Cliramitug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 18:15:37 GMT 2025` Edited by `admin` on `Wed Apr 02 18:15:37 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	DF9B2M6KQG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Cliramitug

Common Name

English

ALXN-2220

Preferred Name

English

Immunoglobulin G1, anti-(human amyloid transthyretin) (human monoclonal ALXN2220 ?1-chain), disulfide with human monoclonal ALXN2220 ?-chain, dimer

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TTR (transthyretin) amyloid], Homo sapiens monoclonal antibody; H-gamma1 heavy chain Homo sapiens (1-450) [VH (Homo sapiens IGHV4-39*01 (87.9%) -(IGHD) -IGHJ3*02 (100%), CDRIMGT [10.7.12](26-35.53-59.98-109)) (

Common Name

English

cliramitug [INN]

Common Name

English

Code System Code Type Description

INN

13403

Created by admin on Wed Apr 02 18:15:37 GMT 2025 , Edited by admin on Wed Apr 02 18:15:37 GMT 2025

PRIMARY

CAS

2965214-50-8

Created by admin on Wed Apr 02 18:15:37 GMT 2025 , Edited by admin on Wed Apr 02 18:15:37 GMT 2025

PRIMARY

FDA UNII

DF9B2M6KQG

Created by admin on Wed Apr 02 18:15:37 GMT 2025 , Edited by admin on Wed Apr 02 18:15:37 GMT 2025

PRIMARY

From	To
1_22	1_97
2_22	2_97
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					2COU0B578R

TRANSTHYRETIN

TARGET->LIGAND

Amount:

Related Record Type Details


					DF9B2M6KQG

Cliramitug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS	K		LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL