ISOCITRATE DEHYDROGENASE (NADP) CYTOPLASMIC R132H

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 02:11:23 GMT 2025` Edited by `admin` on `Wed Apr 02 02:11:23 GMT 2025`
Protein Type	ENZYME
Protein Sub Type	OXIDOREDUCTASE
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	9STQ04T9G6
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IDH R132H MUTANT

Preferred Name

English

ISOCITRATE DEHYDROGENASE (NADP) CYTOPLASMIC R132H

Common Name

English

NADP(+)-SPECIFIC ICDH R132H

Common Name

English

OXALOSUCCINATE DECARBOXYLASE R132H

Common Name

English

PICD R132H

Common Name

English

IDH1 R132H MUTANT

Common Name

English

CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE R132H

Common Name

English

Code System Code Type Description

FDA UNII

9STQ04T9G6

Created by admin on Wed Apr 02 02:11:23 GMT 2025 , Edited by admin on Wed Apr 02 02:11:23 GMT 2025

PRIMARY

EC (ENZYME CLASS)

EC 1.1.1.42

Created by admin on Wed Apr 02 02:11:23 GMT 2025 , Edited by admin on Wed Apr 02 02:11:23 GMT 2025

PRIMARY

WIKIPEDIA

IDH1

Created by admin on Wed Apr 02 02:11:23 GMT 2025 , Edited by admin on Wed Apr 02 02:11:23 GMT 2025

PRIMARY

UNIPROT

O75874

Created by admin on Wed Apr 02 02:11:23 GMT 2025 , Edited by admin on Wed Apr 02 02:11:23 GMT 2025

PRIMARY

Related Record Type Details


					Q2PCN8MAM6

IVOSIDENIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:


					0T4IMT8S5Z

OLUTASIDENIB

INHIBITOR -> TARGET

Qualification:

IC50

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID REPLACEMENT	[1_388] [2_388]		SERINE	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID REPLACEMENT	[1_1] [2_1]		SERINE	N-ACETYLSERINE	W98518XGZ3
AMINO ACID REPLACEMENT	[1_125] [1_399] [2_125] [2_399]		LYSINE	N6-SUCCINYLLYSINE	3LH35AJA5L
METAL_BINDING	[1_251] [1_274] [1_278] [2_251] [2_274] [2_278]	SITE_SPECIFIC		MAGNESIUM CATION	T6V3LHY838
AMINO ACID REPLACEMENT	[1_41] [2_41]		TYROSINE	TYROSINE O-PHOSPHATE	2R86C98KDX
METAL_BINDING	[1_251] [1_274] [1_278] [2_251] [2_274] [2_278]	SITE_SPECIFIC		MANGANOUS CATION	H6EP7W5457
AMINO ACID REPLACEMENT	[1_80] [1_223] [1_232] [1_242] [1_320] [2_80] [2_223] [2_232] [2_242] [2_320]		LYSINE	N6-ACETYLLYSINE	470AD5VY1X

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED)	CHEMICAL