Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C36H36N4O4 |
| Molecular Weight | 588.6954 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN(CC1=CC=CC=C1)C(=O)[C@H](CC2=CC=C3C=CC=CC3=C2)NC(=O)[C@@H]4C[C@@H](O)CN4C(=O)C5=CN(C)C6=C5C=CC=C6
InChI
InChIKey=BFNKQTIJVFGCKQ-PDJGWCFMSA-N
InChI=1S/C36H36N4O4/c1-38-23-30(29-14-8-9-15-32(29)38)35(43)40-22-28(41)20-33(40)34(42)37-31(36(44)39(2)21-24-10-4-3-5-11-24)19-25-16-17-26-12-6-7-13-27(26)18-25/h3-18,23,28,31,33,41H,19-22H2,1-2H3,(H,37,42)/t28-,31+,33+/m1/s1
| Molecular Formula | C36H36N4O4 |
| Molecular Weight | 588.6954 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Efficient synthesis of a small molecule, nonpeptide inhibitor of LFA-1. | 2010-10-01 |
|
| Complete genome sequence of Marinobacter adhaerens type strain (HP15), a diatom-interacting marine microorganism. | 2010-09-28 |
|
| Ochrobactrum ciceri sp. nov., isolated from nodules of Cicer arietinum. | 2010-07 |
|
| Synthesis of novel MMT/acyl-protected nucleo alanine monomers for the preparation of DNA/alanyl-PNA chimeras. | 2010-05 |
|
| Complete genome sequence of Gordonia bronchialis type strain (3410). | 2010-01-28 |
|
| Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. | 2009-08 |
|
| Distributed Drug Discovery, Part 2: global rehearsal of alkylating agents for the synthesis of resin-bound unnatural amino acids and virtual D(3) catalog construction. | 2008-12-25 |
|
| Sugar-driven prebiotic synthesis of 3,5(6)-dimethylpyrazin-2-one: a possible nucleobase of a primitive replication process. | 2008-08 |
|
| Pseudoxanthobacter soli gen. nov., sp. nov., a nitrogen-fixing alphaproteobacterium isolated from soil. | 2008-07 |
|
| Complexes of Cu(II) ions and noncovalent interactions in systems with L-aspartic acid and cytidine-5'-monophosphate. | 2008 |
|
| Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats. | 2007-09 |
|
| Bacillus decisifrondis sp. nov., isolated from soil underlying decaying leaf foliage. | 2007-05 |
|
| Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs. | 2006-12-01 |
|
| Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema. | 2006-08 |
|
| Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors. | 2006-07-15 |
|
| [The effect of betulonic acid and its alanine amide derivatives on rat liver parenchyma repair during postcytostatic period]. | 2006-01-13 |
|
| Purification, characterization, gene cloning and nucleotide sequencing of D: -stereospecific amino acid amidase from soil bacterium: Delftia acidovorans. | 2005-12 |
|
| Application of Fourier transform infrared spectroscopy for monitoring hydrolysis and synthesis reactions catalyzed by a recombinant amidase. | 2005-11-01 |
|
| Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice. | 2005-09 |
|
| Effect of betulonic acid and its derivative [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid on liver structure in mice with RLS lymphoma. | 2005-09 |
|
| Single peptide bonds exhibit poly(pro)II ("random coil") circular dichroism spectra. | 2005-07-13 |
|
| Ion transfer at nanointerfaces between water and neat organic solvents. | 2005-06-22 |
|
| Visual enantiomeric recognition of amino acid derivatives in protic solvents. | 2005-06-10 |
|
| Dynamic kinetic resolution of amino acid amide catalyzed by D-aminopeptidase and alpha-amino-epsilon-caprolactam racemase. | 2005-06-01 |
|
| A DmpA-homologous protein from Pseudomonas sp. is a dipeptidase specific for beta-alanyl dipeptides. | 2005-06 |
|
| Quantitation of 3-aminopropionamide in potatoes-a minor but potent precursor in acrylamide formation. | 2004-07-28 |
|
| Simple, short peptide derivatives of a sulfonylindolecarboxamide (L-737,126) active in vitro against HIV-1 wild type and variants carrying non-nucleoside reverse transcriptase inhibitor resistance mutations. | 2004-07-15 |
|
| S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase. | 2004-04 |
|
| Design of chiral monochloro-s-triazine reagents for the liquid chromatographic separation of amino acid enantiomers. | 2003-05-23 |
|
| Chemically modified "polar patch" mutants of subtilisin in peptide synthesis with remarkably broad substrate acceptance: designing combinatorial biocatalysts. | 2002-09-16 |
|
| Effect of YM-44781, YM-44778 and YM-49598, novel tachykinin antagonists, in a drug-induced bladder contraction model. | 2002-05 |
|
| Chemically modified chiral monolithic silica column prepared by a sol-gel process for enantiomeric separation by micro high-performance liquid chromatography. | 2002-01-04 |
|
| Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice. | 1997-08 |
|
| A neurokinin 1-receptor antagonist improves exercise-induced airway narrowing in asthmatic patients. | 1996-03 |
|
| 'Sensory-efferent' neural control of mucus secretion: characterization using tachykinin receptor antagonists in ferret trachea in vitro. | 1994-12 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 06:43:47 GMT 2025
by
admin
on
Wed Apr 02 06:43:47 GMT 2025
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| Record UNII |
DZQ7B7BPD4
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID70160680
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DZQ7B7BPD4
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107967
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138449-07-7
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> INHIBITOR |
IC50
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OFF TARGET->WEAK INHIBITOR |
IC50
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OFF TARGET->WEAK INHIBITOR |
IC50
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
Evaluated in nine asthmatic
patients in a double-blind, placebo-controlled, crossover trial
and it was found that there was a significantly faster recovery from exercise-induced airway narrowing when pretreated with 2.5 mg FK888 by inhalation.
|
