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Details

Stereochemistry ACHIRAL
Molecular Formula C12H11ClN2O5S
Molecular Weight 330.744
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FUROSEMIDE

SMILES

NS(=O)(=O)C1=CC(C(O)=O)=C(NCC2=CC=CO2)C=C1Cl

InChI

InChIKey=ZZUFCTLCJUWOSV-UHFFFAOYSA-N
InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

HIDE SMILES / InChI
Molecular Formula C12H11ClN2O5S
Molecular Weight 330.744
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:07:40 UTC 2023
Edited
by admin
on Fri Dec 15 15:07:40 UTC 2023
Record UNII
7LXU5N7ZO5
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FUROSEMIDE
EP   GREEN BOOK   HSDB   INN   MART.   MI   ORANGE BOOK   USAN   USP   USP-RS   VANDF   WHO-DD   WHO-IP  
USAN   INN  
Official Name English
5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURYLMETHYL)AMINO)BENZOIC ACID
Systematic Name English
Furosemide [WHO-DD]
Common Name English
BENZOIC ACID, 5-(AMINOSULFONYL)-4-CHLORO-2-((2-FURANYLMETHYL)AMINO)-
Common Name English
LOGIRENE
Brand Name English
FUROSEMIDE [IARC]
Common Name English
FUROSEMIDE [ORANGE BOOK]
Common Name English
FUROSEMIDE [EP MONOGRAPH]
Common Name English
FUROSEMIDE [WHO-IP]
Common Name English
FUROSEMIDE [VANDF]
Common Name English
FUROSCIX
Brand Name English
LB-502
Code English
OEDEMEX
Common Name English
FUROSEMIDE [JAN]
Common Name English
FUROSEMIDUM [WHO-IP LATIN]
Common Name English
FUROSEMIDE [USP MONOGRAPH]
Common Name English
FRUSEMIDE
Common Name English
FUROSEMIDE [GREEN BOOK]
Common Name English
MARSEMIDE
Common Name English
furosemide [INN]
Common Name English
LASIX
Brand Name English
MIRFAT
Brand Name English
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
Systematic Name English
NSC-269420
Code English
FUROSEMIDE [MART.]
Common Name English
FUROSEMIDE [MI]
Common Name English
FUROSEMIDE [HSDB]
Common Name English
FUROSEMIDE [USAN]
Common Name English
FUROSEMIDE [USP-RS]
Common Name English
Classification Tree Code System Code
WHO-ESSENTIAL MEDICINES LIST 12.4
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
CFR 21 CFR 522.1010
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
NDF-RT N0000175590
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-VATC QC03CB01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-ATC C03EB01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
LIVERTOX 445
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
NCI_THESAURUS C49184
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-VATC QC03EB01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-ESSENTIAL MEDICINES LIST 16
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-ATC C03CA01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
NDF-RT N0000175366
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-ATC C03CB01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
CFR 21 CFR 520.1010
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
WHO-VATC QC03CA01
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
Code System Code Type Description
IUPHAR
4839
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
ChEMBL
CHEMBL35
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
RXCUI
4603
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY RxNorm
WIKIPEDIA
FUROSEMIDE
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
CHEBI
47426
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
FDA UNII
7LXU5N7ZO5
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
MESH
D005665
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
ECHA (EC/EINECS)
200-203-6
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
NSC
269420
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
RS_ITEM_NUM
1287008
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID6020648
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
DRUG BANK
DB00695
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
MERCK INDEX
m5608
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY Merck Index
SMS_ID
100000090317
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
FUROSEMIDE
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY Description: A white or almost white, crystalline powder; odourless. Solubility: Practically insoluble in water; soluble in 75 parts of ethanol (~750 g/l) TS; slightly soluble in ether R. Category: Diuretic. Storage: Furosemide should be kept in a well-closed container, protected from light. Definition: Furosemide contains not less than 98.0% and not more than 101.0% of C12H11ClN2O5S, calculated with reference to the dried substance.
CAS
54-31-9
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
NCI_THESAURUS
C515
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
LACTMED
Furosemide
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
HSDB
3086
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
PUBCHEM
3440
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
DAILYMED
7LXU5N7ZO5
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
INN
1584
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
DRUG CENTRAL
1258
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
EVMPD
SUB07849MIG
Created by admin on Fri Dec 15 15:07:40 UTC 2023 , Edited by admin on Fri Dec 15 15:07:40 UTC 2023
PRIMARY
Related Record Type Details
SOLUTE CARRIER FAMILY 12 MEMBER 1
TARGET -> INHIBITOR
POTENCY
OAT-2
TRANSPORTER -> INHIBITOR
URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE 1A9
METABOLIC ENZYME -> SUBSTRATE
Structure of FUROSEMIDE SODIUM
SALT/SOLVATE -> PARENT
Structure of FUROSEMIDE HYDROCHLORIDE
SALT/SOLVATE -> PARENT
OAT-3
TRANSPORTER -> INHIBITOR
Structure of FUROSEMIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
EP
SODIUM/BILE ACID COTRANSPORTER
TRANSPORTER -> INHIBITOR
Structure of FUROSEMIDE
BASIS OF STRENGTH->SUBSTANCE
ASSAY (TITRATION)
USP
Structure of FUROSEMIDE DIETHYLAMINOETHANOL
SALT/SOLVATE -> PARENT
PLASMA PROTEIN FRACTION (HUMAN)
BINDER->LIGAND
BINDING
OAT-4
TRANSPORTER -> INHIBITOR
Related Record Type Details
Structure of FUROSEMIDE GLUCURONIDE
METABOLITE -> PARENT
Structure of 4-CHLORO-5-SULFAMOYLANTHRANILIC ACID
METABOLITE -> PARENT
MAJOR
Related Record Type Details
Structure of ISOFUROSEMIDE
IMPURITY -> PARENT
Structure of 2,4-DICHLOROBENZOIC ACID
IMPURITY -> PARENT
Structure of 2,4-BIS((FURAN-2-YLMETHYL)AMINO)-5-SULFAMOYLBENZOIC ACID
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 2.0
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 2,4-DICHLORO-5-SULFAMOYLBENZOIC ACID
IMPURITY -> PARENT
Structure of 4-CHLORO-5-SULFAMOYL-2-((((2RS)-TETRAHYDROFURAN-2-YL)METHYL)AMINO)BENZOIC ACID
IMPURITY -> PARENT
Structure of 4-CHLORO-5-SULFAMOYLANTHRANILIC ACID
IMPURITY -> PARENT
For the calculation of contents, multiply the peak areas by 1.4
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of FUROSEMIDE
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
ORAL BIOAVAILABILITY PHARMACOKINETIC
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
MAXIMUM TOLERATED DOSE TOXICITY
Tmax PHARMACOKINETIC ORAL SOLUTION
PHARMACOKINETIC
SL TABLET
PHARMACOKINETIC
ORAL TABLET
PHARMACOKINETIC
NIH
NCATS
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