PROTHROMBIN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

US Approved Rx (2013)

First approved in 2013

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:32:30 GMT 2025` Edited by `admin` on `Mon Mar 31 20:32:30 GMT 2025`
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	8FB1K07F16
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

PROTHROMBIN

Common Name

English

COAGULATION FACTOR II (HUMAN)

Preferred Name

English

COAGULATION FACTOR II HUMAN

Common Name

English

Factor ii (prothrombin) [WHO-DD]

Common Name

English

PROTHROMBIN [MI]

Common Name

English

HUMAN COAGULATION FACTOR II

Common Name

English

FACTOR II

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

305310

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

NCI_THESAURUS

C78311

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

FDA ORPHAN DRUG

225806

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

NDF-RT

N0000184168

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

Code System Code Type Description

MERCK INDEX

m9269

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

FDA UNII

8FB1K07F16

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

DAILYMED

8FB1K07F16

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

SMS_ID

100000130058

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

NCI_THESAURUS

C82273

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

NDF-RT

N0000007914

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

Blood Coagulation Factors [Chemical/Ingredient]

NDF-RT

N0000175979

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

Increased Coagulation Activity [PE]

EVMPD

SUB13807MIG

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

CAS

9001-26-7

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

EVMPD

SUB41201

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

UNIPROT

P00734

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

DRUG BANK

DB11311

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

RXCUI

1441688

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

RxNorm

MESH

D011516

Created by admin on Mon Mar 31 20:32:30 GMT 2025 , Edited by admin on Mon Mar 31 20:32:30 GMT 2025

PRIMARY

From	To
1_17	1_22
1_47	1_60
1_65	1_143
1_86	1_126
1_170	1_248
1_191	1_231
1_219	1_243
1_293	1_439
1_348	1_364
1_493	1_507
1_521	1_551
1_114	1_138

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_78
N	1_100
N	1_373

Related Record Type Details


					TN9BEX005G

INHIBITOR -> TARGET


					W1DT53SAN0

TARGET -> SUBSTRATE


					I0VM4M70GC

INHIBITOR -> TARGET

Amount:

Related Record Type Details


					8FB1K07F16

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_6] [1_7] [1_14] [1_16] [1_19] [1_20] [1_25] [1_26] [1_29] [1_32]	SITE_SPECIFIC			.GAMMA.-CARBOXYGLUTAMIC ACID	16FQV4RZKL

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL