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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H18ClN3O5S
Molecular Weight 435.881
Optical Activity ( - )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RIVAROXABAN

SMILES

ClC1=CC=C(S1)C(=O)NC[C@H]2CN(C(=O)O2)C3=CC=C(C=C3)N4CCOCC4=O

InChI

InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N
InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1

HIDE SMILES / InChI
Molecular Formula C19H18ClN3O5S
Molecular Weight 435.881
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Unknown
86413
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:28 UTC 2023
Edited
by admin
on Fri Dec 15 15:52:28 UTC 2023
Record UNII
9NDF7JZ4M3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RIVAROXABAN
DASH   EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
Rivaroxaban [WHO-DD]
Common Name English
RIVAROXABAN [EMA EPAR]
Common Name English
JNJ-39039039
Code English
RIVAROXABAN [ORANGE BOOK]
Common Name English
RIVAROXABAN [MI]
Common Name English
RIVAROXABAN [USP-RS]
Common Name English
rivaroxaban [INN]
Common Name English
RIVAROXABAN [MART.]
Common Name English
2-THIOPHENECARBOXAMIDE, 5-CHLORO-N-(((5S)-2-OXO-3-(4-(3-OXO-4-MORPHOLINYL)PHENYL)-5-OXAZOLIDINYL)METHYL)-
Systematic Name English
RIVAROXABAN [VANDF]
Common Name English
JNJ39039039
Code English
RIVAROXABAN [JAN]
Common Name English
BAY 59-7939
Code English
RIVAROXABAN [USAN]
Common Name English
RIVAROXABAN [EP MONOGRAPH]
Common Name English
XARELTO
Brand Name English
5-Chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide
Systematic Name English
BAY-59-7939
Code English
Classification Tree Code System Code
EMA ASSESSMENT REPORTS XARELTO (AUTHORIZED: ARTHROPLASTY, REPLACEMENT)
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
NCI_THESAURUS C263
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
WHO-ATC B01AF01
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
NDF-RT N0000175637
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
EMA ASSESSMENT REPORTS XARELTO (AUTHORIZED: VENOUS THROMBOEMBOLISM)
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
WHO-ATC B01AX06
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
WHO-VATC QB01AF01
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
LIVERTOX NBK548015
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
LOINC 74871-5
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID3057723
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
NCI_THESAURUS
C77995
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
DRUG BANK
DB06228
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
MERCK INDEX
m9638
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY Merck Index
DAILYMED
9NDF7JZ4M3
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
WIKIPEDIA
RIVAROXABAN
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
FDA UNII
9NDF7JZ4M3
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
INN
8428
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
IUPHAR
6388
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
USAN
SS-99
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
ChEMBL
CHEMBL198362
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
RXCUI
1114195
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY RxNorm
CAS
366789-02-8
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
DRUG CENTRAL
4182
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
MESH
C503223
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
PUBCHEM
9875401
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
SMS_ID
100000092811
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
LACTMED
Rivaroxaban
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
RS_ITEM_NUM
1604530
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
HSDB
8149
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
EVMPD
SUB29263
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
CHEBI
68579
Created by admin on Fri Dec 15 15:52:29 UTC 2023 , Edited by admin on Fri Dec 15 15:52:29 UTC 2023
PRIMARY
Related Record Type Details
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METABOLIC ENZYME -> SUBSTRATE
COAGULATION FACTOR X HUMAN
TARGET -> INHIBITOR
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COAGULATION FACTOR X HUMAN
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METABOLIC ENZYME -> SUBSTRATE
ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2
TRANSPORTER -> SUBSTRATE
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BINDER->LIGAND
BINDING
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TARGET -> INHIBITOR
MULTIDRUG RESISTANCE PROTEIN 1
TRANSPORTER -> SUBSTRATE
Related Record Type Details
Structure of 2-HYDROXY-3-OXO-RIVAROXABAN
METABOLITE -> PARENT
MINOR
FECAL; URINE
Structure of N-((5-CHLORO-2-THIENYL)CARBONYL)GLYCINE
METABOLITE -> PARENT
IN-VITRO
FECAL; URINE
Structure of 5-CHLORO-N-(((5S)-3-(4-((2-HYDROXYETHYL)AMINO)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-2-THIOPHENECARBOXAMIDE
METABOLITE -> PARENT
MINOR
FECAL; URINE
Structure of 2-HYDROXY-5-OXO-RIVAROXABAN
METABOLITE -> PARENT
Structure of RIVAROXABAN DIOL
METABOLITE -> PARENT
excreta 2.5% radio acitivty
Structure of 2-((4-((5S)-5-((((5-CHLORO-2-THIENYL)CARBONYL)AMINO)METHYL)-2-OXO-3-OXAZOLIDINYL)PHENYL)(2-HYDROXYETHYL)AMINO)-2-OXO-ACETIC ACID
METABOLITE -> PARENT
IN-VIVO
FECAL; URINE
Structure of 2-HYDROXY-3-OXO-RIVAROXABAN
METABOLITE -> PARENT
Related Record Type Details
Structure of N,N'-BIS(DES(5-CHLORO-2-CARVOXYTHIENYL) RIVAROXABAN) UREA
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 4-CHLORORIVAROXABAN
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of N-(((5S)-2-OXO-3-(4-(3-OXO-4-MORPHOLINYL)PHENYL)-5-OXAZOLIDINYL)METHYL)ACETAMIDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of RIVAROXABAN PSEUDODIMER
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 1H-ISOINDOLE-1,3(2H)-DIONE, 2-(((5S)-2-OXO-3-(4-(3-OXO-4-MORPHOLINYL)PHENYL)-5-OXAZOLIDINYL)METHYL)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of 3-MORPHOLINONE, 4-(4-(5-(((1,1-DIMETHYL-3-OXOBUTYL)AMINO)METHYL)-2-OXO-3-OXAZOLIDINYL)PHENYL), (S)-
IMPURITY -> PARENT
Structure of 5-CHLORO-2-THIOPHENECARBOXYLIC ACID
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of Hydrochloric acid
IMPURITY -> PARENT
Structure of 2-THIOPHENECARBOXAMIDE, 5-CHLORO-N-(1,1-DIMETHYL-3-OXOBUTYL)-N-((2-OXO-3-(4-(3-OXO-4-MORPHOLINYL)PHENYL)-5-OXAZOLIDINYL)METHYL), (S)-
IMPURITY -> PARENT
Structure of DECHLORO-RIVAROXABAN
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of RIVAROXABAN, (R)-
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Structure of RIVAROXABAN N-HYDROLYSE N-5-CHLOROTHIOPHENE-2-CARBALDEHYDE
IMPURITY -> PARENT
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
Related Record Type Details
Structure of RIVAROXABAN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
NIH
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