Solriamfetol

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NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H14N2O2
Molecular Weight	194.2304
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of Solriamfetol

Structure Search

SMILES

N[C@@H](COC(N)=O)CC1=CC=CC=C1

InChI

InChIKey=UCTRAOBQFUDCSR-SECBINFHSA-N

InChI=1S/C10H14N2O2/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8/h1-5,9H,6-7,11H2,(H2,12,13)/t9-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H14N2O2
Molecular Weight	194.2304
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:21:08 UTC 2023` Edited by `admin` on `Sat Dec 16 08:21:08 UTC 2023`
Record UNII	939U7C91AI
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Solriamfetol

Official Name

English

(2R)-2-Amino-3-phenylpropyl carbamate

Systematic Name

English

Solriamfetol [WHO-DD]

Common Name

English

SOLRIAMFETOL [ORANGE BOOK]

Common Name

English

YKP-10A

Code

English

R-228060

Code

English

SUNOSI

Brand Name

English

Benzenepropanol, β-amino-, 1-carbamate, (βR)-

Systematic Name

English

JZP-110

Code

English

solriamfetol [INN]

Common Name

English

Benzenepropanol, β-amino-, carbamate (ester), (βR)-

Systematic Name

English

ADX-N-05

Code

English

SKL-N-05

Code

English

SOLRIAMFETOL [USAN]

Common Name

English

SOLRIAMFETOL [MI]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78272

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

Code System Code Type Description

INN

10117

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

DRUG CENTRAL

5325

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

RXCUI

2121751

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

MERCK INDEX

m12132

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

SMS_ID

100000180153

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

FDA UNII

939U7C91AI

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

EPA CompTox

DTXSID401027926

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

CAS

178429-62-4

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

WIKIPEDIA

Solriamfetol

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

PUBCHEM

10130337

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

DRUG BANK

DB14754

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

USAN

EF-113

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

DAILYMED

939U7C91AI

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

NCI_THESAURUS

C152389

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

LACTMED

Solriamfetol

Created by admin on Sat Dec 16 08:21:09 UTC 2023 , Edited by admin on Sat Dec 16 08:21:09 UTC 2023

PRIMARY

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Solriamfetol Hydrochloride

SALT/SOLVATE -> PARENT

Amount:


					482M00274D

OCT-2

TRANSPORTER -> INHIBITOR

Interaction Type:

WEAK

Qualification:

IC50

Amount:


					JU9DSW3H7E

Solriamfetol, (±)-

RACEMATE -> ENANTIOMER

Amount:


					6NP3XSMIP3

MULTIDRUG AND TOXIN EXTRUSION PROTEIN 1

TRANSPORTER -> INHIBITOR

Interaction Type:

WEAK

Qualification:

IC50

Amount:


					6D53G0FD0Z

PLASMA PROTEIN FRACTION (HUMAN)

BINDER->LIGAND

Interaction Type:

BINDING

Amount:


					939U7C91AI

EXCRETED UNCHANGED

Comments:

Approximately 95% of the dose was recovered in urine as unchanged solriamfetol, 1% or less of the administered dose was recovered in urine as the minor inactive metabolite N-acetyl solriamfetol.

Qualification:

URINE

Amount:


					F202H3PMO2

SODIUM-DEPENDENT DOPAMINE TRANSPORTER

TARGET -> INHIBITOR

Qualification:

Ki

Amount:


					HN86OLH1NW

SODIUM-DEPENDENT NORADRENALINE TRANSPORTER

TARGET -> INHIBITOR

Qualification:

Ki

Amount:

Related Record Type Details


					0NND6AYK6R

N-ACETYL SOLRIAMFETOL

METABOLITE INACTIVE -> PARENT

Amount:


					A6QY3U3O3V

PHENYLALANINOL, D-

METABOLITE -> PARENT

Amount:


					3DRR664NYZ

((2R)-2-AMINO-3-(4-HYDROXYPHENYL)PROPYL) CARBAMATE

METABOLITE -> PARENT

Amount:

Related Record Type Details


					939U7C91AI

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Volume of Distribution	PHARMACOKINETIC

Biological Half-life	PHARMACOKINETIC

ORAL BIOAVAILABILITY	PHARMACOKINETIC

Tmax	PHARMACOKINETIC