HISTAMINE

US Approved Rx (1999)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C5H9N3
Molecular Weight	111.1451
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NCCC1=CNC=N1

InChI

InChIKey=NTYJJOPFIAHURM-UHFFFAOYSA-N

InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)

HIDE SMILES / InChI

Molecular Formula	C5H9N3
Molecular Weight	111.1451
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26084539 | https://www.drugs.com/pro/histamine-phosphate.html | https://www.drugs.com/mmx/histamine-phosphate.html

Histamine is a depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and a centrally acting neurotransmitter. Phosphate salt of jistamine was used as a diagnostic aid for evaluation of gastric acid secretory function. In addition, this compound is used as a positive control in evaluation of allergenic (immediate hypersensitivity or "Type I") skin testing. In addition, histamine is being studied for treatment of multiple sclerosis. It was approved, that histamine physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention. The receptors display molecular heterogeneity and constitutive activity. H1R antagonists are long known antiallergic and sedating drugs, whereas the H2R led to the development of H2R-antagonists that revolutionized stomach ulcer treatment. The H3R is an auto receptor and heteroreceptor providing negative feedback on histaminergic and inhibition on other neurons. The H4R occurs on immuncompetent cells and the development of anti-inflammatory drugs is anticipated.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 316 Target ID: CHEMBL231 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16648669	Agonist 2752
Histamine H2 receptor 46 Target ID: CHEMBL1941 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26084539	Agonist 2752
Histamine H3 receptor 46 Target ID: CHEMBL264 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17652997	Agonist 2752
Histamine H4 receptor 20 Target ID: CHEMBL3759 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26084539	Agonist 2752

Conditions

Condition	Modality	Highest Phase	Product
Allergenic skin 4 Sources: https://www.drugs.com/pro/histamine-phosphate.html	Diagnostic	Not Provided 511	HISTAMINE PHOSPHATE Approved Use Indications and Usage Uses temporarily relieves symptoms due to sinus discomforts associated with inflamed sinuses, hay fever or upper respiratory allergies: sinus pain and pressure runny nose sinus headaches sore throat nasal congestion dry mucus membranes sneezing itchy, burning eyes Reference image sinus.jpg Launch Date 1939
Multiple sclerosis 107 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20493888	Primary	Basic research	Unknown Approved Use Unknown
Gastric acid secretory 4 Sources: https://www.drugs.com/mmx/histamine-phosphate.html	Diagnostic	Approved 8583	HISTAMINE PHOSPHATE Approved Use Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function. Anacidity (achlorhydria) in response to histamine may indicate pernicious anemia, atrophic gastritis, adenomatous polyps of stomach, or gastric carcinoma. Gastric hypersecretion in response to histamine may indicate duodenal ulcer or the Zollinger-Ellison syndrome. Launch Date 1939

C_max

Value	Dose	Co-administered	Analyte	Population
39 nM EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12092744	1 mg single, subcutaneous dose: 1 mg route of administration: Subcutaneous experiment type: SINGLE co-administered:		HISTAMINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
1877 nM × min EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12092744	1 mg single, subcutaneous dose: 1 mg route of administration: Subcutaneous experiment type: SINGLE co-administered:		HISTAMINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
12 min EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/12092744	1 mg single, subcutaneous dose: 1 mg route of administration: Subcutaneous experiment type: SINGLE co-administered:		HISTAMINE plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: FASTED

Doses

Dose	Population	Adverse events
0.03 mg single, intravenous Highest studied dose Dose: 0.03 mg Route: intravenous Route: single Dose: 0.03 mg Sources: https://pubmed.ncbi.nlm.nih.gov/16695374	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/16695374	Sources: https://pubmed.ncbi.nlm.nih.gov/16695374
0.2 mg single, intramuscular Highest studied dose Dose: 0.2 mg Route: intramuscular Route: single Dose: 0.2 mg Sources: https://pubmed.ncbi.nlm.nih.gov/16695374	unhealthy Health Status: unhealthy Sex: M Sources: https://pubmed.ncbi.nlm.nih.gov/16695374	Sources: https://pubmed.ncbi.nlm.nih.gov/16695374

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
	OCT2 434 OCT3 92

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
OCT2 434	substrate 4014 Sources: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_0_0604270010/_article/-char/ja/ Page: -	yes
OCT3 92	substrate 4014 Sources: https://www.jstage.jst.go.jp/article/jphs/advpub/0/advpub_0_0604270010/_article/-char/ja/ Page: -	yes

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY557484	https://www.001chemical.com/chem/51-45-6
3B Scientific (Wuhan) Corp	3B3-033520	http://www.3bsc.com/index/pro_info.php?id=54784
AA Blocks	AA0037B9	http://www.aablocks.com/goods/Goods/detail?id=AA0037B9
Aaron Chemicals	AR003831	http://www.aaronchem.com/51-45-6
abcr GmbH	AB349089	http://www.abcr.com/shop/en/AB349089
abcr GmbH	AB511890	http://www.abcr.com/shop/en/AB511890
AbMole Bioscience	M5692	http://www.abmole.com/products/histamine.html
Acadechem	ACDS-017396	http://www.acadechemical.com/product/92095
Accela ChemBio Inc	SY041787	http://www.accelachem.com/cn/search.html?keyword=SY041787&attname=GoodsCode
Achemo Scientific Limited	AC-45306	http://www.achemo.com/search/?Keyword=51-45-6
Achemtek	0104-056461	http://www.achemtek.com/51-45-6
Acros Organics	AC411710010	https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710010
Acros Organics	AC411710050	https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710050
Acros Organics	AC411710250	https://www.fishersci.com/shop/products/histamine-97-acros-organics/AC411710250
AHH Chemical co.,ltd	MB-01356	http://www.ahhchemical.com/product/MB-01356.html
AHH Chemical co.,ltd	MT-52563	http://www.ahhchemical.com/product/MT-52563.html
AK Scientific, Inc. (AKSCI)	Y9749	http://www.aksci.com/item_detail.php?cat=Y9749
Alfa Chemistry	51-45-6	https://www.alfa-chemistry.com/histamine-cas-51-45-6-item-292336.htm
Alfa Chemistry	AP51456-A	https://reagents.alfa-chemistry.com/product/histamine-cas-51-45-6-12315.html
Alfa Chemistry	AP51456-B	https://reagents.alfa-chemistry.com/product/histamine-free-base-cas-51-45-6-cas-51-45-6-12316.html
Alichem	69004288	http://www.alichem.com/en/products/65592-96-3.html
Alinda	ALBB-005968	http://alinda.ru/finechem_en_.html?i=ALBB-005968
Ambeed	A804010	https://www.ambeed.com/products/51-45-6.html
Ambinter	Amb1101977	http://www.ambinter.com/reference/1101977
Angene	AGN-PC-007FY2	http://www.angenechemical.com/productshow/AGN-PC-007FY2.html
Angene	AGN-PC-0TH9T7	http://www.angenechemical.com/productshow/AGN-PC-0TH9T7.html
Anward	ANW-50461	http://www.anward.com/pro_result/36912
Aurora Fine Chemicals LLC	A00.704.248	http://online.aurorafinechemicals.com/info?ID=A00.704.248
Aurora Fine Chemicals LLC	K01.795.228	http://online.aurorafinechemicals.com/info?ID=K01.795.228
Aurum Pharmatech LLC	C-5322	http://www.Aurumpharmatech.com/Product/ProductDetails/C_5322
Avantor Inc	101186-436	https://us.vwr.com/store/catalog/product.jsp?catalog_number=101186-436
BioCrick	BCN2188	http://www.biocrick.com/Histamine-BCN2188.html
BioSynth	J-505349	https://www.biosynth.com/en/products/all-products/products/J-505349.html
BLD Pharm	BD41747	http://www.bldpharm.com/products/51-45-6.html
BLD Pharm	BD61796	http://www.bldpharm.com/products/65592-96-3.html
BOC Sciences	344299-48-5	https://isotope.bocsci.com/product/histamine-d4-dihydrochloride-cas-344299-48-5-110348.html
Boerchem	BC205752	http://www.boerchem.com/?product_34681.html
BroadPharm	BP-11484	http://www.broadpharm.com/products/Amines/BP-11484/
Calbiochem	3779	http://www.emdbiosciences.com/product/3779
Chem Scene	CS-4697	http://www.chemscene.com/51-45-6.html
Chemenu	CM117809	http://www.chemenu.com/products/CM117809
ChemFaces	CFN90029	http://www.chemfaces.com/natural/Histamine-CFN90029.html
ChemMol	30102836	http://www.chemmol.com/chemmol/30102836.html
ChemMol	44002277	http://www.chemmol.com/chemmol/44002277.html
ChemMol	49403308	http://www.chemmol.com/chemmol/49403308.html
ChemMol	49417190	http://www.chemmol.com/chemmol/49417190.html
ChemMol	49425866	http://www.chemmol.com/chemmol/49425866.html
Chemspace	CSSB00000756591	https://chem-space.com/CSSB00000756591
Clearsynth	CS-M-25829	https://www.clearsynth.com/en/CSM25829.html
CSNpharm	CSN16747	https://www.csnpharm.com/products/histamine.html
EMD Millipore	3779	http://www.emdbiosciences.com/product/3779
eNovation Chemicals	D382889	http://www.enovationchem.com/productDetails.asp?productID=D382889
eNovation Chemicals	D914693	https://www.enovationchem.com/ProductDetails.asp?ProductID=D914693
eNovation Chemicals	K66466	https://www.enovationchem.com/ProductDetails.asp?ProductID=K66466
eNovation Chemicals	Y1043716	https://www.enovationchem.com/ProductDetails.asp?ProductID=Y1043716
Finetech	FT-0627839	http://www.finetechnology-ind.com/prod/detail/pub/51-45-6.html
Glentham Life Sciences	GL9196	http://www.glentham.com/products/product/GL9196/
Hairui	HR122599	http://www.hairuichem.com/en/product/51-45-6.html
iChemical	EBD6913	http://www.ichemical.com/products/51-45-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
Lab Network	LN00011223	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00011223
Matrix Scientific	133714	https://www.matrixscientific.com/133714.html
mcule	MCULE-4970362785	https://mcule.com/MCULE-4970362785/
MedChem Express	HY-B1204	https://www.medchemexpress.com/Histamine.html
Molcore	MC557484	https://www.molcore.com/product/51-45-6
MuseChem	I003852	https://www.musechem.com/product/I003852.html
Oakwood	78943	http://www.oakwoodchemical.com/ProductsList.aspx?CategoryID=-2&txtSearch=64117&ExtHyperLink=1
OChem	11930	http://www.ocheminc.com/index.php?act=psearch&pid=056H928
OChem	3670	http://www.ocheminc.com/index.php?act=psearch&pid=714I940
Otava	2816948	https://search.otavachemicals.com/#!/search?query=2816948&type=code&base=dbb
Parchem	29572	https://www.parchem.com/chemical-supplier-distributor/Histamine-029572.aspx
Parchem	Histamine	http://www.parchem.com/chemical-supplier-distributor/Histamine-029572.aspx
Renno Tech	RP00535	http://www.rennotech.com/product_show.asp?id=6925
Selleck Chemicals	S3968	http://www.selleckchem.com/products/histamine.html
Sigma-Aldrich	53290_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/53290?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	59964_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/59964?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	H7125_SIGMA	https://www.sigmaaldrich.com/catalog/product/sigma/h7125?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	V900396_VETEC	https://www.sigmaaldrich.com/catalog/product/vetec/v900396?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	Y0001779_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/y0001779?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sinfoo Biotech	S001739	http://www.sinfoobiotech.com/product/1005137
Smolecule	S590017	https://www.smolecule.com/products/s590017
THE BioTek	bt-301933	https://www.thebiotek.com/product/others/bt-301933
VladaChem	VL270045-1G	https://www.vladachem.com/product.php?products=51-45-6
Yuhao Chemical	HL1018	http://www.chemyuhao.com/51-45-6.html

PubMed

Title	Date	PubMed
The physiology of brain histamine.	2001-04	11164999
Decreased brain histamine-releasing factor protein in patients with Down syndrome and Alzheimer's disease.	2001-03-02	11172935
Glycine receptor mediated responses in rat histaminergic neurons.	2001-03-02	11172926
Correlation between neutral endopetidase (NEP) 3.4.24.11 in serum and the degree of the bronchial hyperreactivity.	2001-03-02	11164954
Neurohormonal regulation of secretion from isolated rat stomach ECL cells: a critical reappraisal.	2001-03-02	11164953
Extracts of ECL-cell granules/vesicles and of isolated ECL cells from rat oxyntic mucosa evoke a Ca2+ second messenger response in osteoblastic cells.	2001-03-02	11164951
CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae.	2001-03	11171673
Differences in Ca(2+) signaling underlie age-specific effects of secretagogues on colonic Cl(-) transport.	2001-03	11171585
Interactions of inflammatory mediators stimulating release of calcitonin gene-related peptide, substance P and prostaglandin E(2) from isolated rat skin.	2001-03	11166334
Complement-dependent immune complex-induced bronchial inflammation and hyperreactivity.	2001-03	11159035
Ontogeny of modulatory inputs to motor networks: early established projection and progressive neurotransmitter acquisition.	2001-02-15	11160402
IL-13 overexpression predisposes to anaphylaxis following antigen sensitization.	2001-02-15	11160336
Selective down-regulation of high-affinity IgE receptor (FcepsilonRI) alpha-chain messenger RNA among transcriptome in cord blood-derived versus adult peripheral blood-derived cultured human mast cells.	2001-02-15	11159531
Food-deprived activity stress decreased the activity of the histaminergic neuron system in rats.	2001-02-09	11164807
The activation of synovial mast cells: modulation of histamine release by tryptase and chymase and their inhibitors.	2001-02-02	11166285
Involvement of central histaminergic neurons in polypnea induced by hyperthermia in rabbits.	2001-02-02	11163292
Mesenchymal transcription factor Fkh6 is essential for the development and differentiation of parietal cells.	2001-02-02	11162636
Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids.	2001-02	11179114
Diphenhydramine for the prevention of akathisia induced by prochlorperazine: a randomized, controlled trial.	2001-02	11174228
No correlation between wine intolerance and histamine content of wine.	2001-02	11174207
IL-18 might reflect disease activity in mild and moderate asthma exacerbation.	2001-02	11174201
Histamine alters gene expression in cultured human nasal epithelial cells.	2001-02	11174198
Acquisition and alteration of adhesion molecules during cultured human mast cell differentiation.	2001-02	11174197
IL-4 production by human basophils found in the lung following segmental allergen challenge.	2001-02	11174192
Histamine prevents polyamine accumulation in mouse C57.1 mast cell cultures.	2001-02	11168417
Double-blind, placebo-controlled food challenge with apple.	2001-02	11167370
Inhibitory action of water soluble fraction of Terminalia chebula on systemic and local anaphylaxis.	2001-02	11167031
Characterization of a novel cationic drug transporter in human retinal pigment epithelial cells.	2001-02	11160630
Chronic tobacco smoke exposure increases airway sensitivity to capsaicin in awake guinea pigs.	2001-02	11160071
Nedocromil sodium inhibits histamine-induced itch and flare in human skin.	2001-02	11159712
A human tissue-engineered vascular media: a new model for pharmacological studies of contractile responses.	2001-02	11156967
Luminal Nalpha-methyl histamine stimulates gastric acid secretion in duodenal ulcer patients via releasing gastrin.	2001-01-26	11165229
The rat H3 receptor: gene organization and multiple isoforms.	2001-01-12	11162480
Questions regarding future research on aspirin and the gastrointestinal tract.	2001-01-08	11166004
Prospects for changing the burden of nonsteroidal anti-inflammatory drug toxicity.	2001-01-08	11165994
Approaches to healing and prophylaxis of nonsteroidal anti-inflammatory drug-associated ulcers.	2001-01-08	11165992
Comparison of montelukast and fexofenadine for chronic idiopathic urticaria.	2001-01	11176678
Preclinical profile of the monodisperse iodinated macromolecular blood pool agent P743.	2001-01	11176260
The dyspepsia alphabet: DU, GU, GERD, NERD, NUD/FD and UD.	2001-01	11173326
Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis.	2001-01	11167952
Combination therapy with anti-mediator drugs in allergic disease.	2001-01	11167945
Urticaria induced by cetirizine.	2001-01	11167712
Interleukin-4-positive mast cells are highly associated with the extent of immediate allergic wheal reaction in the skin.	2001-01	11167353
A randomized, double-blind, crossover comparison among cetirizine, levocetirizine, and ucb 28557 on histamine-induced cutaneous responses in healthy adult volunteers.	2001-01	11167352
Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma.	2001-01	11167350
The treatment of rhinovirus infections: progress and potential.	2001-01	11166856
Effect of acute metabolic acid/base shifts on the human airway calibre.	2001-01	11164206
Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp.	2001-01	11163599
Mediator involvement in antigen-induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats.	2001-01	11159698
Inhibition by glucocorticoids of the mast cell-dependent weal and flare response in human skin in vivo.	2001-01	11156588

Patents

Sample Use Guides

In Vivo Use Guide

The skin in the test area should be cleansed with alcohol and air dried. The histamine control skin test solution should be placed at the same site with the other skin test antigens, either on the patient's back or on the volar surface of the forearm. The patient should be placed in a comfortable position before the testing is begun. For the prick test, a sharp needle is used to puncture the skin, but not to draw blood. If the scratch test is used, carefully break or scratch the skin with a sterile scarifier. Do not draw blood. Each scratch should be about 2 mm - 4 mm in length. A small drop of the histamine base 1 mg/mL (Histamine Phosphate 2.75 mg/mL) is placed on the abraded skin site no closer than 4 or 5 cm from an adjacent test site. Some physicians prefer to place the solution on the test area and then prick through the drop with a sharp needle.

Route of Administration: Parenteral

In Vitro Use Guide

Histamine prevented monocytic apoptosis induced by serum deprivation, CD95/Fas ligation, or dexamethasone in a dose- and time-dependent fashion. The inhibitory effects of histamine on monocytic apoptosis were blocked by an H2R antagonist, and mimicked by an H2R agonist. Histamine also up-regulated the expression of Bcl-2 and Mcl-1, and inhibited the activation of caspase-3. The culture supernatants from histamine-treated monocytes inhibited monocytic apoptosis, which was partly reversed by the removal of IL-10. Monocytes cultured with anti-IL-10 mAb and histamine did not exhibit an inhibitory effect on apoptosis. The histamine-induced anti-apoptotic effect was attenuated when monocytes were cultured in the presence of a cAMP inhibitor.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:49:15 GMT 2025` Edited by `admin` on `Mon Mar 31 17:49:15 GMT 2025`
Record UNII	820484N8I3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NSC-33792

Preferred Name

English

HISTAMINE

Systematic Name

English

ERGOTIDINE

Common Name

English

ERGAMINE

Common Name

English

Histamine [WHO-DD]

Common Name

English

HISTAMINE [MI]

Common Name

English

5-IMIDAZOLEETHYLAMINE

Systematic Name

English

HISTAMINE [MART.]

Common Name

English

1H-IMIDAZOLE-4-ETHANAMINE

Systematic Name

English

HISTAMINE [VANDF]

Common Name

English

.BETA.-AMINOETHYLGLYOXALINE

Common Name

English

4-IMIDAZOLEETHYLAMINE

Systematic Name

English

.BETA.-AMINOETHYLIMIDAZOLE

Systematic Name

English

2-(4-IMIDAZOLYL)ETHYLAMINE

Systematic Name

English

HISTAMINE [HSDB]

Common Name

English

Classification Tree Code System Code

LOINC

34316-0

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

LOINC

33290-8

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LOINC

25439-1

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LOINC

2417-4

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LOINC

34317-8

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NCI_THESAURUS

C687

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FDA ORPHAN DRUG

127199

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LOINC

2416-6

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FDA ORPHAN DRUG

127399

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LOINC

13755-4

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LOINC

13756-2

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LOINC

9410-2

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LOINC

2415-8

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LOINC

25925-9

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WHO-ATC

L03AX14

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NCI_THESAURUS

C2139

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LOINC

35260-9

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LOINC

43577-6

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LOINC

44371-3

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Code System Code Type Description

NCI_THESAURUS

C73238

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

PRIMARY

NSC

33792

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

PRIMARY

FDA UNII

820484N8I3

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

PRIMARY

DRUG BANK

DB05381

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

PRIMARY

ECHA (EC/EINECS)

200-100-6

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

PRIMARY

CAS

51-45-6

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

PRIMARY

WIKIPEDIA

HISTAMINE

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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MESH

D006632

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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DRUG CENTRAL

1375

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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MERCK INDEX

m6026

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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Merck Index

PUBCHEM

774

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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CHEBI

18295

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

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CHEBI

58432

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

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EPA CompTox

DTXSID4023125

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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HSDB

3338

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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SMS_ID

100000089506

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

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DAILYMED

820484N8I3

Created by admin on Mon Mar 31 17:49:16 GMT 2025 , Edited by admin on Mon Mar 31 17:49:16 GMT 2025

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RXCUI

5333

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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RxNorm

EVMPD

SUB14107MIG

Created by admin on Mon Mar 31 17:49:15 GMT 2025 , Edited by admin on Mon Mar 31 17:49:15 GMT 2025

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Related Record Type Details


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> AGONIST

Qualification:

IC50

Amount:


					3POA0Q644U

HISTAMINE DIHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:


					ONY583280Z

OCT-1

TRANSPORTER -> SUBSTRATE

Amount:


					QWB37T4WZZ

HISTAMINE PHOSPHATE

SALT/SOLVATE -> PARENT

Amount:


					CAU4JAJ646

Histamine N-methyltransferase

METABOLIC ENZYME -> SUBSTRATE

Amount:


					4007E25Z4Z

OCT-3

TRANSPORTER -> INHIBITOR


					28XBT591QG

HISTAMINE H1 RECEPTOR

TARGET -> AGONIST

Comments:

CHO-H1 cells, histamine stimulation resulted in a concentration-dependent increase in [Ca2+]i with an EC50 of 170±30 nM.

Qualification:

EC50

Amount:


					F9I23AC4PQ

HISTAMINE MONOHYDROCHLORIDE

SALT/SOLVATE -> PARENT

Amount:

Related Record Type Details


					EKP351892F

N-METHYLIMIDAZOLEACETIC ACID

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:


					KCB81T4EOF

1-METHYLHISTAMINE

METABOLITE INACTIVE -> PARENT

Amount:


					B4S3Z68DDD

Imidazole acetylaldehyde

METABOLITE INACTIVE -> PARENT

Amount:


					IGZ30Z24EJ

IMIDAZOLEACETIC ACID

METABOLITE INACTIVE -> PARENT

Interaction Type:

MAJOR

Amount:

Related Record Type Details


					820484N8I3

HISTAMINE

ACTIVE MOIETY

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/26084539 | https://www.drugs.com/pro/histamine-phosphate.html | https://www.drugs.com/mmx/histamine-phosphate.html

CNS Activity

Originator

Approval Year

Targets

Conditions

Approved Use

Launch Date

Approved Use

Approved Use

Launch Date

Cmax

AUC

T1/2

Doses

Overview

OverviewOther

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26084539 | https://www.drugs.com/pro/histamine-phosphate.html | https://www.drugs.com/mmx/histamine-phosphate.html

C_max

T_1/2