Approval Year
| Substance Class |
Structurally Diverse
Created
by
admin
on
Edited
Mon Mar 31 18:17:04 GMT 2025
by
admin
on
Mon Mar 31 18:17:04 GMT 2025
|
| Source Materials Class | ORGANISM |
| Source Materials Type | VIRUS |
| Organism Family | Hepadnaviridae |
| Organism Genus | Orthohepadnavirus |
| Organism Species | hepatovirus b |
| Author | NONE |
| Part | whole |
| Record UNII |
77H9EM77P7
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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SUB25281
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
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PRIMARY | |||
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77H9EM77P7
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
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PRIMARY | |||
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1427211
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
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PRIMARY | RxNorm | ||
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C14215
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
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PRIMARY | |||
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10407
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
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PRIMARY | |||
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77H9EM77P7
Created by
admin on Mon Mar 31 18:17:04 GMT 2025 , Edited by admin on Mon Mar 31 18:17:04 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
BLOCKS VIRAL ENTRY BY BINDING TO SODIUM/BILE ACID COTRANSPORTER
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INHIBITOR->TARGET ORGANISM |
EC50
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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VACCINE ANTIGEN->TARGET ORGANISM |
T-cell antigen
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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VACCINE ANTIGEN->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
EC50
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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VACCINE ANTIGEN->TARGET ORGANISM |
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VACCINE ANTIGEN->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
INHIBITS CAPSID ASSEMBLY
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
Median 50% effective concentration (EC50) values across all genotypes were 10–33 nM
versus 17 nM (genotype D reference). Prevents nucleic acid incorporation into capsid.
EC50
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VACCINE ANTIGEN->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
Inhibits capsid assembly
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INFRASPECIFIC -> PARENT ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
HBV DNA. Highly selective for HBV.
IC50
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INHIBITOR->TARGET ORGANISM |
IC50
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INHIBITOR->TARGET ORGANISM |
inhibition of hepatitis B virus (HBV) capsid assembly
EC50
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VACCINE ANTIGEN->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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VACCINE ANTIGEN->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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INHIBITOR->TARGET ORGANISM |
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![Structure of Methyl (3R,6S)-6-[(aminosulfonyl)amino]-3,5,6,7-tetrahydro-1-(2-thiazolyl)-3-(2,3,4-trifluorophenyl)pyrrolo[1,2-c]pyrimidine-4-carboxylate](/img/fa544b0d-06e3-4884-a2a7-ad840ec467b9.svg "Structure of Methyl (3R,6S)-6-[(aminosulfonyl)amino]-3,5,6,7-tetrahydro-1-(2-thiazolyl)-3-(2,3,4-trifluorophenyl)pyrrolo[1,2-c]pyrimidine-4-carboxylate")
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
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