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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H22N4O3
Molecular Weight 378.4244
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FINERENONE

SMILES

CCOC1=NC=C(C)C2=C1[C@H](C3=CC=C(C=C3OC)C#N)C(C(N)=O)=C(C)N2

InChI

InChIKey=BTBHLEZXCOBLCY-QGZVFWFLSA-N
InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m1/s1

HIDE SMILES / InChI
Molecular Formula C21H22N4O3
Molecular Weight 378.4244
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
123738
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:41:51 UTC 2023
Edited
by admin
on Sat Dec 16 05:41:51 UTC 2023
Record UNII
DE2O63YV8R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FINERENONE
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
finerenone [INN]
Common Name English
1,6-NAPHTHYRIDINE-3-CARBOXAMIDE, 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-1,4-DIHYDRO-2,8-DIMETHYL-, (4S)-
Systematic Name English
BAY 94-8862
Code English
FINERENONE [ORANGE BOOK]
Common Name English
FINERENONE [USAN]
Common Name English
KERENDIA
Brand Name English
FINERENONE [JAN]
Common Name English
Finerenone [WHO-DD]
Common Name English
BAY-94-8862
Code English
(4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID10146928
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
USAN
BC-45
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
NCI_THESAURUS
C169981
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
CAS
1050477-31-0
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
WIKIPEDIA
Finerenone
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
ChEMBL
CHEMBL2181927
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
SMS_ID
100000169992
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
INN
9634
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
PUBCHEM
60150535
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
FDA UNII
DE2O63YV8R
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
EVMPD
SUB183743
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
RXCUI
2562811
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
DAILYMED
DE2O63YV8R
Created by admin on Sat Dec 16 05:41:51 UTC 2023 , Edited by admin on Sat Dec 16 05:41:51 UTC 2023
PRIMARY
Related Record Type Details
Structure of FINERENONE
EXCRETED UNCHANGED
URINE
MINERALOCORTICOID RECEPTOR
TARGET -> INHIBITOR
CYTOCHROME P450 2C8
METABOLIC ENZYME -> SUBSTRATE
CYTOCHROME P450 3A4
METABOLIC ENZYME -> SUBSTRATE
MAJOR
Structure of FINERENONE
EXCRETED UNCHANGED
FECAL
Related Record Type Details
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-8-(HYDROXYMETHYL)-2-METHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
URINE
Structure of 1,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID, 3-(AMINOCARBONYL)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2-METHYL-, (4S)-
METABOLITE -> PARENT
PLASMA
Structure of 1,6-NAPHTHYRIDINE-3-CARBOXAMIDE, 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-8-(HYDROXYMETHYL)-2-METHYL-, (4S)-
METABOLITE -> PARENT
URINE
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-8-(HYDROXYMETHYL)-2-METHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
PLASMA
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
PLASMA
Structure of 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
MINOR
FECAL
Structure of 1,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID, 3-(AMINOCARBONYL)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2-METHYL-, (4S)-
METABOLITE -> PARENT
URINE
Structure of 1,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID, 3-(AMINOCARBONYL)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2-METHYL-, (4S)-
METABOLITE -> PARENT
FECAL
Structure of 1,6-NAPHTHYRIDINE-3-CARBOXAMIDE, 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-8-(HYDROXYMETHYL)-2-METHYL-, (4S)-
METABOLITE -> PARENT
FECAL
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
PLASMA
Structure of 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
MAJOR
PLASMA
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-8-(HYDROXYMETHYL)-2-METHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
FECAL
Structure of (4S)-3-CARBAMOYL-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-2-METHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID
METABOLITE -> PARENT
URINE
Structure of (4S)-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE
METABOLITE -> PARENT
URINE
Structure of 1,6-NAPHTHYRIDINE-3-CARBOXAMIDE, 4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-8-(HYDROXYMETHYL)-2-METHYL-, (4S)-
METABOLITE -> PARENT
PLASMA
Structure of (4S)-3-CARBAMOYL-4-(4-CYANO-2-METHOXY-PHENYL)-5-ETHOXY-2,3-DIHYDROXY-2-METHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-8-CARBOXYLIC ACID
METABOLITE -> PARENT
FECAL
Related Record Type Details
Structure of FINERENONE
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