Trastuzumab brengitecan

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:54:35 GMT 2025` Edited by `admin` on `Wed Apr 02 17:54:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	5MHN3G4T8J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G1 [de-450-lysine], anti-(human epidermal growth factor receptor HER2) (human-Mus musculus monoclonal BL-M07D1 ?1-chain), complex with human-Mus musculus monoclonal BL-M07D1 ?-chain, dimer, 214??,214???,223,223?,229,229?,232,232?-octakis(t

Preferred Name

English

Trastuzumab brengitecan

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ERBB2 (receptor tyrosine-protein kinase erbB-2, epidermal growth factor receptor 2, EGFR2, HER2, HER-2, p185c-erbB2, NEU, CD340)], humanized monoclonal antibody, conjugated to a camptothecin derivative

Common Name

English

trastuzumab brengitecan [INN]

Common Name

English

Code System Code Type Description

INN

12677

Created by admin on Wed Apr 02 17:54:35 GMT 2025 , Edited by admin on Wed Apr 02 17:54:35 GMT 2025

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FDA UNII

5MHN3G4T8J

Created by admin on Wed Apr 02 17:54:35 GMT 2025 , Edited by admin on Wed Apr 02 17:54:35 GMT 2025

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CAS

2761149-81-7

Created by admin on Wed Apr 02 17:54:35 GMT 2025 , Edited by admin on Wed Apr 02 17:54:35 GMT 2025

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NCI_THESAURUS

C203071

Created by admin on Wed Apr 02 17:54:35 GMT 2025 , Edited by admin on Wed Apr 02 17:54:35 GMT 2025

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SMS_ID

300000054846

Created by admin on Wed Apr 02 17:54:35 GMT 2025 , Edited by admin on Wed Apr 02 17:54:35 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					7J9Y28299R

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2

TARGET -> INHIBITOR

Amount:


					P188ANX8CK

PARENT -> CONJUGATE

Amount:


					XT3Z54Z28A

CONJUGATE COMPONENT->CONJUGATE

Amount:

Related Record Type Details


					5MHN3G4T8J

Trastuzumab brengitecan

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC	C	Amount:	UNSPECIFIED SUBSTANCE	97a279ed (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL