U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Mon Mar 31 21:54:11 GMT 2025
Edited
by admin
on Mon Mar 31 21:54:11 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
482M00274D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OCT-2
Common Name English
OCT2
Preferred Name English
ORGANIC CATION TRANSPORTER 2
Common Name English
SLC22A2
Common Name English
SOLUTE CARRIER FAMILY 22 MEMBER 2
Common Name English
Classification Tree Code System Code
UCSF-FDA TRANSPORTAL SLC22A2
Created by admin on Mon Mar 31 21:54:11 GMT 2025 , Edited by admin on Mon Mar 31 21:54:11 GMT 2025
Code System Code Type Description
FDA UNII
482M00274D
Created by admin on Mon Mar 31 21:54:11 GMT 2025 , Edited by admin on Mon Mar 31 21:54:11 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_72
Related Record Type Details
Structure of IMATINIB
SUBSTRATE -> TRANSPORTER
Structure of RIBOCICLIB
INHIBITOR -> TRANSPORTER
Structure of FLURAZEPAM
INHIBITOR -> TRANSPORTER
Structure of SEPANTRONIUM BROMIDE
INHIBITOR -> TRANSPORTER
Structure of Desloratadine
INHIBITOR -> TRANSPORTER
Structure of PANOBINOSTAT
INHIBITOR -> TRANSPORTER
Structure of PONATINIB
NON-SUBSTRATE -> TRANSPORTER
Structure of DASATINIB
INHIBITOR -> TRANSPORTER
Structure of SUNITINIB
INHIBITOR -> TRANSPORTER
Structure of Olaparib
INHIBITOR -> TRANSPORTER
Structure of DIPHENHYDRAMINE
INHIBITOR -> TRANSPORTER
Structure of MEXILETINE
INHIBITOR -> TRANSPORTER
Structure of TETRAPENTYLAMMONIUM
INHIBITOR -> TRANSPORTER
Structure of ATROPINE
INHIBITOR -> TRANSPORTER
Structure of CARVEDILOL
INHIBITOR -> TRANSPORTER
Structure of IMIPRAMINE
INHIBITOR -> TRANSPORTER
Structure of TETRAETHYLAMMONIUM
INHIBITOR -> TRANSPORTER
Structure of GEFITINIB
SUBSTRATE -> TRANSPORTER
Structure of TAMOXIFEN
INHIBITOR -> TRANSPORTER
Structure of BRANEBRUTINIB
INHIBITOR -> TRANSPORTER
Structure of KETAMINE
INHIBITOR -> TRANSPORTER
Structure of FENFLURAMINE
INHIBITOR -> TRANSPORTER
Structure of AMANTADINE
SUBSTRATE -> TRANSPORTER
Structure of CLONIDINE
INHIBITOR -> TRANSPORTER
Structure of VANDETANIB
INHIBITOR -> TRANSPORTER
Structure of ERLOTINIB
SUBSTRATE -> TRANSPORTER
Structure of METHAMPHETAMINE
INHIBITOR -> TRANSPORTER
IC50
Structure of CIMETIDINE
SUBSTRATE -> TRANSPORTER
Structure of TAFENOQUINE
INHIBITOR -> TRANSPORTER
corrected for non-specific binding
IC50
Structure of CREATININE
SUBSTRATE -> TRANSPORTER
Structure of Solriamfetol
INHIBITOR -> TRANSPORTER
WEAK
IC50
Structure of MEMANTINE
SUBSTRATE -> TRANSPORTER
Structure of GILTERITINIB
INHIBITOR -> TRANSPORTER
WEAK
IC50
Structure of Nilotinib
SUBSTRATE -> TRANSPORTER
Structure of Bictegravir
INHIBITOR -> TRANSPORTER
Co?administration of BIKTARVY with dofetilide may increase dofetilide plasma concentrations which can lead to serious and/or life threatening events.
IC50
Structure of IPTACOPAN
NON-SUBSTRATE -> TRANSPORTER
Structure of TRIMETHOPRIM
INHIBITOR -> TRANSPORTER
Structure of ERLOTINIB
INHIBITOR -> TRANSPORTER
Structure of MIDOMAFETAMINE
INHIBITOR -> TRANSPORTER
Structure of Amitriptyline
INHIBITOR -> TRANSPORTER
Structure of QUININE
INHIBITOR -> TRANSPORTER
Structure of Ipratropium bromide
INHIBITOR -> TRANSPORTER
Structure of COCAINE
INHIBITOR -> TRANSPORTER
Structure of COBICISTAT
INHIBITOR -> TRANSPORTER
Structure of CHLOROQUINE
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
INHIBITOR -> TRANSPORTER
Structure of DESIPRAMINE
INHIBITOR -> TRANSPORTER
Structure of PYRIDINE
INHIBITOR -> TRANSPORTER
Structure of CIMETIDINE
INHIBITOR -> TRANSPORTER
Structure of GEFITINIB
INHIBITOR -> TRANSPORTER
Structure of 1-Hexylpyridinium chloride
INHIBITOR -> TRANSPORTER
Structure of CORTICOSTERONE
INHIBITOR -> TRANSPORTER
Structure of ABAMETAPIR
INHIBITOR -> TRANSPORTER
but the ratio of the unbound Cmax to the IC50 is less than 0.1
IC50
Structure of RANITIDINE
INHIBITOR -> TRANSPORTER
Structure of IMEGLIMIN
SUBSTRATE -> TRANSPORTER
Structure of AMANTADINE
INHIBITOR -> TRANSPORTER
Structure of 1-BUTYL-1-METHYLPYRROLIDINIUM CHLORIDE
INHIBITOR -> TRANSPORTER
Structure of MEFLOQUINE
INHIBITOR -> TRANSPORTER
Structure of DIZOCILPINE
INHIBITOR -> TRANSPORTER
Structure of PHENCYCLIDINE
INHIBITOR -> TRANSPORTER
Structure of FLECAINIDE
INHIBITOR -> TRANSPORTER
Structure of GREPAFLOXACIN
INHIBITOR -> TRANSPORTER
Structure of PRAZOSIN
INHIBITOR -> TRANSPORTER
Structure of DASATINIB
SUBSTRATE -> TRANSPORTER
Structure of PHENFORMIN
INHIBITOR -> TRANSPORTER
Structure of Binimetinib
INHIBITOR -> TRANSPORTER
MINOR
IC50
Structure of 1-ETHYLPYRIDINIUM CHLORIDE
INHIBITOR -> TRANSPORTER
Structure of IMATINIB
INHIBITOR -> TRANSPORTER
Structure of PHENOXYBENZAMINE
INHIBITOR -> TRANSPORTER
Structure of FURAMIDINE
INHIBITOR -> TRANSPORTER
Structure of PENTAMIDINE
INHIBITOR -> TRANSPORTER
Structure of BMS-986299
INHIBITOR -> TRANSPORTER
Structure of ABAMETAPIR CARBOXYL
INHIBITOR -> TRANSPORTER
Structure of DISOPYRAMIDE
INHIBITOR -> TRANSPORTER
Structure of PSEUDOISOCYANINE IODIDE
INHIBITOR -> TRANSPORTER
Structure of SIBUTRAMINE
INHIBITOR -> TRANSPORTER
Structure of VERAPAMIL
INHIBITOR -> TRANSPORTER
Structure of PROPAFENONE
INHIBITOR -> TRANSPORTER
Structure of PROPRANOLOL
INHIBITOR -> TRANSPORTER
Structure of MEPIPERPHENIDOL
INHIBITOR -> TRANSPORTER
Structure of Metformin
SUBSTRATE -> TRANSPORTER
Structure of CETIRIZINE
INHIBITOR -> TRANSPORTER
Structure of LEVOMETHADONE
INHIBITOR -> TRANSPORTER
Structure of FEDRATINIB
INHIBITOR -> TRANSPORTER
IC50
Structure of PILSICAINIDE
INHIBITOR -> TRANSPORTER
Structure of DEXTROAMPHETAMINE
INHIBITOR -> TRANSPORTER
Structure of OXALIPLATIN
SUBSTRATE -> TRANSPORTER
Structure of QUINIDINE
INHIBITOR -> TRANSPORTER
Structure of ENCORAFENIB
INHIBITOR -> TRANSPORTER
IC50
Structure of BUTYLSCOPOLAMINE
INHIBITOR -> TRANSPORTER
Structure of Teriflunomide
INHIBITOR -> TRANSPORTER
Terifluniomide is an inhibitor of BCRP, OAT3, OATP1B1, OCT2 in vitro
Structure of BUTYLMETHYLIMIDAZOLIUM CHLORIDE
INHIBITOR -> TRANSPORTER
Structure of N-BUTYLPYRIDINIUM CHLORIDE
INHIBITOR -> TRANSPORTER
Structure of FAMOTIDINE
INHIBITOR -> TRANSPORTER
DOXEPIN
INHIBITOR -> TRANSPORTER
Structure of METHAMPHETAMINE
SUBSTRATE -> TRANSPORTER
Structure of MEMANTINE
INHIBITOR -> TRANSPORTER
Structure of CHLORPROMAZINE
INHIBITOR -> TRANSPORTER
Structure of AMPHETAMINE
SUBSTRATE -> TRANSPORTER
Structure of TESTOSTERONE
INHIBITOR -> TRANSPORTER
Structure of Tirbanibulin
INHIBITOR -> TRANSPORTER
The results suggest that KLISYRI has no clinically meaningful effect on the PK of drugs mediated by OCT2
IC50
Structure of DX-619
INHIBITOR -> TRANSPORTER
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
NIH
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