ZINC FINGER	C56TF4V7OP
AMINO_ACID_SUBSTITUTION	[1_639] [1_645] [1_655] [1_658]	SITE_SPECIFIC	C4-TYPE ZINC FINGER	C56TF4V7OP
AMINO ACID SUBSTITUTION	[1_250] [1_259] [1_283] [1_287] [1_299]		DEXFOSFOSERINE	VI4F0K069V

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT	CHEMICAL