NALOXONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H21NO4
Molecular Weight	327.3743
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of NALOXONE

Structure Search

SMILES

[H][C@@]12OC3=C4C(C[C@H]5N(CC=C)CC[C@@]14[C@@]5(O)CCC2=O)=CC=C3O

InChI

InChIKey=UZHSEJADLWPNLE-GRGSLBFTSA-N

InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C19H21NO4
Molecular Weight	327.3743
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:12:56 UTC 2023` Edited by `admin` on `Fri Dec 15 15:12:56 UTC 2023`
Record UNII	36B82AMQ7N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NALOXONE

Official Name

English

17-ALLYL-4,5A-EPOXY-3,14-DIHYDROXYMORPHINAN-6-ONE

Common Name

English

NALOXONE [MI]

Common Name

English

DBL NALOXONE

Brand Name

English

Naloxone [WHO-DD]

Common Name

English

(-)-N-ALLYL-14-HYDROXYNORDIHYDROMORPHINONE

Common Name

English

MORPHINAN-6-ONE, 4,5-EPOXY-3,14-DIHYDROXY-17-(2-PROPENYL)-

Systematic Name

English

NALOXONE [VANDF]

Common Name

English

NALOXONE [USP-RS]

Common Name

English

NALOXONE [EMA EPAR]

Common Name

English

NSC-70413

Code

English

naloxone [INN]

Common Name

English

NALOXONE [ORANGE BOOK]

Common Name

English

NALOXONE [HSDB]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

280209

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

WHO-ESSENTIAL MEDICINES LIST

4.2

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

NDF-RT

N0000000154

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

EMA ASSESSMENT REPORTS

SUBOXONE (AUTHORIZED: OPIOID-RELATED DISEASES)

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

WHO-VATC

QV03AB15

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

FDA ORPHAN DRUG

79093

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

WHO-ATC

V03AB15

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

WHO-ATC

A06AH04

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

LIVERTOX

NBK548244

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

NDF-RT

N0000175691

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

WHO-ATC

N02AA53

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

NCI_THESAURUS

C681

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

Code System Code Type Description

ChEMBL

CHEMBL80

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

LACTMED

Naloxone

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

CHEBI

7459

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

PUBCHEM

5284596

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

SMS_ID

100000085468

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

WIKIPEDIA

NALOXONE

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

DRUG CENTRAL

1878

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

RXCUI

7242

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

RxNorm

DAILYMED

36B82AMQ7N

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

EVMPD

SUB09142MIG

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

INN

1526

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

EPA CompTox

DTXSID8023349

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

MESH

D009270

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

FDA UNII

36B82AMQ7N

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

DRUG BANK

DB01183

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

NCI_THESAURUS

C62054

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

RS_ITEM_NUM

1453005

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

IUPHAR

1638

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

HSDB

3279

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

ECHA (EC/EINECS)

207-365-7

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

NSC

70413

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

MERCK INDEX

m7717

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

Merck Index

CAS

465-65-6

Created by admin on Fri Dec 15 15:12:56 UTC 2023 , Edited by admin on Fri Dec 15 15:12:56 UTC 2023

PRIMARY

Related Record Type Details


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Interaction Type:

BINDING

Qualification:

IC50

Amount:


					P7WJA2YB2Y

DINALOXONE PAMOATE

SALT/SOLVATE -> PARENT

Amount:


					SIDP85PFD6

ESTROGEN RECEPTOR

TARGET -> INHIBITOR

Amount:


					EV0PWK6TT6

DELTA-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Qualification:

IC50

Amount:


					0M77ZW789J

URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 2B7

METABOLIC ENZYME -> SUBSTRATE


					F850569PQR

NALOXONE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					5Q187997EE

NALOXONE HYDROCHLORIDE DIHYDRATE

SALT/SOLVATE -> PARENT

Amount:


					Q33JU1X13B

NALOXONE PAMOATE

SALT/SOLVATE -> PARENT

Amount:


					2BJ58BX78W

KAPPA-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Comments:

Naloxone is a non-selective and competitive opioid receptor antagonist

Qualification:

IC50

Amount:


					0W13ZI072Q

NALOXONE BENZOYLHYDRAZONE

DERIVATIVE -> PARENT

Amount:


					1PE72K8X46

MU-TYPE OPIOID RECEPTOR

TARGET -> INHIBITOR

Comments:

Mu Receptor [3H]DAMGO BINDING INHIBITION

Interaction Type:

BINDING

Qualification:

Ki

Amount:

Related Record Type Details


					FLW43Q2H9L

.ALPHA.-NALOXOL

METABOLITE LESS ACTIVE -> PARENT

Comments:

Results also indicate that delay in onset of action of 6-alpha-naloxol at opioid receptors in the central nervous system may contribute significantly to its reduced potency relative to naloxone under certain morphine pretreatment conditions.

Amount:


					9NZ7111A9O

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					86O922U8J0

NALOXONE-3-GLUCURONIDE

METABOLITE -> PARENT

Interaction Type:

MAJOR

Qualification:

URINE

Amount:


					FLW43Q2H9L

.ALPHA.-NALOXOL

METABOLITE -> PARENT

Qualification:

URINE

Amount:


					86O922U8J0

NALOXONE-3-GLUCURONIDE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					36B82AMQ7N

NALOXONE

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Biological Half-life	PHARMACOKINETIC

Tmax	PHARMACOKINETIC